Article
Chemistry, Multidisciplinary
Zhiheng Li, Danran Li, Huaming Xiang, Jian Huang, Yinuo Zheng, Cuiju Zhu, Xiuling Cui, Chao Pi, Hao Xu
Summary: In this study, a highly enantioselective propargylic substitution reaction of anthrones with propargylic esters using copper salts with chiral N, N, P-ligand was disclosed. This strategy shows broad substrate compatibility, mild reaction conditions, excellent yields with remarkable enantioselectivity, and enables the synthesis of diverse products.
CHINESE CHEMICAL LETTERS
(2022)
Article
Multidisciplinary Sciences
John M. Ovian, Petra Vojackova, Eric N. Jacobsen
Summary: Asymmetric transition-metal catalysis is a powerful strategy for producing enantiomerically enriched molecules. The traditional strategy for inducing enantioselectivity involves using chiral ligands to create a reactive metal site that promotes the formation of the major enantiomer and inhibits the formation of the minor enantiomer. However, this approach has limitations in certain scenarios. This study introduces a new approach that utilizes neutral hydrogen-bond donors to achieve enantioselectivity through ion pairing and non-covalent interactions. The results demonstrate high enantioselectivity in intramolecular ruthenium-catalyzed propargylic substitution reactions.
Article
Chemistry, Multidisciplinary
Han-Han Kong, Cuiju Zhu, Shuang Deng, Guang Xu, Ruinan Zhao, Chaochao Yao, Hua-Ming Xiang, Chunhui Zhao, Xiaotian Qi, Hao Xu
Summary: The copper-catalyzed enantioselective [4 + 1] annulation of yne-allylic esters with 1,3-dicarbonyl compounds was realized through an elegant remote stereocontrol strategy, leading to the formation of diverse spirocycles.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Nieves P. P. Ramirez, Jerome Waser
Summary: An asymmetric 3-component reaction catalyzed by a Cu-I-BOX catalyst was developed for the synthesis of chiral trifluoromethylated propargyl ethers and anilines. The reaction showed high enantioselectivity and yield with various nucleophiles and different electrophiles. The method also exhibited good diastereoselectivity with chiral substrates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jia-Hao Xie, Yi-Ming Hou, Zuolijun Feng, Shu-Li You
Summary: Here, we describe a synthesis method for cyclohexanones with multiple continuous stereocenters by combining copper-catalyzed asymmetric conjugate addition of dialkylzinc reagents to cyclic enones with iridium-catalyzed asymmetric allylic substitution reaction. The reaction yields good to excellent results in terms of yield, diastereoselectivity, and enantioselectivity. Unlike previous studies focusing on adjacent stereocenter construction (1,2-position), this reaction achieves stereodivergent construction of nonadjacent stereocenters (1,3-position) by utilizing two chiral catalysts with different enantiomers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Feng-Lin Hong, Chong-Yang Shi, Pan Hong, Tong-Yi Zhai, Xin-Qi Zhu, Xin Lu, Long-Wu Ye
Summary: In this study, a copper-catalyzed asymmetric cascade cyclization/[1,2]-Stevens-type rearrangement was reported to efficiently assemble a variety of valuable chiral chromeno[3,4-c]pyrroles bearing a quaternary carbon stereocenter with generally moderate to good yields and excellent enantioselectivities (up to 99% ee). Notably, this protocol represents the first example of catalytic asymmetric [1,2]-Stevens-type rearrangement based on alkynes and the first asymmetric formal carbene insertion into the Si-O bond.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Multidisciplinary Sciences
Qi Liu, Jian Zheng, Xue Zhang, Shengming Ma
Summary: In this study, visible light was successfully integrated into a transition metal-catalyzed coupling reaction to selectively form substituted allenenitriles. Mechanistic studies have shown that the reaction proceeds through a visible light-induced redox-neutral reductive quenching radical mechanism.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Wen Zhang, Ming-Hui Zhu, Hai-Xiang Zeng, Qi-Yang Li, Wen-Bo Liu
Summary: This study presents a highly enantioselective NiH-catalyzed hydrocyclization of alkynones, yielding an array of enantioenriched heterocyclic tertiary allylic alcohols. The choice of precatalysts significantly influences the selectivity of the products, with yields reaching up to 81%.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Huaxin Zhang, Yongge Xiong, Jiang Bai, Ruchun Yang, Xian-Rong Song, Qiang Xiao
Summary: We introduce a highly efficient and practical method for synthesizing gem-dibromo 1,3-oxazines through 6-endo-dig cyclization of propargylic amides, using N-bromosuccinimide (NBS) as an electrophilic source. This metal-free reaction can be carried out under mild conditions, showing good compatibility with various functional groups and providing excellent yields of the desired products. Mechanistic studies indicate that the reaction proceeds through a double electrophilic attack of NBS on the propargylic amide substrate.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Chemistry, Physical
Xue-Xin Zhang, Ying Zhang, Ling Liao, Yang Gao, Heng E. M. Su, Jin-Sheng Yu
Summary: This minireview summarizes the recent advancements in catalytic enantioselective isomerization and tandem reactions, discusses their advantages and limitations, and highlights the synthetic opportunities for further development.
Article
Nanoscience & Nanotechnology
Jian Zhao, Zhuo-Hao Jiao, Sheng-Li Hou, Yue Ma, Bin Zhao
Summary: Carboxylative cyclization of propargylic alcohols with CO2 is significant in synthetic chemistry, but often requires harsh conditions. A new stable nitro-functionalized metal-organic framework (MOF) was successfully fabricated through solvothermal reaction, which exhibited excellent stability in acid and basic solutions and served as an excellent platform for catalytic applications. The Ag-1 catalyst, prepared by incorporating Ag(I) ions into the MOF, displayed excellent catalytic performance in the chemical fixation of CO2 with alkynols under room temperature and atmospheric pressure, with a high turnover frequency (TOF) value.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Organic
Dandan Sun, Thayalan Rajeshkumar, Yifan Li, Jiaxin Xu, Runkai Chen, Zhaohua Wan, Zongchao Lv, Laurent Maron, Yi-Hung Chen
Summary: Transition-metal-catalyzed cross-coupling of propargylic electrophiles and Grignard reagents provides useful synthetic intermediates. However, few examples exist for the conversion of propargylic derivatives into propargyl compounds due to the challenging regioselectivity. We demonstrate a regioselective and stereospecific propargylation of Grignard reagents using LaCl3.2LiCl as a catalyst in the absence of a ligand.
Review
Chemistry, Organic
Pascal Matton, Steve Huvelle, Mansour Haddad, Phannarath Phansavath, Virginie Ratovelomanana-Vidal
Summary: Metal-catalyzed [2+2+2] cycloaddition is a powerful method for the rapid construction of functionalized 6-membered carbo- and heterocycles with high functional group tolerance. The reaction is usually regio- and chemoselective, but challenges remain for intermolecular reactions involving multiple alkynes.
SYNTHESIS-STUTTGART
(2021)
Article
Chemistry, Multidisciplinary
Ai-Ling Gu, Ya-Xin Zhang, Zhi-Lei Wu, Hui-Ya Cui, Tian-Ding Hu, Bin Zhao
Summary: The Cu2O@ZIF-8 catalyst was prepared and demonstrated its effectiveness in catalyzing the cyclization reactions of propargylic alcohols and propargylic amines with CO2. This is the first noble-metal-free catalyst to simultaneously catalyze both reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyu Tong, Felix Schneck, Gregory C. Fu
Summary: This study achieved the objective of using a nickel catalyst to perform enantioselective intermolecular alkylations of racemic Reformatsky reagents, resulting in α-alkylated carbonyl compounds. The importance of chiral catalysts in constructing carbonyl compounds with an α stereocenter was further demonstrated. Additionally, detailed mechanistic studies provided insights into key intermediates and elementary steps of the catalytic cycle.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Organic
Hiroaki Tsuji, Hisashi Yamamoto
Article
Chemistry, Organic
Kouichi Watanabe, Yusuke Miyazaki, Masataka Okubo, Biao Zhou, Hiroaki Tsuji, Motoi Kawatsura
Article
Chemistry, Organic
Hiroaki Tsuji, Keisuke Hashimoto, Motoi Kawatsura
Article
Chemistry, Organic
Yoshiyuki Takahashi, Hiroaki Tsuji, Motoi Kawatsura
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Takashi Hamaguchi, Yoshiyuki Takahashi, Hiroaki Tsuji, Motoi Kawatsura
Article
Chemistry, Organic
Yusuke Miyazaki, Biao Zhou, Hiroaki Tsuji, Motoi Kawatsura
Article
Chemistry, Multidisciplinary
Hiroaki Tsuji, Yuka Shimizu, Yusuke Miyazaki, Motoi Kawatsura
Summary: The study describes the development of nickel-catalyzed highly enantioselective propargylic amination, which resulted in the successful synthesis of chiral propargylic amines.
Article
Chemistry, Multidisciplinary
Hiroaki Tsuji, Takashi Hamaguchi, Motoi Kawatsura
Summary: This study describes the reaction conditions and products of nickel-catalyzed 1,2-hydroboration, achieving regioselective hydroboration of in situ generated 1,3-dienes to give secondary allylic boronates in high yields.
Article
Chemistry, Organic
Hiroaki Tsuji, Koki Suzuki, Motoi Kawatsura
Summary: In this study, the ruthenium-catalyzed benzylic alkylation of chiral benzyl esters with malonates was investigated, showing high enantioselectivity and retention of stereochemistry. The proposed mechanism for the reaction involves a double inversion process.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Organic
Hiroaki Tsuji, Yoshiyuki Takahashi, Motoi Kawatsura
Summary: This study reported the nickel-catalyzed hydroalkylation of 1,3-dienes with malonates using a homoallyl carbonate as the 1,3-diene and hydride source. Various homoallyl carbonates and malonate derivatives were well tolerated under a Ni/DPEphos catalyst system, providing high yields and regioselectivity for the 1,2-hydroalkylation products. The possible reaction mechanism for this nickel-catalyzed hydroalkylation was also proposed.
TETRAHEDRON LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Koki Suzuki, Hiroaki Tsuji, Motoi Kawatsura
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Organic
Kohei Oshimoto, Biao Zhou, Hiroaki Tsuji, Motoi Kawatsura
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Go Hamasaka, Hiroaki Tsuji, Masahiro Ehara, Yasuhiro Uozumi
Article
Chemistry, Organic
Kohei Oshimoto, Hiroaki Tsuji, Motoi Kawatsura
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)