Review
Pharmacology & Pharmacy
Peiying Shi, Shihui Xie, Jiali Yang, Yi Zhang, Shuo Han, Songkun Su, Hong Yao
Summary: This study reviewed the recent progress in the pharmacological effects and mechanisms of bee venom (BV) and its main components against various diseases. It identified the target proteins and signaling pathways involved, and bioinformatically predicted the potential effects and mechanisms on diseases. The review provides new insights into the therapeutic effects of BV and its main components.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anna Kurek-Gorecka, Katarzyna Komosinska-Vassev, Anna Rzepecka-Stojko, Pawel Olczyk
Summary: Bee venom, also known as apitoxin, is widely used in the treatment of inflammatory diseases and has been found to accelerate wound healing by regulating growth factors, cell activities and promoting cell proliferation and migration in the skin.
Review
Pharmacology & Pharmacy
Amjad Ullah, Fahad Mohammed Aldakheel, Syed Ishtiaq Anjum, Ghulam Raza, Saeed Ahmad Khan, Ivana Tlak Gajger
Summary: Honey bee venom is a valuable product with a wide range of biological effects, and its use in apitherapy is increasing rapidly. It is composed of many biologically active substances and has various pharmacological properties, including anticancer, antimicrobial, anti-inflammatory, and anti-arthritis effects. Honey bee venom has been used for centuries in medicine and is currently being researched for more effective use in modern medicine.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Abdelwahab Khalil, Basem H. Elesawy, Tarek M. Ali, Osama M. Ahmed
Summary: Insects of the order Hymenoptera, such as honeybees, have venom containing various bioactive compounds that have potential therapeutic applications. Research suggests that bee venom and its components exhibit multiple biological activities, including anti-microbial, anti-inflammatory, and anti-cancer properties. There is ongoing exploration of utilizing bee venom as a drug delivery vehicle and discussing its molecular mechanisms for potential medical benefits.
Review
Food Science & Technology
Aida A. Abd El-Wahed, Shaden A. M. Khalifa, Mohamed H. Elashal, Syed G. Musharraf, Aamer Saeed, Alfi Khatib, Haroon Elrasheid Tahir, Xiaobo Zou, Yahya Al Naggar, Arshad Mehmood, Kai Wang, Hesham R. El-Seedi
Summary: Bee venom is widely used in skin care products to treat various skin diseases, but safety concerns exist due to potential allergic reactions. Studies have shown that adverse reactions to bee venom can lead to excessive immune responses, including anaphylaxis, which typically resolve over time.
Review
Food Science & Technology
Jaehee Yoo, Gihyun Lee
Summary: This article summarizes the use of bee venom in various ways and the associated adverse events. It highlights the need for strict reporting standards for adverse events related to bee venom. The study suggests that large-scale clinical RCTs are needed to evaluate the results.
Article
Pharmacology & Pharmacy
Huang Kuang, Xin Huang, Zhifeng Zhou, Xuexin Cheng, Gaosi Xu
Summary: LCZ696, a novel angiotensin receptor-neprilysin inhibitor, may be beneficial in the treatment of CKD patients. Current research is primarily focused on patients with heart failure, but more studies in CKD patients alone are needed in the future.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Yue Mou, XueZhen Wang, Tong Wang, Yuan Wang, HuaXin Wang, HaiJun Zhao, Qian Chen, Lei Xia, YaNan Zhang
Summary: Wuling powder is a classic prescription for the treatment of ascites, with well-defined pharmacological effects and chemical constituents. Through clinical research and network pharmacology analysis, key targets and pathways of WLP in treating ascites can be identified, providing theoretical support for its clinical application.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Food Science & Technology
Soo-Hyun Sung, Ji-Eun Han, Hee-Jung Lee, Minjung Park, Ji-Yeon Lee, Soobin Jang, Jang-Kyung Park, Gihyun Lee
Summary: This study identified the characteristics of bee venom acupuncture for the treatment of lower back pain described in Korean literature. It analyzed clinical studies on bee venom acupuncture interventions for back pain and found positive effects on pain relief. The study provides valuable clinical cases for the future development and standardization of bee venom acupuncture treatment for back pain.
Review
Geriatrics & Gerontology
Min Hao, Yue Chu, Jingxuan Lei, Zhouhui Yao, Pingping Wang, Ziyan Chen, Kuilong Wang, Xianan Sang, Xin Han, Lu Wang, Gang Cao
Summary: Curcumin, a polyphenol extracted from turmeric, has shown extensive pharmacological activities. However, its clinical application is limited due to low bioavailability. Dosage form transformations can improve the druggability of curcumin and enhance its clinical prospects.
Article
Integrative & Complementary Medicine
Sol-Ji Kim, Ji-Hee Yeo, Seo-Yeon Yoon, Dae-Hyun Roh
Summary: The study revealed that repetitive DBV treatment at the GV16 acupoint can alleviate facial and hindpaw hypersensitivities induced by NTG and decrease c-Fos expression in the TNC through activation of alpha-2 adrenoceptors, but not opioid receptors.
INTEGRATIVE MEDICINE RESEARCH
(2023)
Review
Medicine, Research & Experimental
Qiang Zhang, Lijuan Zhang, Yu Liu, Xu Tian, Xiuyang Li, Bingbing Han, Yanan Zhang, Zhichun Wu, Huayun Yu, Haijun Zhao, Shijun Wang, Ke Ma, Yuan Wang
Summary: This paper systematically introduces clinical and experimental studies of Tongqiao Huoxue Decoction (THD) in the treatment of ischaemic stroke (IS), summarising its clinical application, pharmacological mechanisms, and active components. It explores the key pathways in the treatment of IS through network pharmacology analyses and speculates on its underlying mechanisms, which is significant for the secondary development of this classic prescription and research and development of new drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Soon Uk Chae, Seong Jun Jo, Chae Bin Lee, Sangyoung Lee, Ji-Hyun Park, Jin-Su Jung, Eui-Suk Park, Hyunsu Bae, Soo Kyung Bae
Summary: Bee venom and its component phospholipase A2 have potential in treating Alzheimer's disease by suppressing neuroinflammation. In this study, the pharmacokinetic profiles of phospholipase A2 in a new composition of bee venom were characterized in rats. The results showed a dose-dependent increase in the pharmacokinetic parameters of phospholipase A2, suggesting its potential clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Na-Yoen Kwon, Soo-Hyun Sung, Hyun-Kyung Sung, Jang-Kyung Park
Summary: Bee venom and its components have been found to have anticancer effects on breast cancer cells by reducing cell numbers and improving survival rates. The various mechanisms of action suggest the potential for reducing side effects and the future prevention and treatment of breast cancer.
Review
Food Science & Technology
Jasmin Katrin Badawi
Summary: Prostate cancer is one of the most common cancers in men, with challenges in disease progression and resistance of cancer cells to available therapeutic agents. Further therapeutic agents are needed, and bee venom components have shown promising anticancer effects, particularly melittin.
