Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 33, Issue -, Pages 32-38Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2016.05.015
Keywords
-
Categories
Funding
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
Ask authors/readers for more resources
The monoclonal antibody (mAb) has proven to be a good platform for designing specific molecular imaging probes due to its superior binding specificity. Several optical imaging probes have been developed for surgical navigation in patients and are in early phase clinical trials. However, an inherent limitation of using the mAb is its pharmacokinetics which result in a prolonged circulating half-life and slow clearance from the body. This results in undesirable target to background ratios during imaging. In this review, we first describe the mAb as a platform material for optical probe design and then discuss optimizing the design of monoclonal antibody-based optical molecular imaging probes by focusing on chemistry, biology and pharmacology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available