Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 32, Issue -, Pages 60-66Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2016.04.014
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Multiple sclerosis is a devastating chronic autoimmune disease affecting women and men of all ages. Inflammation of the central nervous system causes demyelination and ultimately neuropsychological dysfunction. Myriocin, a natural product with strong immunosuppressant activity was interrogated leading to a new class of immunomodulator with a unique mode of action. In this review, we will summarize these findings, the mechanism hypothesis and discuss the data's ultimately leading to the approval of Gilenya (TM) as the first oral treatment for multiple sclerosis.
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