Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease

Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution

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Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease

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Clinical benefit of dolutegravir in HIV-1 management related to the high genetic barrier to drug resistance

(2017) Bluma G. Brenner et al.   VIRUS RESEARCH

Local fitness landscape of the green fluorescent protein

(2016) Karen S. Sarkisyan et al.   NATURE

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(2016) Tyler N. Starr et al.   PROTEIN SCIENCE

Adaptation in protein fitness landscapes is facilitated by indirect paths

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Hepatitis C virus drug resistance-associated substitutions: State of the art summary

(2015) Erik Lontok et al.   HEPATOLOGY

HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry

(2015) Jing Zhou et al.   JOURNAL OF VIROLOGY

Deep Sequencing of Protease Inhibitor Resistant HIV Patient Isolates Reveals Patterns of Correlated Mutations in Gag and Protease

(2015) William F. Flynn et al.   PLoS Computational Biology

Persistence of Transmitted HIV-1 Drug Resistance Mutations Associated with Fitness Costs and Viral Genetic Backgrounds

(2015) Wan-Lin Yang et al.   PLoS Pathogens

A Comprehensive Biophysical Description of Pairwise Epistasis throughout an Entire Protein Domain

(2014) C. Anders Olson et al.   CURRENT BIOLOGY

A Systematic Survey of an Intragenic Epistatic Landscape

(2014) Claudia Bank et al.   MOLECULAR BIOLOGY AND EVOLUTION

Strong Epistatic Interactions within a Single Protein

(2014) Mariona Parera et al.   MOLECULAR BIOLOGY AND EVOLUTION

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

High-throughput profiling of point mutations across the HIV-1 genome

(2014) Laith Q Al-Mawsawi et al.   Retrovirology

A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity

(2014) Hangfei Qi et al.   PLoS Pathogens

Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design

(2013) Andrew L. Ferguson et al.   IMMUNITY

Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure

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The distinct contributions of fitness and genetic barrier to the development of antiviral drug resistance

(2012) Matthias Götte   Current Opinion in Virology

Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis

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Accessory Mutations Maintain Stability in Drug-Resistant HIV-1 Protease

(2011) Max W. Chang et al.   JOURNAL OF MOLECULAR BIOLOGY

A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase

(2011) Trevor Hinkley et al.   NATURE GENETICS

Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

(2011) A. I. Khan et al.   SCIENCE

Pervasive Sign Epistasis between Conjugative Plasmids and Drug-Resistance Chromosomal Mutations

(2011) Rui F. Silva et al.   PLoS Genetics

HIV-1 Protease Mutations and Protease Inhibitor Cross-Resistance

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Compensation of Fitness Costs and Reversibility of Antibiotic Resistance Mutations

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Antibiotic resistance and its cost: is it possible to reverse resistance?

(2010) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

Epistasis among Deleterious Mutations in the HIV-1 Protease

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Positive Epistasis Drives the Acquisition of Multidrug Resistance

(2009) Sandra Trindade et al.   PLoS Genetics

Resistance Profile of Darunavir: Combined 24-Week Results from the POWER Trials

(2008) Sandra de Meyer et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Second generation HIV protease inhibitors against resistant virus

(2008) Zhijian Lu   Expert Opinion on Drug Discovery

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

(2008) Paul A. Goepfert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Minority HIV-1 Drug Resistance Mutations Are Present in Antiretroviral Treatment–Naïve Populations and Associate with Reduced Treatment Efficacy

(2008) Jeffrey A Johnson et al.   PLOS MEDICINE

Drug resistance in HIV-1 protease: Flexibility-assisted mechanism of compensatory mutations

(2002) Stefano Piana et al.   PROTEIN SCIENCE