Article
Environmental Sciences
Joseph M. Braun, George D. Papandonatos, Nan Li, Clara G. Sears, Jessie P. Buckley, Kim M. Cecil, Aimin Chen, Charles B. Eaton, Heidi J. Kalkwarf, Karl T. Kelsey, Bruce P. Lanphear, Kimberly Yolton
Summary: In this cohort, physical activity during adolescence modified the association between prenatal serum PFOA concentrations and cardiometabolic risk in children, suggesting that lifestyle interventions may alleviate the adverse effects of PFOA exposure. However, diet did not modify any associations.
ENVIRONMENTAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Tim Lobstein, Kelly D. Brownell
Summary: Emerging evidence suggests that industrially produced endocrine-disrupting chemicals may contribute to obesity, and should be considered in obesity prevention policies. However, current policy documents have limited content on the control and avoidance of exposure to EDCs.
Review
Oncology
Priscilla Roberta Silva Rocha, Valdiane Dutra Oliveira, Christiane Inocencio Vasques, Paula Elaine Diniz dos Reis, Angelica Amorim Amato
Summary: The study found an association between human exposure to endocrine disruptors (EDs) and increased risk of breast cancer, but further research is needed to determine if this association is causal.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Environmental Sciences
Ravi Naidu, Bhabananda Biswas, Ian R. Willett, Julian Cribb, Brajesh Kumar Singh, C. Paul Nathanail, Frederic Coulon, Kirk T. Semple, Kevin C. Jones, Adam Barclay, Robert John Aitken
Summary: Anthropogenic chemical pollution has the potential to threaten humanity's environmental health significantly; however, global understanding of this issue remains fragmented. There are serious gaps in our understanding of the scale of the threat and the risks posed by the dispersal, mixture, and recombination of chemicals in the wider environment. Despite the existence of pollution control measures, they are often not being implemented at the necessary rate to prevent chronic and acute effects on human health.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Engineering, Environmental
Md Saidur Rahman, Elikanah Olusayo Adegoke, Myung-Geol Pang
Summary: Bisphenol A (BPA) is a common environmental toxin, despite documented toxicity, it is still widely used in consumer products. Factors influencing human exposure to BPA include material properties, lack of health education, fear of BPA substitutes, inappropriate production, and regulatory guidance.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Andreas Vilhelmsson, Lars Rylander, Anna Joud, Christian H. Lindh, Kristina Mattsson, Zeyan Liew, Pengfei Guo, Beate Ritz, Karin Kallen, Jesse D. Thacher
Summary: This study investigated the association between prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and cerebral palsy (CP) in Swedish children. The results showed a positive association between PFAS exposure and CP in preterm infants, but no consistent evidence of associations in the overall group. Further research is needed to explore this issue.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Multidisciplinary Sciences
Adhena Ayaliew Werkneh, Shifare Berhe Gebru, Gebru Hailu Redae, Arega Gashaw Tsige
Summary: Endocrine-disrupting compounds (EDCs) are emerging contaminants that disrupt endocrine hormones and system functionality even at low concentrations. They are found in various components of the environment and lack standard regulations. Effective removal technologies are essential to address this issue. EDCs cause various public health diseases and have significant implications for future research.
Article
Environmental Sciences
Qian Wu, Gang Li, Chen-Yang Zhao, Xiao-Lin Na, Yun-Bo Zhang
Summary: According to a systematic review and meta-analysis, phthalate exposure is associated with an increased risk of obesity in both children and adults. The positive correlation is particularly significant in women and in Europe and the United States. These findings suggest a substantial association between phthalate exposure and obesity.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Cell Biology
Huan Yi, Huamin Wu, Wenbin Zhu, Qi Lin, Xiaoyan Zhao, Rong Lin, Yan Luo, Lixiang Wu, Danmei Lin
Summary: The study aimed to explore the correlations between phthalates, common environmental endocrine disruptors, and ovarian dysfunction in endometriosis. The levels of phthalates in urine samples were significantly higher in women with endometriosis. In rat models, exposure to DEHP resulted in decreased ovarian and uterine mass index, irregular estrous cycle, and negatively correlated serum AMH levels. These findings suggest that phthalate exposure, especially DEHP, is associated with endometriosis and affects ovarian function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Environmental Sciences
Hong Zhang, Yujie Ben, Yonghe Han, Yong Zhang, Yu Li, Xinwang Chen
Summary: The meta-analysis showed a positive association between phthalate exposure and risk of DM, especially for MMP, MnBP, MiBP, MCPP, and DEHP metabolites. However, caution should be taken in interpreting the results due to the heterogeneous design of the enrolled studies.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
T. S. Barton-Maclaren, M. Wade, N. Basu, S. Bayen, J. Grundy, V Marlatt, R. Moore, L. Parent, J. Parrott, P. Grigorova, J. Pinsonnault-Cooper, V. S. Langlois
Summary: Globally, regulatory authorities are addressing the challenges of assessing the hazards and risks associated with exposure to endocrine disrupting chemicals. A revolution in toxicology focusing on New Approach Methodologies (NAMs) is allowing for more efficient and mechanistically driven assessment of potential risks. Emerging approaches prioritize molecular interactions and biological systems over traditional animal toxicity data, with the goal of minimizing risks from EDC exposure.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Martina Capriotti, Paolo Cocci, Luca Bracchetti, Erika Cottone, Rosaria Scandiffio, Giovanni Caprioli, Gianni Sagratini, Gilberto Mosconi, Patrizia Bovolin, Francesco Alessandro Palermo
Summary: This study presented environmental baseline data on floating microplastics in Italian coastal waters of the Central Adriatic Sea, revealing the presence of various organic pollutants on the surface of collected microplastics. Furthermore, the study indicated potential metabolic effects of microplastics on adipocytes, resulting in both adipogenesis and lipid uptake/storage.
Article
Environmental Sciences
Anna S. Young, Nicholas Herkert, Heather M. Stapleton, Brent A. Coull, Russ Hauser, Thomas Zoeller, Peter A. Behnisch, Emiel Felzel, Abraham Brouwer, Joseph G. Allen
Summary: Humans are exposed to complex mixtures of hormone-disrupting chemicals, and traditional research methods do not evaluate enough chemicals at once. This study used silicone wristbands to investigate exposures to chemical mixtures in office workers from different countries. The results revealed associations between chemical concentrations and hormonal activities, and identified several important chemicals contributing to the overall mixture effects. The study emphasized the role of personal care products and building microenvironments in hormone-disrupting exposures.
Article
Nutrition & Dietetics
Krystyna Makowska, Ewa Lepiarczyk, Slawomir Gonkowski
Summary: Bisphenol A (BPA), commonly used as a plasticizer, has a strong negative effect on living organisms and is being replaced by bisphenol S (BPS) in plastic production. This study compares the impact of BPA and BPS on enteric neurons for the first time using double immunofluorescence technique. Both BPA and BPS affect the number of enteric neurons containing various neuronal factors, with BPS showing a stronger impact on certain neuronal populations. The results indicate that long-term exposure to BPS, even in low doses, is not neutral for enteric neurons and may be more potent than BPA for certain neuronal populations.
Article
Environmental Sciences
G. O. Olutona, I. A. Fakunle, R. A. Adegbola
Summary: The use of agricultural pesticides and fertilizers has increased the concentration of organochlorine pesticide residue and heavy metals in vegetables sold in market. The presence of these residues may lead to neurological, reproductive, and immune system disorders in humans through food consumption.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Review
Food Science & Technology
Kelsey Robson, Moira Dean, Simon Haughey, Christopher Elliott
Summary: With ambiguous definitions and lack of specific guidance on food fraud in the food industry, there are challenges in understanding and preventing it effectively. The lack of clarity has resulted in varying definitions and a gap in knowledge regarding prevention and mitigation strategies. Further research and collaboration are needed to establish common practices and address the issue of food fraud comprehensively.
Article
Water Resources
Mazia Amber, Yuling Xie, Hanne Friis Berntsen, Karin Elizabeth Zimmer, Erik Ropstad, Steven Verhaegen, Lisa Connolly
Summary: Exposure to a total mixture of 29 persistent organic pollutants altered mitochondrial metabolism and induced cell death via an alternative mechanism to valinomycin. Specific combinations of individual chemical classes, but not the total mixture, affected cell number.
EXPOSURE AND HEALTH
(2021)
Article
Water Resources
Y. Xie, H. F. Berntsen, K. E. Zimmer, E. Ropstad, S. Verhaegen, L. Connolly
Summary: This study assessed the adipogenic effects of a POPs mixture modelled on real-life human exposure levels, finding that such exposures may alter adipose tissue development and function, potentially playing a role in the globally increasing escalation of metabolic disorders.
EXPOSURE AND HEALTH
(2022)
Article
Behavioral Sciences
Moira Dean, Chloe O'Kane, Johann Issartel, Amanda McCloat, Elaine Mooney, Claire McKernan, Stephanie Brooks, Niamh O'Kane, William Crowe, Blain Murphy, Fiona Lavelle
Summary: The theory-driven and co-created children's cooking intervention 'Cook Like A Boss' was effective in improving children's perceived cooking competence, with significant positive results and high fidelity in process evaluations. This multidisciplinary approach, guided by theory, could serve as a template for future children's cooking interventions.
Review
Pharmacology & Pharmacy
Jerrold J. Heindel, Sarah Howard, Keren Agay-Shay, Juan P. Arrebola, Karine Audouze, Patrick J. Babin, Robert Barouki, Amita Bansal, Etienne Blanc, Matthew C. Cave, Saurabh Chatterjee, Nicolas Chevalier, Mahua Choudhury, David Collier, Lisa Connolly, Xavier Coumoul, Gabriella Garruti, Michael Gilbertson, Lori A. Hoepner, Alison C. Holloway, George Howell, Christopher D. Kassotis, Mathew K. Kay, Min Ji Kim, Dominique Lagadic-Gossmann, Sophie Langouet, Antoine Legrand, Zhuorui Li, Helene Le Mentec, Lars Lind, P. Monica Lind, Robert H. Lustig, Corinne Martin-Chouly, Vesna Munic Kos, Normand Podechard, Troy A. Roepke, RobertM. Sargis, Anne Starling, Craig R. Tomlinson, Charbel Touma, Jan Vondracek, Frederick vom Saal, Bruce Blumberg
Summary: Obesity is a multifactorial disease caused by genetic and environmental factors. Overeating and lack of exercise are common causes, but environmental substances known as obesogens can also disrupt the balance of energy intake and expenditure, increasing the risk of obesity. Obesogens primarily affect the development and function of adipose tissue, liver, pancreas, gastrointestinal tract, and brain, altering the control of metabolism. The most sensitive period for obesogen exposure is in utero and early childhood, which may lead to changes in gene expression that can be transmitted to future generations.
BIOCHEMICAL PHARMACOLOGY
(2022)
Correction
Pharmacology & Pharmacy
Jerrold J. Heindel, Sarah Howard, Keren Agay-Shay, Juan P. Arrebola, Karine Audouze, Patrick J. Babin, Robert Barouki, Amita Bansal, Etienne Blanc, Matthew C. Cave, Saurabh Chatterjee, Nicolas Chevalier, Mahua Choudhury, David Collier, Lisa Connolly, Xavier Coumoul, Gabriella Garruti, Michael Gilbertson, Lori A. Hoepner, Alison C. Holloway, George Howell, Christopher D. Kassotis, Mathew K. Kay, Min Ji Kim, Dominique Lagadic-Gossmann, Sophie Langouet, Antoine Legrand, Zhuorui Li, Helene Le Mentec, Lars Lind, P. Monica Lind, Robert H. Lustig, Corinne Martin-Chouly, Vesna Munic Kos, Normand Podechard, Troy A. Roepke, Robert M. Sargis, Anne Starling, Craig R. Tomlinson, Charbel Touma, Jan Vondracek, Frederick vom Saal, Bruce Blumberg
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Food Science & Technology
Sophie Lawrence, Christopher Elliott, Wim Huisman, Moira Dean, Saskia van Ruth
Summary: Seafood is a commodity that is highly susceptible to food fraud due to its complex and opaque supply chains. This study analyzes reported seafood fraud incidents and identifies illegal veterinary residues as a significant concern, with most reports originating from farmed seafood in Vietnam, China, and India. The analysis also highlights the frequency of fraudulent or insufficient documentation in internationally traded goods, indicating deceptive practices further down the supply chain.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Behavioral Sciences
Tony Benson, Tamara Bucher, Rachel Oughton, Amanda McCloat, Elaine Mooney, Sarah Farrell, Moira Dean
Summary: This manuscript presents two studies that examine the impact of nutrition and health claims (NHCs) on food selection and nutritional composition. The results indicate that the presence of NHCs can significantly reduce the amount of energy, fat, saturated fat, sugar, carbohydrates, and sodium in meals, while increasing the amount of protein. NHCs also lead to an increase in the quantity of food served as snacks. However, there is no evidence that NHCs at breakfast affect the nutritional composition of subsequent lunch servings. These findings have important implications for government policy, food reformulation, and the use of nutrient profiling regulations for products carrying claims.
Article
Environmental Sciences
Anika Beyer, Paula Schorgg, Nena Karavasiloglou, Sneha Sarwar, Sabine Rohrmann, Till Barnighausen, Aedin Cassidy, Lisa Connolly, Tilman Kuhn
Summary: Phthalate exposure is associated with increased mortality, emphasizing the need for monitoring its impact on health outcomes.
ENVIRONMENTAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Sinead Watson, Hannah O'Hara, Dharsshini Reveendran, Christopher Cardwell, Kevin G. Murphy, Tony Benson, Moira Dean, Jayne V. Woodside
Summary: Health claims on food labels may influence satiation as measured by self-reported fullness, but have limited effects on appetite-regulating gut hormone levels.
Article
Food Science & Technology
Y. Xie, H. F. Berntsen, K. E. Zimmer, E. Ropstad, S. Verhaegen, L. Connolly
Summary: This study found that human exposure to persistent organic pollutants (POPs) may contribute to obesogenic effects. The addition of luteolin, a flavone compound, to a human relevant mixture of POPs in the laboratory was able to inhibit adipocyte formation and intracellular lipid accumulation.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Water Resources
Jamie English, Lisa Connolly, Linda D. Stewart
Summary: The intestinal epithelium is the first line of defence against pathogens in the gastrointestinal tract and its structure and function are important for maintaining a healthy gut environment. Tight junction complexes between intestinal epithelial cells play a key role in maintaining the integrity of the gut barrier. Genetic and environmental factors can impact the effectiveness of these tight junction complexes and increase the permeability of the intestine, which has been associated with autoimmune diseases.
EXPOSURE AND HEALTH
(2023)
Article
Business
Mara Martini, Barbara Loera, Blain Murphy, Moira Dean, Egidio Dansero, Angela Fedi
Summary: This paper used a sequential mixed-method design to explore consumer acceptability of a biomarker solution for organic vegetables aimed at enhancing consumer trust. Five focus groups were conducted to examine consumer reactions to this technology and possible nomenclatures. A survey in four European countries then analyzed consumer attitudes and acceptability of biomarker technology. The results highlighted the complex relationship between the perception of biomarkers and consumer trust.
JOURNAL OF INTERNATIONAL CONSUMER MARKETING
(2023)
Article
Toxicology
Emma Harper, Eoin Cunningham, Lisa Connolly
Summary: This study assesses the migration of endocrine disrupting leachates from bio-based polymers used in food packaging development. The results show that most of the tested bio-based polymers and additives did not significantly reduce metabolic activity or hormonal activity. However, some combinations did exhibit estrogenic and anti-androgenic activity, although at much lower levels than traditional petroleum-based plastics. Manipulating additives and formulations alongside toxicological testing can further improve the safety of bio-based packaging alternatives.
FRONTIERS IN TOXICOLOGY
(2022)
Review
Toxicology
Elysia Jewett, Gareth Arnott, Lisa Connolly, Nandini Vasudevan, Eva Kevei
Summary: Biologically active environmental pollutants, such as microplastic and nanoplastic particles, have significant impact on ecosystems, wildlife, and human health. These plastic particles can cause oxidative stress, inflammation, and cellular damage, resulting in reproductive and health issues in animals and humans. However, the full extent of their impact is not yet fully understood, though they carry additional risks through the contaminants and toxic chemicals they transport.
FRONTIERS IN TOXICOLOGY
(2022)
