Article
Biochemistry & Molecular Biology
Saki Sakakura, Emi Inagaki, Yuichiro Ochiai, Masatoshi Yamamoto, Naofumi Takai, Taeko Nagata, Kazunari Higa, Yasunori Sato, Hiroshi Toshida, Dogru Murat, Masatoshi Hirayama, Yoko Ogawa, Kazuno Negishi, Shigeto Shimmura
Summary: The tear film stability of a rabbit dry eye model induced by dacryoadenectomy was assessed in this study. The results showed that this model partially captured the phenotypes of human short TBUT-type dry eye, making it a potentially useful animal model for investigating potential drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Tai-Yuan Su, Shu-Wen Chang
Summary: By constructing normalized ocular surface temperature (NOST) models for different tear film characteristics, it is possible to differentiate tear film types and potentially use them for dry-eye screening. The study found that in dry-eye screening, the NOST order was normal > short-BUT > short BUT with SPK.
Review
Mathematical & Computational Biology
J. Richard Braun, A. Rayanne Luke, A. Tobin Driscoll, G. Carolyn Begley
Summary: This paper reviews mathematical models and theories for the human tear film on the ocular surface, focusing on localized flows where the tear film may fail. The models attempt to identify the important physical processes and parameters governing the tear film in health and disease.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Ophthalmology
Paramdeep Bilkhu, James Wolffsohn, Christine Purslow
Summary: The study found that concentration task and treatment had different effects on tear film evaporation rate, tear meniscus height, symptomology, etc. Tear film lipid layer thickness, non-invasive tear film break-up time and tear meniscus height may be key clinical metrics that drive ocular comfort.
CONTACT LENS & ANTERIOR EYE
(2021)
Review
Ophthalmology
Shizuka Koh, Srinivas Rao, Sanjeev Srinivas, Louis Tong, Alvin Young
Summary: With the increasing prevalence of dry eye disease, there is a growing focus on diagnostic methods. Numerous technologies have been developed to measure tear function and ocular surface health, but finding a cost-effective and efficient method remains challenging. In the Indian context, a quick and easy clinical approach for accurate diagnosis is needed as most patients consult general ophthalmologists.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Zhengyu Gu, Qinyi Lu, Ao Zhang, Zong Wen Shuai, Rongfeng Liao
Summary: The study showed that Systemic Lupus Erythematosus (SLE) patients without secondary Sjogren's syndrome are at a higher risk for dry eye disease (DED) compared to healthy populations, with poorer ocular surface characteristics and tear film quality. A combination of SLE disease activity index (SLEDAI), age, and non-invasive tear film breakup time (NIKBUT) demonstrated high efficiency in diagnosing DED in SLE patients, suggesting practical clinical applications.
FRONTIERS IN MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Joon Young Hyon, Sang Beom Han
Summary: Dry eye disease is a global public health problem that impairs quality of life and poses economic burden. Inflammation plays a key role in the worsening of the disease, and besides anti-inflammatory medications, vitamin supplementation may also be effective.
APPLIED SCIENCES-BASEL
(2022)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation-and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The study found that IL-10 and SP levels in tears were increased in patients with a history of corneal refractive surgery. IL-9 levels were associated with chronic ocular pain. These findings suggest that tear cytokines and neuromodulators could serve as biomarkers for chronic ocular pain, leading to improved therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation- and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The results showed that IL-9 tear levels were increased in patients with chronic ocular pain, IL-10, SP, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with previous surgery, and IL-8/CXCL8, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with DE-related inflammation. Higher NGF levels were related to chronic ocular pain and DE in patients with previous surgery. These findings are important for understanding biomarkers of chronic ocular pain and making better therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Medicine, General & Internal
Maria Carmen Sanchez-Gonzalez, Raul Capote-Puente, Marta-C Garcia-Romera, Concepcion De-Hita-Cantalejo, Maria-Jose Bautista-Llamas, Carmen Silva-Viguera, Jose-Maria Sanchez-Gonzalez
Summary: This study describes the role of OSA as a new non-invasive diagnostic device for dry eye disease. OSA provides accurate and non-invasive parameters to interpret distinct functions of the tear film. A complete examination protocol for OSA and OSA Plus devices is presented. These devices represent a renewal in dry eye disease diagnosis and have the potential to replace invasive techniques.
FRONTIERS IN MEDICINE
(2022)
Review
Biology
Norihiko Yokoi, Petar Eftimov, Georgi As. Georgiev
Summary: Soft contact lenses cause disturbances in the connection between the pre-lens tear film and the ocular surface, resulting in dry eye and discomfort. Factors such as decreased tear meniscus radius, attenuated spread of tear film lipid layer, limited wettability of contact lens surface, and increased friction with eyelid wiper contribute to these issues. This review examines the contributions of these factors to tear film breakup patterns and contact lens discomfort from a clinical and basic science perspective.
Article
Medicine, General & Internal
Dominika Szkodny, Adam Wylegala, Edyta Chlasta-Twardzik, Edward Wylegala
Summary: This study aimed to evaluate the ocular surface parameters of post-COVID-19 patients when compared to healthy controls. The results showed no significant differences between the post-COVID group and control group in the objective measurements of ocular surface conditions, when performed after the acute phase of COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jose-Maria Sanchez-Gonzalez, Carmen Silva-Viguera, Maria Carmen Sanchez-Gonzalez, Raul Capote-Puente, Concepcion De-Hita-Cantalejo, Antonio Ballesteros-Sanchez, Lydia Ballesteros-Duran, Marta-C. Garcia-Romera, Estanislao Gutierrez-Sanchez
Summary: This study evaluated the effectiveness of hyaluronic acid and trehalose eyedrops in managing dry eye disease symptoms. The results showed that using hyaluronic acid and trehalose eyedrops can significantly improve tear stability and reduce dry eye symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.
Review
Ophthalmology
Barbara Burgos-Blasco, Pedro Arriola-Villalobos, Jose Ignacio Fernandez-Vigo, Carlos Oribio-Quinto, Mayte Arino-Gutierrez, David Diaz-Valle, Jose Manuel Benitez-del-Castillo
Summary: During the COVID-19 period, the use of face masks has significantly increased. Studies have shown that the rise in ocular discomfort symptoms, known as mask-associated dry eye (MADE), is mainly due to the effect of face masks. Wearing a face mask can create an unnatural upward airflow towards the eyes during expiration, leading to dry eye disease. Other factors such as increased temperature, humidity, carbon dioxide levels, stress, increased use of video display terminals, and changes in the ocular microbiota may also contribute to ocular discomfort. It is important to understand the effects and consequences of mask use on the ocular surface, especially considering the potential prolonged use of masks in the future.
Article
Ophthalmology
Paramdeep Bilkhu, Zimar Sivardeen, Connie Chen, Jennifer P. Craig, Kylie Mann, Michael T. M. Wang, Saleel Jivraj, Karim Mohamed-Noriega, David E. Charles-Cantu, James S. Wolffsohn
Summary: The purpose of this study was to explore how patients in different countries manage their dry eye symptoms. The results showed that there were differences in the duration and severity of symptoms between countries, but no significant difference in the impact of symptoms on quality of life. However, few people consulted healthcare professionals and only about half of the respondents tried treatment options.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Cardiac & Cardiovascular Systems
Yi-Wen (Becky) Liao, Tom Kai Ming Wang, Michael Tzu Min Wang, Tharumenthiran Ramanathan, Miriam Wheeler
Summary: This study compared mitral valve repair and replacement in patients with rheumatic heart disease and found that mitral valve repair is associated with a reduction in operative and long-term mortality and bleeding, but it does entail a higher rate of reoperation during follow-up.
HEART LUNG AND CIRCULATION
(2022)
Article
Ophthalmology
Jinsong Xue, Haiou Wang, Min Wang, Qingyan Zeng, Vishal Jhanji, Andy D. Kim, Michael T. M. Wang, Yingnan Xu, Xiuming Jin, Wei Chen
Summary: In patients with advanced keratoconus, DALK leads to larger reductions in Kmax and better improvement in visual acuity compared to CXL.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Clinical Neurology
Michael T. M. Wang, Zak J. Prime, William Xu, James McKelvie, Taras Papchenko, Tanyatuth Padungkiatsagul, Heather E. Moss, Helen V. Danesh-Meyer
Summary: This study assessed the diagnostic utility of neuroradiologic signs associated with idiopathic intracranial hypertension in patients presenting with papilloedema. The results showed that the sensitivity of these signs was modest, suggesting the routine use of lumbar puncture assessment following neuroimaging to secure the diagnosis.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Michael T. M. Wang, M. Tariq Bhatti, Helen Danesh-Meyer
Summary: Idiopathic intracranial hypertension (IIH) is a condition characterized by increased intracranial pressure, primarily affecting obese women of reproductive age. The pathophysiology involves disruptions in cerebrospinal fluid dynamics and venous sinus pressure. Current treatment goals aim to relieve symptoms and prevent permanent vision loss. Further research is needed to determine the optimal treatment regimen.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Ophthalmology
Alexandra Z. Crawford, Simone E. N. Freundlich, Joevy Lim, Charles N. J. McGhee
Summary: This study confirms that endocapsular insertion of an artificial iris is typically associated with good functional and cosmetic results and a relatively low risk of significant complications.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Review
Clinical Neurology
William Shew, Michael T. M. Wang, Helen V. Danesh-Meyer
Summary: A systematic review and meta-analysis showed that the risk of NAION after cataract surgery is four times higher within the first year and mostly occurs within 6 months. However, the absolute risk is low, with 1 in 1,000-3,100 surgeries, and does not require extra mention during consent.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jennifer P. Craig, Etty Bitton, Jaya Dantam, Lyndon Jones, William Ngo, Michael T. M. Wang
Summary: This study evaluated the short-term tolerability of five commercially available anti-demodectic eyelid cleansers, finding that different cleanser formulations may induce ocular discomfort, tear film instability, conjunctival hyperaemia, and ocular surface staining during application.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Ophthalmology
Anat Galor, Alexis Ceecee Britten-Jones, Yun Feng, Giulio Ferrari, David Goldblum, Preeya K. Gupta, Jesus Merayo-Lloves, Kyung-Sun Na, Shehzad A. Naroo, Kelly K. Nichols, Eduardo M. Rocha, Louis Tong, Michael T. M. Wang, Jennifer P. Craig
Summary: Various factors in mental, physical, and social health domains have been linked to ocular surface diseases, particularly dry eye disease (DED). Mental health factors such as depression and anxiety, and medications used to treat them, have been associated with DED symptoms. Sleep disorders and physical health issues like obesity and face mask wear have also been linked to DED. Societal factors, such as tobacco use, cocaine, and alcohol, have been associated with tear instability, decreased corneal sensitivity, and tear film disturbances and DED symptoms, respectively.
Review
Ophthalmology
Daniel A. R. Scott, Michael T. M. Wang, Helen Danesh-Meyer, Sarah Hull
Summary: Optic atrophy is a significant cause of visual impairment in children, and the underlying causes have changed over time. Prematurity has become an increasingly common cause of optic atrophy, likely due to the rising rates of premature births and improved survival of preterm infants. However, there is limited research on this topic with small sample sizes and methodological limitations, calling for larger, better-designed studies to understand the contribution of prematurity to the disease burden. Screening for prematurity should be considered when evaluating pediatric optic atrophy, alongside other potential life-threatening causes.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Editorial Material
Ophthalmology
Michael T. M. Wang, Alexis Ceecee Britten-Jones, Jennifer P. Craig
JAMA OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Joevy Z. Lim, Akilesh Gokul, Stuti L. Misra, Peter W. Hadden, Alana Cavadino, Charles N. J. McGhee
Summary: This large-scale study on uveal melanoma (UM) in New Zealand reveals that UM predominantly affects Europeans, followed by indigenous Maori, Asians, and Pacific Peoples, with no eye or sex predilection. The 1-, 5-, and 10-year survival rates from all-cause mortality were 94%, 68%, and 51%, and disease-specific survival rates were 97%, 79%, and 71% respectively. Age, UM arising from nonspecified sites, and mixed cell UM were associated with an increased risk of disease-specific mortality. Despite government-funded public eye care and increasing research and awareness, the burden of UM in New Zealand remains comparable to global studies, particularly in the Maori population.
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Cameron Schauer, Joshua Quon, Pravin Potdar, Ashwin Singh, Dean Croft, Michael Wang
Summary: This study aimed to compare alcohol-related hospital presentations during the COVID-19 restriction periods in New Zealand with corresponding control periods from the previous year. The results showed that there was no change in alcohol-related presentations during the strictest lockdown period, but there was a higher proportion of acute mental and behavioral disorders. New Zealand appears to have avoided the general trend of increased alcohol-related harms seen internationally during the COVID-19 pandemic and its lockdown restrictions.
NEW ZEALAND MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Bhavesh Dayal Lallu, Jae Beom Hong, Michael Wang, John Chalissery, Roger Blume, Jeanette Langridge, Sarah Davidson, Heather Webb, P. Alan Barber
Summary: This study compares the process metrics and outcomes of patients transferred for stroke clot retrieval (SCR) from regional and metropolitan areas to Auckland City Hospital. The results indicate that regional patients can achieve similar SCR outcomes to metropolitan patients.
NEW ZEALAND MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Cameron Schauer, Michael Chieng, Michael Wang, Michelle Neave, Sarah Watson, Marius Van Rijnsoever, Russell Walmsley, Ali Jafer
Summary: AI-assisted colonoscopy significantly improved adenoma detection rate compared with conventional colonoscopy, while there was no significant difference in overall polyp detection rate. However, further research is needed to understand its impact on long-term clinical outcomes.
NEW ZEALAND MEDICAL JOURNAL
(2022)