Article
Rehabilitation
Youn Ji Kim, Bo Ryun Kim, Sang Rim Kim, Kwang Woo Nam, So Young Lee, Jun Hwan Choi, Won Bin Kim, Beom Su Kim
Summary: Comorbidities, especially osteoporosis and diabetes, have an impact on the short-term functional outcomes of patients 3 months after total knee arthroplasty. Taking comorbidities into consideration can help better understand the potential risks during the postoperative rehabilitation process.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Rehabilitation
Youn Ji Kim, Bo Ryun Kim, Sang Rim Kim, Kwang Woo Nam, So Young Lee, Jun Hwan Choi, Won Bin Kim, Beom Su Kim
Summary: The study aimed to determine the impact of comorbidities on physical function and quality of life of patients 3 months after total knee arthroplasty. Results showed that osteoporosis and diabetes can negatively affect short-term functional outcomes in patients after total knee arthroplasty.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Review
Rehabilitation
Matthieu Courtine, Abderrahmane Bourredjem, Anais Gouteron, Isabelle Fournel, Placido Bartolone, Emmanuel Baulot, Paul Ornetti, Pierre Martz
Summary: This systematic literature review investigates the influence of body mass index (BMI) on functional recovery after total hip replacement (THR) or total knee replacement (TKR). The findings show that obesity has a certain impact on functional recovery in the short-term, medium-term, and long-term after THR or TKR.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yangguang Chen, Junguo Wang, Shuoqi Li, Yinghao Li
Summary: This study found that combining blood flow restriction with single-leg low load resistance exercise and high load resistance exercise can increase myogenesis-related hormone levels in women with unilateral knee osteoarthritis.
Article
Geriatrics & Gerontology
Chun-De Liao, Hung-Chou Chen, Tsan-Hon Liou, Che-Li Lin, Shih-Wei Huang
Summary: This study investigated the associations of sarcopenia, obesity, and their combination with walking disability during postoperative rehabilitation in older adults with knee osteoarthritis who underwent total knee replacement. The results showed that sarcopenia, obesity, or the combination of both may lead to decreased postoperative walking ability. These findings are important for developing rehabilitation strategies, especially for patients preoperatively diagnosed with sarcopenic obesity.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Medicine, General & Internal
Maria T. Schwabe, Charles P. Hannon
Summary: Total knee arthroplasty (TKA) is a common procedure that has recently seen increased interest in cementless TKA. Modifications in design and implant materials/coatings have improved bone in growth and stability, making it suitable for younger and overweight patients. Cementless TKA has shown better survivorship and cost effectiveness, but there is still debate over which implant is superior.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Robert A. Sershon, Kevin B. Fricka, William G. Hamilton, Dennis Nam, Nancy L. Parks, Anne DeBenedetti, Craig J. Della Valle
Summary: This study compared the early outcomes of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA). The results showed that UKA had shorter operative times and length of stay, and there were no significant differences between UKA and TKA in patient-reported outcome measures, duration of opioid use, or return to work.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Medicine, General & Internal
Riccardo Giorgino, Alessandra Nannini, Edoardo Scuttari, Alessandro Nuara, Ricardo Ciliberto, Corrado Sosio, Paolo Sirtori, Giuseppe M. Peretti, Laura Mangiavini
Summary: This study evaluated short-term clinical, psychological and functional outcomes in patients undergoing total knee replacement with kinematic alignment technique. The results showed that this technique allows for fast postoperative recovery and good clinical, psychological, and functional results in a short time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Chun-De Liao, Shih-Wei Huang, Yu-Yun Huang, Che-Li Lin
Summary: The study found a strong association between sarcopenic obesity and knee osteoarthritis (KOA), which may impact the recovery outcomes of older patients undergoing total knee replacement (TKR). Furthermore, patients with sarcopenic obesity had a higher risk of poor range of motion (ROM) recovery following TKR surgery.
Article
Anesthesiology
Alexandra Sideris, Michael-Alexander Malahias, George Birch, Haoyan Zhong, Valeria Rotundo, Brian J. Like, Miguel Otero, Peter K. Sculco, Meghan Kirksey
Summary: This study investigated the cytokine profiles of patients undergoing TKA and found significant differences in four cytokines among those who developed persistent postoperative pain. Lower levels of IL-10 in prearthrotomy synovial fluid were associated with the development of persistent pain.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ahmad Almhdie-Imjabbar, Hechmi Toumi, Khaled Harrar, Antonio Pinti, Eric Lespessailles
Summary: This study presents a model based on X-ray trabecular bone texture analysis, clinical and radiological information to predict the risk of total knee arthroplasty (TKA) in patients with or at risk of developing knee osteoarthritis (KOA). The model achieved a good performance with high sensitivity and specificity in identifying at-risk patients, increasing TKA case prediction by 60% as reflected by the recall values.
SCIENTIFIC REPORTS
(2022)
Review
Engineering, Biomedical
Patricia Gabielli Vassao, Julia Parisi, Thaise Fernanda Campos Penha, Ana Beatriz Balao, Ana Claudia Muniz Renno, Mariana Arias Avila
Summary: This review found that there is controversy on the effects of PBMT associated with exercises for pain and functional capacity improvement for people with KOA, mainly due to the heterogeneity between studies in related to PBMT parameters and exercise protocols.
LASERS IN MEDICAL SCIENCE
(2021)
Review
Rehabilitation
Kristin J. Konnyu, Louise M. Thoma, Wangnan Cao, Roy K. Aaron, Orestis A. Panagiotou, Monika Reddy Bhuma, Gaelen P. Adam, Dan Pinto, Ethan M. Balk
Summary: This study systematically reviewed the evidence on prehabilitation interventions for patients undergoing elective knee or hip arthroplasty for osteoarthritis. Thirteen knee arthroplasty trials suggested that prehabilitation may improve strength and reduce hospital stay without increasing harms, but there was insufficient evidence for pain, range of motion, and daily activities. There was no evidence or insufficient evidence for all outcomes of hip arthroplasty.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Rehabilitation
Naaja Petersson, Stian Langgard Jorgensen, Troels Kjeldsen, Inger Mechlenburg, Per Aagaard
Summary: This study investigates the feasibility and effects of blood flow restricted walking exercise in patients with knee osteoarthritis. The results show that blood flow restricted walking exercise is feasible and can improve functional performance in knee osteoarthritis patients, with no significant changes in self-reported function.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Article
Health Care Sciences & Services
Andre F. Steinert, Lennart Schroeder, Lukas Sefrin, Bjoern Janssen, Joerg Arnholdt, Maximilian Rudert
Summary: This study analyzed patient-reported and functional outcomes of patients with tricompartimental knee osteoarthritis treated with a customized cruciate-retaining total knee arthroplasty. The study found that patients reported high overall satisfaction and improvement in functional outcomes within the first year from surgery, which continued over the following years.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Orthopedics
Bo Bregenhof, Per Aagaard, Nis Nissen, Mark W. Creaby, Jonas Bloch Thorlund, Carsten Jensen, Trine Torfing, Anders Holsgaard-Larsen
Summary: For patients with persistent hamstring strength deficits after ACL reconstruction, 12 weeks of supervised progressive strength training was found to be more effective than low-intensity home-based exercises for improving maximal knee flexor muscle strength and some patient-reported outcomes.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2023)
Article
Sport Sciences
H. Paul Dijkstra, Sean Mc Auliffe, Clare L. Ardern, Joanne L. Kemp, Andrea Britt Mosler, Amy Price, Paul Blazey, Dawn Richards, Abdulaziz Farooq, Andreas Serner, Eugene McNally, Vasco Mascarenhas, Richard W. Willy, Jason L. Oke, Karim M. Khan, Sion Glyn-Jones, Mike Clarke, Trisha Greenhalgh
Summary: This study aims to establish research priorities for conditions affecting the young person's hip with primary cam morphology, providing guidance for more rigorous and evidence-based research in this area, and reducing the cost and burden of hip disease related to primary cam morphology.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Editorial Material
Sport Sciences
H. Paul Dijkstra, Sean Mc Auliffe, Clare L. Ardern, Joanne L. Kemp, Andrea Britt Mosler, Amy Price, Paul Blazey, Dawn Richards, Abdulaziz Farooq, Andreas Serner, Eugene McNally, Vasco Mascarenhas, Richard W. Willy, Ivan Stankovic, Jason L. Oke, Karim M. Khan, Sion Glyn-Jones, Mike Clarke, Trisha Greenhalgh
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Respiratory System
Sofie Langbo Salling, Janne Hastrup Jensen, Sebastian Breddam Mosegaard, Lotte Sorensen, Inger Mechlenburg
Summary: Patients undergoing major surgery are at increased risk of developing post-operative pulmonary complications. A risk prediction score was validated in this study, but was found to have limited discriminative ability. However, clinically relevant risk factors for developing complications were identified.
CLINICAL RESPIRATORY JOURNAL
(2023)
Article
Hematology
Joaquin Calatayud, Daniel C. Ogrezeanu, Juan J. Carrasco, Eduardo Martinez-Valdes, Sofia Perez-Alenda, Carlos Cruz-Montecinos, Lars L. Andersen, Per Aagaard, Luis Suso-Marti, Jose Casana
Summary: This study aimed to compare the safety, feasibility, and neuromuscular activity of low-load resistance exercise with/without blood flow restriction (BFR) in people with severe hemophilia. The results showed that BFR did not cause pain increases or adverse events, and there were no significant changes in neuromuscular activity. Therefore, it is safe and feasible for these patients to perform exercise with low load and appropriate BFR.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Physiology
Tobias Goetschi, Victoria Held, Gianna Klucker, Barbara Niederoest, Per Aagaard, Joerg Spoerri, Fabian S. Passini, Jess G. Snedeker
Summary: Prolonged periods of increased physical demands can cause both positive and negative adaptations in tendons, depending on the underlying mechanisms. The PIEZO1 ion channel has been implicated in tendon mechanotransduction and the E756del gain-of-function variant has been linked to improved jumping performance. This study found that carrying the E756del gene variant was associated with increased patellar tendon stiffness in humans, but there was no correlation between tendon stiffness and jumping performance.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Thomas Frydendal, Kristine Sloth Thomsen, Inger Mechlenburg, Lone Ramer Mikkelsen, Soren Overgaard, Kim Gordon Ingwersen, Cornelius Myburgh
Summary: This qualitative case study explored the perceptions of patients, clinicians, and decision-makers on a clinical trial comparing the effectiveness of total hip arthroplasty (THA) with exercise. The study identified two main themes: "Treatment expectations and beliefs impact management choices" and "Factors influencing clinical trial integrity and feasibility." The findings demonstrate the importance of involving patients and the public in the development of trial protocols to reduce bias in comparative clinical trials.
Review
Physiology
M. H. Hjortshoej, P. Aagaard, C. D. Storgaard, H. Juneja, J. Lundbye-Jensen, S. P. Magnusson, C. Couppe
Summary: This study evaluated the hormonal, immune, and oxidative stress responses in healthy adults following low-load blood-flow restricted resistance exercise (LL-BFRRE) and conventional free-flow resistance exercise (FFRE). The results showed that LL-BFRRE induced higher hormone and immune responses compared to FFRE, and had attenuated oxidative stress responses compared to HL-FFRE.
Article
Rehabilitation
Michael J. M. O'Brien, Joshua Heerey, Adam Ivan Semciw, Inger Mechlenburg, Julie S. Jacobsen, Matthew G. King, Mark J. Scholes, Peter R. Lawrenson, Kay Crossley, Rintje Agricola, Richard B. Souza, Joanne L. Kemp
Summary: This study compared hip muscle strength and functional performance in football players with and without hip dysplasia, and found no differences between the two groups. This may be due to the milder hip dysplasia in the cohort or the beneficial effects of football participation on muscle strength and functional performance in individuals with hip dysplasia.
PHYSICAL THERAPY IN SPORT
(2023)
Article
Orthopedics
Mette Holm Hjorth, Inger Mechlenburg, Kjeld Soballe, Lone Romer, Stig Storgaard Jakobsen, Maiken Stilling
Summary: This study investigated the influence of the anterolateral and the posterior surgical approaches on the location, grade, and prevalence of pseudotumors and muscle atrophy in metal-on-metal resurfacing hip arthroplasty (MoM RHA). The results showed that pseudotumors were mainly located anterolaterally in the anterolateral group and postero-laterally in the posterior group. Muscle atrophy of the gluteus medius, gluteus minimus, and small external rotators differed between the two groups. Metal-ion concentrations and clinical outcome scores were similar between groups.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Orthopedics
Louise Mortensen, Inger Mechlenburg, Stian Langgard Jorgensen
Summary: This case study provides evidence that low-load blood-flow-restriction exercise (LL-BFRE) may be a feasible intervention to preserve skeletal muscle mass and improve lower-limb muscle function after a fracture of the lateral malleolus. A 28-year-old female patient performed 12 weeks of home-based LL-BFRE with no exercise-related adverse events and experienced minimal pain. Vastus lateralis muscle volume, and thigh and calf circumference were maintained.
CLINICAL JOURNAL OF SPORT MEDICINE
(2023)
Article
Medicine, General & Internal
Antti P. Launonen, Bakir O. Sumrein, Aleksi Reito, Vesa Lepola, Juha Paloneva, Hans E. Berg, Li Fellander-Tsai, Kristo Kask, Timo Rahnel, Kaspar Tootsi, Aare Martson, Kenneth B. Jonsson, Olof Wolf, Peter Strom, Kaj Dossing, Helle K. Ostergaard, Inger Mechlenburg, Ville M. Mattila, Minna K. Laitinen
Summary: This multicenter, randomized trial investigated the efficacy of surgical and non-surgical treatments for displaced 3- and 4-part proximal humerus fractures (PHFs) in patients aged 60 years and older. The study found that there was no significant benefit observed with surgical treatment using locking plates (LP) or hemiarthroplasty (HA) compared to nonoperative treatment. Additionally, surgical treatments were associated with a high rate of complications. The trial was limited by premature termination.
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)
Article
Medicine, General & Internal
Inger Mechlenburg, Torsten Gronbech Nielsen, Nick Kristensen, Andreas Bentzen, Stian Langgard Jorgensen
Summary: This study investigates the use of low-load resistance training with concurrent blood flow restriction as a rehabilitation method for anterior knee pain. The results demonstrate significant improvements in muscle strength and mass without exacerbation of knee-joint pain, allowing patients to return to their usual training regime.
SAGE OPEN MEDICAL CASE REPORTS
(2023)