Article
Clinical Neurology
Ratthaporn Boonsuth, Rebecca S. Samson, Carmen Tur, Marco Battiston, Francesco Grussu, Torben Schneider, Masami Yoneyama, Ferran Prados, Antrea Ttofalla, Sara Collorone, Rosa Cortese, Olga Ciccarelli, Claudia A. M. Gandini Wheeler-Kingshott, Marios C. Yiannakas
Summary: This study aimed to assess peripheral nervous system (PNS) damage in people with relapsing-remitting MS (RRMS) using magnetisation transfer ratio (MTR) imaging at the lumbar plexus and sciatic nerve anatomical locations. The results showed significantly lower MTR values in the sciatic nerve of RRMS patients compared to healthy controls, but no significant changes were identified in the lumbar plexus.
FRONTIERS IN NEUROLOGY
(2021)
Article
Anesthesiology
Mathias Maagaard, Emma R. Stormholt, Lasse F. Nielsen, Finn Baerentzen, Jakob Danker, Josephine Zachodnik, Pia Jaeger, Ole Mathiesen, Jakob H. Andersen
Summary: The authors conducted a study to investigate the effect of perineural and systemic dexamethasone as adjuncts to bupivacaine on the duration of an ulnar nerve block. They found that perineural dexamethasone resulted in a longer block duration compared to placebo, while systemic dexamethasone showed no significant difference compared to placebo. These findings suggest that perineural dexamethasone may be an effective adjunct to prolong the duration of ulnar nerve blocks.
Article
Gastroenterology & Hepatology
Xiao Jing Wang, Duane D. Burton, Margaret Breen-Lyles, Michael Camilleri
Summary: This study found that postprandial gastric accommodation is significantly associated with the rate of gastric emptying, with higher gastric volumes leading to prolongation of emptying. The study also introduced novel methods to measure proximal gastric accommodation and correct for radioisotope upscatter.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Chemistry, Analytical
Skaidre Jankovskaja, Maxim Morin, Anna Gustafsson, Chris D. Anderson, Boglarka Lehoczki, Johan Engblom, Sebastian Bjorklund, Meinda Rezeli, Gyorgy Marko-Varga, Tautgirdas Ruzgas
Summary: This study assessed various sampling approaches for tryptophan and kynurenine and found that the phenylalanine/tryptophan ratio may be a possible alternative biomarker for non-invasive skin cancer detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Immunology
Federico E. Turkheimer, Noha Althubaity, Julia Schubert, Maria A. Nettis, Oliver Cousins, Danai Dima, Valeria Mondelli, Edward T. Bullmore, Carmine Pariante, Mattia Veronese
Summary: The studies suggest that peripheral inflammation may lead to a reduction in blood-brain barrier permeability, disrupting brain homeostasis and inducing depressive symptoms.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Ratthaporn Boonsuth, Marco Battiston, Francesco Grussu, Christina Maria Samlidou, Alberto Calvi, Rebecca S. Samson, Claudia A. M. Gandini Wheeler-Kingshott, Marios C. Yiannakas
Summary: Magnetic resonance neurography (MRN) has been successfully used to investigate the peripheral nervous system (PNS) by early detecting and accurately locating neural tissue damage. Combining MRN with multi-parametric quantitative magnetic resonance imaging (qMRI) methods, which provide specific information on nerve tissue composition and microstructural organization, is invaluable. This study aimed to assess the feasibility of combining MRN with qMRI to measure diffusion, magnetization transfer, and relaxation properties of the healthy sciatic nerve in vivo. The findings pave the way for the practical implementation of joint MRN-qMRI in future studies of PNS pathological conditions.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Arturo Zancan, Stefania Sozzi, Marco Schieppati
Summary: This study evaluated the feasibility and effectiveness of a walking protocol based on a figure-of-eight path across different age groups. Results showed that in the older age group, walking speed on the figure-of-eight path was significantly slower than on the linear path, with shorter step length and smaller walk ratio.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanns-Christian Breit, Jan Vosshenrich, Verena Hofmann, Thilo Rusche, Balazs K. Kovacs, Michael Bach, Sebastian Manneck, Dorothee Harder
Summary: This study assessed the potential of a 0.55T low-field MRI system in lumbar spine imaging and found that the image quality at 0.55T was lower compared to 1.5T. However, the use of advanced postprocessing techniques improved the imaging quality and the interrater agreement was good.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adam Maunder, Ho-Fung Chan, Paul J. C. Hughes, Guillhem Collier, Graham Norquay, Oliver Rodgers, Peter Thelwall, Fraser Robb, Madhwesha Rao, Jim M. Wild
Summary: The study measured the transverse relaxation time (T-2*) and apparent diffusion coefficient (ADC) of F-19 C3F8 gas in human lungs at 1.5T and 3T, showing a significant increase in ADC from functional residual capacity (FRC) to total lung capacity (TLC). The T-2* values of F-19 C3F8 exhibited a consistent distribution pattern in the lungs of healthy volunteers, with lower values near the diaphragm and larger pulmonary vessels.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Paolo Mulatero, Michael Groessl, Bruno Vogt, Christoph Schumacher, Ronald Edward Steele, Ashley Brooks, Stuart Hossack, Hans-Rudolf Brunner
Summary: This study evaluated the safety and efficacy of a novel aldosterone synthase inhibitor in healthy participants. The results showed that the inhibitor effectively suppressed aldosterone production and improved sodium balance, making it a valuable option for managing aldosterone-dependent hypertension and primary aldosteronism.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Motoki Arakawa, Takayuki Watanabe, Koya Suzuki, Junichi Nishino, Hiromitsu Sekizuka, Toshiyuki Iwahori, Shin-Ichi Ono, Shinji Hidaka
Summary: The method utilizing overnight urine for estimating daily salt intake may result in overestimation during low-salt diet and underestimation during high-salt diet. On the other hand, the daily mean of the casual urinary Na/K ratio reflects salt intake changes more accurately and can serve as a practical marker, particularly in short-term interventions.
ANNALS OF NUTRITION AND METABOLISM
(2021)
Article
Anesthesiology
Sandeep Diwan, Abhishek Lonikar, Himaunshu Dongre, Parag Sancheti, Abhijit Nair, Suhrud Panchawagh
Summary: This study compared lumbar erector spinae plane block (LESPB) and lumbar plexus block (LPB) for pain management and clinical outcomes in patients undergoing proximal femoral nail (PFN) for proximal femoral fractures (PFF). The results showed that LESPB group had better average pain scores over 24 hours, with a lower proportion of patients requiring opioids compared to the LPB group. Additionally, the time for the first request of parenteral analgesia was longer in the LESPB group, and there were a few cases of quadriceps weakness, but no incidences of hemodynamic instability and respiratory complications.
SAUDI JOURNAL OF ANAESTHESIA
(2023)
Article
Medicine, General & Internal
Calvin Gan, Patricia L. Robertson, Jeffrey K. C. Lai, Jeff Szer
Summary: This study assessed the reproducibility of the LiverLab tool for evaluating bone marrow fat fraction (FF) and its ability to differentiate between Gaucher disease (GD) patients and healthy subjects. The results showed excellent reproducibility of LiverLab FF measurements and the ability to differentiate between GD patients and healthy subjects. However, the lack of statistical difference between GD patients and controls may be due to the limited number of subjects, active treatment, or mild disease severity in untreated patients.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Clinical Neurology
B. T. Pushpa, S. Rajasekaran, Murugesh Easwaran, Chandhan Murugan, Raksha Algeri, K. S. Sri Vijay Anand, Rishi Mugesh Kanna, Ajoy Prasad Shetty
Summary: This study used MRS and T2r to quantitatively assess the dynamic changes of Lactate in lumbar discs under different physiological conditions. The results showed that there was a distinct difference in the lactate response to exercise, with Grade 1 discs exhibiting a significant decrease immediately after exercise and a trend towards normalization after 60 minutes. In contrast, Grade 2 and 3 discs and discs above 40 years old showed a higher lactate content relative to proteoglycan at rest, an increase in lactate after exercise, and a mild decrease after 60 minutes. Following nimodipine intake, Grade 1 discs showed an increase in lactate, while Grade 2 and 3 discs did not show any change. Furthermore, exercise and nimodipine had no significant effect on the T2r values and MRS spectrum of other metabolites. These findings suggest that lactate response could be a dynamic radiological biomarker of early degeneration.
EUROPEAN SPINE JOURNAL
(2023)
Article
Chemistry, Medicinal
Marina Oshiro-Sembokuya, Shinya Uchida, Yasuharu Kashiwagura, Maika Ashihara, Shimako Tanaka, Takao Hashimoto, Chiyo Kokubu, Noriyuki Namiki
Summary: Oral mucositis is a common adverse effect in cancer treatments, and foam formulations containing drugs have shown potential in preventing and treating oral mucositis. Different foam densities and drug concentrations have varying effects in the oral cavity, with SM-4 foam having the longest disappearance time and best palatability. Drug-containing foam formulations prepared with 1-4% SM-4 were found to have satisfactory drug contents and properties.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2021)
Editorial Material
Clinical Neurology
Yael Hacohen, Olga Ciccarelli
Article
Clinical Neurology
Marcello Moccia, Lukas Haider, Arman Eshaghi, Steven Harry Pieter van de Pavert, Vincenzo Brescia Morra, Amy Patel, Claudia Angela Michela Wheeler-Kingshott, Frederik Barkhof, Olga Ciccarelli
Summary: Perivascular B cells in progressive multiple sclerosis are associated with worse clinical outcomes and CNS inflammation.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Vivien Li, Baptiste Leurent, Frederik Barkhof, Marie Braisher, Fay Cafferty, Olga Ciccarelli, Arman Eshaghi, Emma Gray, Jennifer M. Nicholas, Mahesh Parmar, Guy Peryer, Jenny Robertson, Nigel Stallard, James Wason, Jeremy Chataway
Summary: This article introduces how to accelerate the evaluation of new therapies for progressive multiple sclerosis (PMS) using the multi-arm multistage (MAMS) platform trial. Through the review of past PMS trials and simulation trials, the selection and design measures for interim and final outcomes are determined. To reduce the duration and sample size, the proposed MAMS trial design is recommended to replace traditional clinical trials.
Article
Radiology, Nuclear Medicine & Medical Imaging
Emma Biondetti, Anita Karsa, Francesco Grussu, Marco Battiston, Marios C. Yiannakas, David L. Thomas, Karin Shmueli
Summary: This study compared different multi-echo combination methods for MRI QSM and recommended combining the signal phase by nonlinear fitting before applying LBMs to improve regional accuracy and reduce phase noise.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Review
Neurosciences
Alberto Redolfi, Damiano Archetti, Silvia De Francesco, Claudio Crema, Fabrizio Tagliavini, Raffaele Lodi, Roberta Ghidoni, Claudia A. M. Gandini Wheeler-Kingshott, Daniel C. Alexander, Egidio D'Angelo
Summary: Neuroinformatics is a research field that focuses on software tools for identifying, analyzing, modeling, organizing, and sharing neuroscience data. With the emergence of big data, neuroinformatics has experienced rapid growth in the past two decades, enabling neuroscientists to acquire and process data faster and more cost-effectively. To address this, neuroimaging-focused neuroinformatics platforms have been developed, aiming to archive and organize data, develop data-driven models, and provide computational and storage resources.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Maria A. Rocca, Paola Valsasina, Alessandro Meani, Claudio Gobbi, Chiara Zecca, Frederik Barkhof, Menno M. Schoonheim, Eva M. Strijbis, Hugo Vrenken, Antonio Gallo, Alvino Bisecco, Olga Ciccarelli, Marios Yiannakas, Alex Rovira, Jaume Sastre-Garriga, Jacqueline Palace, Lucy Matthews, Achim Gass, Philipp Eisele, Carsten Lukas, Barbara Bellenberg, Monica Margoni, Paolo Preziosa, Massimo Filippi
Summary: Spinal cord damage and, to a lesser extent, cortical volume loss are associated with worse 5-year clinical outcomes in multiple sclerosis patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Gilbert Thomas-Black, Daniel R. Altmann, Harry Crook, Nita Solanky, Ferran Prados Carrasco, Marco Battiston, Francesco Grussu, Marios C. Yiannakas, Baris Kanber, Jasleen K. Jolly, Jon Brett, Susan M. Downes, Marni Moran, Ping K. Chan, Emmanuel Adewunmi, Claudia A. M. Gandini Wheeler-Kingshott, Andrea H. Nemeth, Richard Festenstein, Fion Bremner, Paola Giunti
Summary: This study comprehensively evaluated the degeneration of the retina in FRDA patients and found heterogeneity in different retinal sectors. The thickness of the retinal nerve fiber layer was associated with frataxin levels. These findings have implications for future clinical trial design.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Wallace J. Brownlee, Carmen Tur, Andreea Manole, Arman Eshaghi, Ferran Prados, Katherine A. Miszkiel, Claudia A. M. Gandini Wheeler-Kingshott, Henry Houlden, Olga Ciccarelli
Summary: This study found that HLA-DRB1*1501 is associated with the severity of multiple sclerosis (MS), as indicated by long-term disability worsening and greater extent of inflammatory disease activity and tissue loss. HLA-DRB1*1501 may provide useful information for prognosis and treatment decisions in early relapse-onset MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Editorial Material
Clinical Neurology
Jose G. R. Merino, Olga O. Ciccarelli, Bradford Worrall, Whitley W. Aamodt, Anthony Amato, Rebecca A. Burch, Peter C. Hedera, Linda M. Hershey, Barbara Jobst, Amy C. E. Kunchok, Andrea L. C. Schneider, Renee A. Shellhaas, Roy Strowd
Editorial Material
Clinical Neurology
Olga Ciccarelli, Ahmed T. Toosy, Alan Thompson, Yael Hacohen
Summary: The Lancet Neurology((R)) published international criteria for the diagnosis of myelin oligodendrocyte glycoprotein-associated disease (MOGAD) on January 24, 2023. According to these criteria, patients with clinical events typically associated with MOG antibody (Ab) and clear positive serum MOG-Ab results can be diagnosed with MOGAD. Patients with low positive serum MOG-Ab titers can also be diagnosed if they possess supporting clinical or MRI features. Exclusion of alternative diagnoses, including multiple sclerosis (MS), is required.
Editorial Material
Clinical Neurology
Jose G. Merino, Andrea L. C. Schneider, Olga Ciccarelli
Summary: Neurology aims to publish important research questions and use robust methods with transparent reporting. They rely on internal and external peer reviewers as well as methods experts to evaluate manuscripts. Drs. Kryscio, Leurgans, and Pankratz have been dedicated to evaluating these manuscripts for many years.
Article
Clinical Neurology
Alberto Calvi, Zoe Mendelsohn, Weaam Hamed, Declan Chard, Carmen Tur, Jon Stutters, David MacManus, Baris Kanber, Claudia A. M. Gandini Wheeler-Kingshott, Frederik Barkhof, Ferran Prados
Summary: This study retrospectively analyzed a fingolimod trial in patients with primary progressive MS (PPMS) and found that newly appearing lesions are common and can develop into chronic active lesions. Treatment can reduce the number of these lesions.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rebecca R. Baker, Vivek Muthurangu, Marilena Rega, Javier Montalt-Tordera, Samuel Rot, Bhavana S. Solanky, Claudia A. M. Gandini Wheeler-Kingshott, Stephen B. Walsh, Jennifer A. Steeden
Summary: This study validated the use of 2D sodium MRI with half-sinc excitation and compressed sensing (CS) for quantifying tissue sodium concentration (TSC) with a resolution of 2.25 x 2.25 mm(2) and scan times of <= 5 mins.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neuroimaging
Nicola De Stefano, Marco Battaglini, Deborah Pareto, Rosa Cortese, Jian Zhang, Niels Oesingmann, Ferran Prados, Maria A. Rocca, Paola Valsasina, Hugo Vrenken, Claudia A. M. Gandini Wheeler-Kingshott, Massimo Filippi, Frederik Barkhof, Alex Rovira
Summary: There is an increasing need to share harmonized data from large, cooperative studies for the development of new diagnostic and prognostic biomarkers. In the field of multiple sclerosis (MS), the harmonization of acquisition, analysis, and storage of large-scale multicentre MRI data is of paramount importance. Despite the advances made, further research and specialized resources are required to address the complexity of these tasks.
NEUROIMAGE-CLINICAL
(2022)
