Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Article
Medicine, General & Internal
Malia S. Q. Murphy, Samantha J. Benton, Brian Cox, Kara Nerenberg, Scott McComb, Lakshmi Krishnan, Risini D. Weeratna, Jean-Francois Pare, Alysha L. J. Dingwall-Harvey, Shannon A. Bainbridge, Andree Gruslin, Laura M. Gaudet
Summary: Women who develop preeclampsia are at high risk for cardiovascular disease. This study investigates the potential of cytokine and immune cell profiles in distinguishing low and high cardiovascular disease risk in the early postpartum period.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lizhu Chen, Yun Xiu, Qijun Wu, Yu Wang, Yixin Zhang, Jia Xue, Qinbo Wang, Zhengwei Yuan
Summary: This study found that maternal serum LMNA may serve as a potential biomarker for prenatal diagnosis of fetal CHD, NTD, and PE.
Article
Ecology
Loke von Schmalensee, Katrin Hulda Gunnarsdottir, Joacim Naslund, Karl Gotthard, Philipp Lehmann
Summary: This study demonstrates that it is challenging to predict the temperature dependence of performance traits in ectotherms in natural environments, despite being feasible in controlled laboratory settings. The research shows that accurate predictions of development rates in butterflies can be made in the field using models parameterized under constant laboratory temperatures, but this accuracy depends on considering non-linearity in reaction norms, spatial heterogeneity in microclimate, and temporal variation in temperature across microhabitats. Additionally, insect development rates are generally unaffected by thermal fluctuations, discounting direct effects of temperature.
Article
Medicine, General & Internal
Emmanuel Bujold, Alexandre Fillion, Florence Roux-Dalvai, Marie Pier Scott-Boyer, Yves Giguere, Jean-Claude Forest, Clarisse Gotti, Genevieve Laforest, Paul Guerby, Arnaud Droit
Summary: This study demonstrated that maternal urine proteomic profiling can differentiate women with and without preeclampsia. Specific proteins like ceruloplasmin and serpin A7 were upregulated in maternal urine before the diagnosis of preeclampsia and fetal growth restriction, suggesting their potential role as biomarkers for early detection.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Shuang Yu, Changan Liu, Yingtong Hou, Jie Li, Zhuming Guo, Xinwen Chen, Luyao Zhang, Sui Peng, Shubin Hong, Lixia Xu, Xiaoxing Li, Rengyun Liu, Shuwei Chen, Bin Li, Zongpeng Weng, Yanbing Li, Weiming Lv, Jun Yu, Haipeng Xiao
Summary: Discriminating papillary thyroid cancer (PTC) from benign thyroid nodule (BTN) is challenging, but this study identified a panel of 17 differential metabolites that can effectively differentiate between the two. The panel showed high sensitivity and specificity in both discovery and validation cohorts, and it also improved the accuracy and specificity for diagnosing papillary thyroid microcarcinoma compared to ultrasound.
Article
Multidisciplinary Sciences
Sarita Devi, Roshni M. Pasanna, Nikhil Nadiger, Santu Ghosh, Anura V. Kurpad, Arpita Mukhopadhyay
Summary: The study found that the duration of tourniquet application significantly affects the variability in plasma metabolite concentrations, recommending minimizing tourniquet application time and waiting for 5 minutes after removal to reduce variability and false interpretations.
SCIENTIFIC REPORTS
(2021)
Article
Reproductive Biology
Danyi Liu, Guorong Lyu, Hongwei Lai, Liya Li, Yaduan Gan, Shuping Yang
Summary: By retrospectively collecting data from 393 patients who met the inclusion criteria, we found that ultrasound MCP can accurately predict BOTs. Indicators that could well identify BOT in different pathological types of tumors were derived by multivariate unordered logistic regression analysis. The correlation between ultrasound MCP and pathological features was analyzed.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Neurosciences
Zhiyi Chen, Rong Zhang, Jiawei Xie, Peiwei Liu, Chenyan Zhang, Jia Zhao, Justin Paul Laplante, Tingyong Feng
Summary: This study developed a hybrid brain model that accurately identified trait procrastination and revealed the neural hallmarks of this trait by integrating neuroimaging fusion data.
COGNITIVE NEURODYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Sona Rivas-Tumanyan, Lorena S. Pacheco, Danielle E. Haslam, Liming Liang, Katherine L. Tucker, Kaumudi J. Joshipura, Shilpa N. Bhupathiraju
Summary: This study assessed the longitudinal associations between plasma metabolites, their network-derived clusters, and the progression of type 2 diabetes (T2D) in Puerto Rican adults. The findings highlight potential prognostic biomarkers for identifying high-risk individuals and suggest the need for further research on the role of diet and lifestyle in modifying these associations.
Article
Obstetrics & Gynecology
Abbey P. Donahue, Angelica Glover, Robert A. Strauss, William H. Goodnight, Catherine J. Vladutiu, Tracy A. Manuck
Summary: This study examined the levels of maternal plasma inflammatory cytokines in midtrimester and their association with preterm birth among patients with a cervical cerclage. The study found that elevated levels of inflammatory cytokines were associated with earlier delivery and could estimate the probability of preterm birth.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Food Science & Technology
Linyuan Shen, Jianfeng Ma, Haodi Zhou, Lei Chen, Jie Tang, Kaige Zhang, Ye Zhao, Lili Niu, Shunhua Zhang, Anan Jiang, Jinyong Wang, Zongyi Guo, Xuewei Li, Yiwu Chen, Mailin Gan, Li Zhu
Summary: This study aimed to identify biomarkers for pork quality evaluation. The pH of pork meat was found to be negatively correlated with meat color indicators, and differential metabolites were enriched in amino acid and energy metabolism pathways. Correlation analysis revealed potential plasma biomarkers for predicting pork quality based on pH value.
Article
Cell Biology
Margarita L. Martinez-Fierro, Idalia Garza-Veloz
Summary: The study evaluated serum microRNA expression profiling and identified multiple microRNAs involved in preeclampsia development, affecting various signaling pathways. Specific microRNAs were differentially expressed in the serum of pregnant women before the development of preeclampsia.
Article
Cardiac & Cardiovascular Systems
Elena Gibbone, Iulia Huluta, Alan Wright, Kypros H. Nicolaides, Marietta Charakida
Summary: This study examines the differences in cardiac function between women who develop preeclampsia (PE) and those with uncomplicated pregnancies. The findings suggest that women who develop PE have abnormalities in cardiac function long before the onset of PE. However, routine cardiac assessment at midgestation does not improve the performance of screening for PE achieved by established biomarkers.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Chemistry, Physical
Giovanna Bruno, Bernardo de Souza, Frank Neese, Giovanni Bistoni
Summary: This article proposes a computational strategy for accurate calculation of singlet-triplet gaps of aromatic compounds, which achieves excellent agreement with experimental data.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)