Article
Immunology
Tirza Gabrielle Ramos de Mesquita, Jose do Espirito Santo Junior, Luan Diego Oliveira da Silva, George Allan Villarouco Silva, Felipe Jules de Araujo, Suzana Kanawati Pinheiro, Herllon Karllos Athaydes Kerr, Lener Santos da Silva, Luciane Macedo de Souza, Samir Assad de Almeida, Krys Layane Guimaraes Duarte Queiroz, Josue Lacerda de Souza, Cilana Chagas da Silva, Hector David Graterol Sequera, Mara Lucia Gomes de Souza, Anderson Nogueira Barbosa, Gemilson Soares Pontes, Marcus Vinitius de Farias Guerra, Rajendranath Ramasawmy
Summary: The immunopathology associated with Leishmaniasis is a consequence of inflammation that may lead to different clinical manifestations depending on host-immune response type, with various pathways influencing disease severity. Comparing immune profiles in patients with cutaneous leishmaniasis caused by L. guyanensis and healthy individuals helps identify specific immune factors related to disease development progression. Multiple biomarker pairs showed high correlation, with cytokines IL-17 and IL-1 beta exhibiting the most positive pair correlation among patients. Prediction of disease progression in Lg-infected individuals may be associated with specific cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Idris Mhaidi, Mouad Ait Kbaich, Sofia El Kacem, Othmane Daoui, Khadija Akarid, Tatiana Spitzova, Petr Halada, Vit Dvorak, Meryem Lemrani
Summary: This study in Morocco identified sand fly fauna in Ibaraghen village and confirmed the role of P. sergenti as a vector in the Azilal focus of cutaneous leishmaniasis. The relative abundance of other potential vector species also emphasizes the risk of introducing L. infantum and L. major in the province. This is the first combined approach in Morocco to identify sand flies using both morphology and molecular methods.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Hedvig Glans, Leif Dotevall, Gert Van der Auwera, Aldert Bart, Johannes Blum, Pierre Buffet, Romain Guery, Jean-Pierre Gangneux, Saskia van Henten, Gundel Harms, Stefania Varani, Florence Robert-Gangneux, Robert Rongisch, Bjorn Andersson, Maria Bradley
Summary: This article describes and evaluates the treatment outcomes of cutaneous leishmaniasis (CL) among travelers and migrants in Europe caused by Leishmania major and Leishmania tropica. The study found that L. major infections were mostly found in individuals visiting friends and relatives, while L. tropica infections were mainly identified in migrants. Pentavalent antimony had a cure rate of 73% (L. major) and 78% (L. tropica) among patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Yasser Alraey, Rasha Alhweti, Hatim Almutairi, Abdulrahman Abdullah Al-Qahtani, Mohammed Ibrahim Alshahrani, Mohammed Hussin Asiri, Abdulrhman Mousa Alhammas, Saeed Jubran Alwagdi, Abdulaziz Alshahrani, Abdulaziz Alouffi, Aymen M. Madkhali, Waleed S. Al-Salem, Ahmed A. Al-Qahtani, Ahmed Saif, Sami Ben Hadj Ahmed, Elyes Zhioua
Summary: This study analyzed the epidemiological features of cutaneous leishmaniasis in southern Saudi Arabia, finding that the majority of patients originated from Khamis-Mushait and Abha, with a higher proportion of male patients and a higher incidence in children under 13 years old. The co-circulation of ACL and ZCL highlights the complexity of the disease's epidemiology, necessitating further research for control strategies.
Article
Infectious Diseases
Patricia Gijon-Robles, Naima Abattouy, Gemma Merino-Espinosa, Nora El Khalfaoui, Francisco Morillas-Marquez, Victoriano Corpas-Lopez, Noureddine Jaaouani, Victoriano Diaz-Saez, Myriam Riyad, Joaquina Martin-Sanchez
Summary: The study compared the densities and genetic characteristics of Phlebotomus sergenti populations in two nearby localities in Morocco, finding differences in both density and mitochondrial lineage which may explain the different epidemiological situations. The absence of a specific P. sergenti lineage in the non-endemic area could be the main factor for its nonendemic status, despite having sufficient density to support transmission.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Multidisciplinary Sciences
Mounia Amane, Mohamed Echchakery, Mohamed Daoudi, Mohamed Hafidi, Samia Boussaa
Summary: Leishmaniasis is endemic in Morocco, and this study identified several socioeconomic and environmental factors associated with anthroponotic cutaneous leishmaniasis (ACL), such as rural habitation, movement to endemic areas, provenance from leishmaniasis foci, poverty, proximity to vegetation, poor domestic hygiene, and presence of animals. Marital status was also found to be associated with ACL. These risk factors should be considered for multidisciplinary collaboration and community participation in disease prevention.
Article
Microbiology
Arezki Izri, Amina Bendjaballah-Laliam, Denis Sereno, Mohammad Akhoundi
Summary: This study investigated the geographical distribution of Leishmania spp. causing cutaneous affection in Algeria, identifying L. major as the most common parasite among patients. Utilizing microscopy, PCR, and PCR-RFLP techniques, the presence of multiple Leishmania species was confirmed, providing additional insights into the epidemiology of cutaneous leishmaniasis in Algeria.
Review
Microbiology
Mehdi Bamorovat, Iraj Sharifi, Razieh Tavakoli Oliaee, Abdollah Jafarzadeh, Ahmad Khosravi
Summary: The study highlights the importance of implementing effective preventive and therapeutic measures for CL patients who do not respond to treatment, especially in endemic areas. Regular monitoring of drug unresponsiveness is essential for ACL patients, particularly in tropical regions where the disease is prevalent.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Nasreddine Saidi, Yousr Galai, Meriem Ben-Abid, Thouraya Boussoffara, Ines Ben-Sghaier, Karim Aoun, Aida Bouratbine
Summary: The study aimed to develop a direct immunofluorescence (DIF) assay for visualization of L. major antigens and evaluate its reliability in the routine diagnosis of CL. The DIF assay showed high sensitivity and specificity, and was more sensitive than microscopy.
Article
Microbiology
Othmane Daoui, Hamza Bennaid, Mouad Ait Kbaich, Idris Mhaidi, Nacer Aderdour, Hassan Rhinane, Souad Bouhout, Khadija Akarid, Meryem Lemrani
Summary: This study assessed the impact of climatic and environmental factors on Cutaneous leishmaniasis (CL) due to Leishmania tropica in Morocco. It also investigated the population structure of L. tropica in three different foci. The results showed a correlation between temperature and humidity with CL incidence in Imintanout, and high genetic diversity in Foum Jemaa and Imintanout.
Article
Dermatology
Michal Solomon, Shoshana Greenberger, Maya Milner, Felix Pavlotzky, Aviv Barzilai, Eli Schwartz, Noa Hadayer, Sharon Baum
Summary: The effectiveness and safety of systemic treatments for L. tropica cutaneous leishmaniasis were evaluated in a retrospective study. Liposomal amphotericin B was found to be the treatment of choice, demonstrating favorable treatment responses and better safety profile.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Public, Environmental & Occupational Health
Michal Solomon, Ariel Gimple, Inbal Fuchs, Assi Cicurel, Tal Meninger, Dror Avni, Abed Nasereddin, Charles L. Jaffe, Eli Schwartz
Summary: The study aimed to investigate the prevalence of Leishmania in the blood of patients with active or previous cutaneous leishmaniasis (CL). The findings of this pilot study suggest that people with active or recent CL caused by L. major and L. tropica do not harbor parasites in their blood. Hence, their exclusion from blood donation should be revisited.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Pharmacology & Pharmacy
Bassel Awada, Maguy Hamie, Rana El Hajj, Ghada Derbaj, Rania Najm, Perla Makhoul, Dima Hajj Ali, Antoine G. G. Abou Fayad, Hiba El Hajj
Summary: Cutaneous Leishmaniasis is a neglected tropical disease and a major health concern in the Eastern Mediterranean Region. The use of natural products as potential treatments for Leishmania tropica is explored, highlighting the need for new therapies to combat the disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Multidisciplinary
Lei Zhang, Mati Ur Rahman, Qu Haidong, Muhammad Arfan, Adnan
Summary: This paper presents an analysis of an Anthroponotic Cutaneous Leishmania infection using the Caputo fractal-fractional operator. By applying fractal-fractional calculus techniques, the study demonstrates the significance of fractional order derivatives in understanding the complexity of the dynamics of the proposed Leishmania model through numerical simulations and comparisons with real data. The research shows that fractal-fractional order derivatives are more informative in studying the dynamics of the infection.
ALEXANDRIA ENGINEERING JOURNAL
(2022)
Article
Multidisciplinary Sciences
Mehdi Bamorovat, Iraj Sharifi, Esmat Rashedi, Alireza Shafiian, Fatemeh Sharifi, Ahmad Khosravi, Amirhossein Tahmouresi
Summary: Cutaneous leishmaniasis is a major health burden in tropical and subtropical regions. This study used machine learning techniques to classify cases and found that the duration of skin lesion is the most influential factor in treatment responsiveness. The MLP model showed promising results for rapid detection and effective treatment.
Article
Dermatology
Ahmad Reza Taheri, Vahid Mashayekhi-Goyonlo, Maryam Salehi, Hamideh Mohammadzadeh
LASERS IN SURGERY AND MEDICINE
(2020)
Article
Dermatology
Yalda Nahidi, Vahid Mashayekhi Goyonlo, Pouran Layegh, Faezeh Taghavi, Mona Najaf Najafi
Summary: This study aimed to investigate the efficacy of adding diphencyprone immunotherapy to conventional meglumine antimoniate treatment for acute urban cutaneous leishmaniasis (CL), and found that the combination therapy resulted in earlier resolution of acute CL lesions with a relatively acceptable rate of adverse effects.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Yasaman Taslimi, Christopher Agbajogu, Siggeir Fannar Brynjolfsson, Nasrin Masoudzadeh, Vahid Mashayekhi, Safoora Gharibzadeh, Malin Ostensson, Sravya Sowdamini Nakka, Amir Mizbani, Sima Rafati, Ali M. Harandi
Article
Dermatology
Vahid Mashayekhi Goyonlo, Maryam Saeidi Sardabi, Arezoo Moradi Tavalaei, Zahra Khoshnevisan, Mahdi Razmara
Summary: This study aimed to compare the effectiveness of cognitive behavioral therapy (CBT) as an adjuvant treatment for acne excoriee (AE). The results showed that patients in the CBT group exhibited significant improvements in clinical severity score, self-reported skin picking scale (SPS) score, and depression and anxiety scores compared to the control group.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Engineering, Biomedical
Zahra Tafazzoli, Yalda Nahidi, Vahid Mashayekhi Goyonlo, Negar Morovatdar, Pouran Layegh
Summary: The study found that intense pulsed light with wavelength spectrum affecting vascular lesions was less effective than intralesional MA in the treatment of cutaneous leishmaniasis. However, it can be considered as a second-line option, especially for patients with limitations for the use of MA.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Negar Seyed, Sima Rafati
Summary: Leishmaniasis is a global health problem with Th1 response playing a crucial role in disease control. Vaccine formulations aimed at generating long-lived memory Th1 response have not been effective against sand fly transmitted infection except for leishmanization. Recent studies have shown that sand fly dependent factors may compromise pre-existing Th1 memory, while Th1 concomitant immunity has a prominent role in controlling secondary infections delivered by sand fly.
Article
Biochemistry & Molecular Biology
Neda Moazzezy, Elham Rismani, Maryam Rezaei, Mohammad Reza Asadi Karam, Sima Rafati, Saeid Bouzari, Mana Oloomi
Summary: The development of bacterial resistance to antibiotics has led to the attention of antimicrobial peptides (AMPs). This study computationally investigated the interaction between derived peptides and bacterial membrane and found that the derived peptides could exhibit similar antimicrobial effects to HNP-1. Furthermore, chemical modifications improved the physicochemical properties of the peptides and retained similar binding affinity.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Correction
Parasitology
Fatemeh Khadir, Tahereh Taheri, Sima Habibzadeh, Farnaz Zahedifard, Elham Gholami, Maryam Heidari-Kharaji, Ahmad Oryan, Sima Rafati
VETERINARY PARASITOLOGY
(2021)
Article
Parasitology
Atefeh Sadeghi Shermeh, Farnaz Zahedifard, Sima Habibzadeh, Tahereh Taheri, Sima Rafati, Negar Seyed
Summary: The study found that the DC prime-DNA boost vaccine can induce Th1 polarization immune response, but its effectiveness in fighting infection is limited.
EXPERIMENTAL PARASITOLOGY
(2021)
Article
Infectious Diseases
Masoumeh Tayyebi, Emadodin Darchini-Maragheh, Pouran Layegh, Bita Kiafar, Vahid Mashayekhi Goyonlo
Summary: Leishmaniasis is a common disease in Iran, with cutaneous leishmaniasis being a major health concern. Some patients show resistance to traditional treatment methods like meglumine antimoniate. Oral miltefosine may serve as an effective alternative treatment.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Renuka Bhor, Sima Rafati, Kalpana Pai
Summary: In humans, infection with Leishmania results in a spectrum of diseases, with parasite evasion of macrophage immune responses being a key mechanism. Studies have shown that cell-mediated immunity plays a crucial role in the development and resolution of leishmaniasis.
Article
Immunology
Mehrdad Shokouhy, Hamzeh Sarvnaz, Yasaman Taslimi, Mahya Sadat Lajevardi, Sima Habibzadeh, Amir Mizbani, Faezeh Shekari, Mandana Behbahani, Ana Claudia Torrecilhas, Sima Rafati
Summary: This study reports for the first time that L. tarentolae can release EVs and provides evidence that tEVs are able to control the infection in human macrophages, making them a great potential platform for drug delivery, at least for parasitic infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemical Research Methods
Yasaman Taslimi, Nasrin Masoudzadeh, Fariborz Bahrami, Sima Rafati
Summary: Cutaneous leishmaniasis (CL) is the most frequent form of leishmaniases, associated with skin inflammation and ulceration. Understanding the interaction of different phagocytic cells in the recognition and uptake of different Leishmania species is critical for controlling the infection.
EXPERT REVIEW OF PROTEOMICS
(2022)
Article
Medicine, General & Internal
Maryam Mahdavi, Reihaneh Aryan, Yalda Nahidi, Mehrdad Teimoorian, Vahid Mashayekhi
Summary: Clinicians should always consider the possibility of rare, atypical, and opportunistic infections in patients undergoing long-term systemic corticosteroid therapy, and diagnosis requires further evaluation and special consideration.
CLINICAL CASE REPORTS
(2021)
