4.6 Review

A Short Overview on the Biomedical Applications of Silica, Alumina and Calcium Phosphate-based Nanostructured Materials

Journal

CURRENT MEDICINAL CHEMISTRY
Volume 23, Issue 39, Pages 4450-4467

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867323666161024153459

Keywords

Nanoparticles; silica; alumina; calcium phosphate; drug-delivery; biomedical

Funding

  1. FEDER
  2. Ministerio de Economia y Competitividad, Spain [CTQ2015-66164-R]
  3. Universidad Rey Juan Carlos
  4. Banco de Santander

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This article reviews the use of silica, alumina and calcium phosphate-based nanostructured materials with biomedical applications. A short introduction on the use of the materials in Science, Nanotechnology and Health is included followed by a revision of each of the selected materials. A description of the principal synthetic methods used in the preparation of the materials in nanostructured form is included. The most widely used applications in biomedicine are reviewed including, for example drug-delivery, bone regeneration, imaging, sensoring amongst others. Finally, a short description of the toxicity and cytotoxicity associated with each of the materials of this revision is presented. This short literature revision serves to demonstrate the very promising future ahead of nanosystems based on silica, alumina and calcium phosphate for biological and biomedical applications.

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