Journal
NUTRIENTS
Volume 12, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/nu12113234
Keywords
obesity; diet; high-fat diet; diet-induced thermogenesis; body mass index; rodents
Categories
Funding
- Ministry of Spain (MINECO) (ERDF) [SAF2017-83813-C3-1-R]
- Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN) [CB06/03/0001]
- Government of Catalonia [2017SGR278]
- Fundacio La Marato de TV3 [201627-30]
- CONICYT-ANID Chile
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Obesity and its associated metabolic diseases are currently a priority research area. The increase in global prevalence at different ages is having an enormous economic and health impact. Genetic and environmental factors play a crucial role in the development of obesity, and diet is one of the main factors that contributes directly to the obesogenic phenotype. Scientific evidence has shown that increased fat intake is associated with the increase in body weight that triggers obesity. Rodent animal models have been extremely useful in the study of obesity since weight gain can easily be induced with a high-fat diet. Here, we review the dietary patterns and physiological mechanisms involved in the dynamics of energy balance. We report the main dietary options for the study of obesity and the variables to consider in the use of a high-fat diet, and assess the progression of obesity and diet-induced thermogenesis.
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