Article
Biotechnology & Applied Microbiology
Chuwei Zhang, Qingrong Zhang, Dongmei Yang, Yating Qiao, Bolin Wang, Jun Yan, Zihan Li, Zhanghao Huang, Youlang Zhou, Kesu Hu, Yi Zhang
Summary: Burns can impair skin barrier function and have high mortality rates. Chitooligosaccharides (COS) have potential in burn wound therapy by promoting wound healing through regulation of the MAPK pathway and HGF.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Omid Yazarlu, Mehrdad Iranshahi, Hamid Reza Khayat Kashani, Sara Reshadat, Solomon Habtemariam, Milad Iranshahy, Maede Hasanpour
Summary: Herbal medicines play a significant role in wound healing by stimulating various mechanisms such as reepithelialization, angiogenesis, and collagen fiber deposition. Some herbal medicines also exhibit antioxidant and anti-inflammatory properties by inhibiting specific protein expression. Compared to conventional medicines, herbal medicine and natural products offer advantages in wound healing due to their diverse mechanisms of action, antibacterial activity, and long-term safety in usage.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Engineering, Chemical
Prima F. Hillman, Chaeyoung Lee, Sang-Jip Nam
Summary: Wound healing is challenging in clinical settings and requires proper management. Acute wound healing involves cell divisions, formation of extracellular matrix, and the release of growth factors and cytokines. Factors like infection and inflammation can delay healing, and natural products have shown potential in promoting wound healing. This review discusses the research on wound healing activities of natural microbial products, aiming to contribute to the development of better wound treatments.
Article
Pharmacology & Pharmacy
Ying Wang, Zhuo Feng, Meifeng Yang, Lin Zeng, Bu'er Qi, Saige Yin, Bangsheng Li, Yilin Li, Zhe Fu, Longjun Shu, Chen Fu, Pan Qin, Yi Meng, Xiaojie Li, Ying Yang, Jing Tang, Xinwang Yang
Summary: Despite challenges in skin wound treatment, a novel short peptide RL-QN15 from frog skin secretions was discovered to accelerate wound healing in mice by modulating cytokine secretion and activating signaling pathways. This peptide showed therapeutic potency against chronic wounds, skin fibrosis, and oral ulcers, highlighting its potential as a candidate for novel pro-healing agents.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Polymer Science
Mohamadreza Tavakoli, Sheyda Labbaf, Marjan Mirhaj, Saeideh Salehi, Alexander Marcus Seifalian, Mahboubeh Firuzeh
Summary: Natural biopolymers, such as carbohydrates and proteins, are widely used in wound healing due to their biocompatibility and similarity to the extracellular matrix. Chitosan has shown the most clinical application among carbohydrates, while keratin has not yet found clinical use compared to chitosan.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Review
Endocrinology & Metabolism
Xiaoping Yu, Pan Liu, Zheng Li, Zhengdong Zhang
Summary: Diabetes is a global public health problem, with diabetic foot being one of its severe complications that have a significant impact on patients' economic burden and quality of life. Recent studies have shown that mesenchymal stem cells (MSCs) can effectively treat diabetic foot ulcers by promoting angiogenesis and re-epithelialization, regulating the immune response, and reducing inflammation. MSCs from different sources have similar characteristics and subtle differences, and understanding their features is crucial for improving the therapeutic effect of diabetic foot ulcers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Luisa A. DiPietro, Traci A. Wilgus, Timothy J. Koh
Summary: Macrophages play a prominent role in skin wound healing, with functions including host defense and support of new tissue growth. However, the exact role of macrophages in wound healing remains elusive, as some wounds can heal well even with limited or no functional macrophages. Recent advances in understanding macrophage phenotypes and cellular plasticity in wounds may provide new insights and paradigms on macrophage function in wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Merce Iruela Sanchez, Rosa Garcia-Sierra, Rafael Medrano-Jimenez, Diana Bonachela-Mompart, Natalia Maella-Rius, Esther Soria-Martin, Mar Isnard-Blanchar, Pere Toran-Monserrat
Summary: We aim to investigate the relationship between temperature differences between the wound bed and perilesional skin and the healing process in primary care patients with wounds. This study is a multisite prospective cohort study with one-year follow-up, conducted from January 2023 to September 2023 in the Metropolitan North area of Barcelona. Variables such as percentage reduction of wound area over time, thermal index, Kundin Wound Gauge, and Resvech 2.0 Scale will be measured. Weekly temperature checks will be done using a handheld thermometer and mesh grid. Healing trajectory will be monitored through photographic imaging, the Resvech Scale, calculation of wound size, percentage reduction of wound area over time, and thermal index for one year or until the wound is cured. This study has the potential to improve the management of chronic wounds in primary care by facilitating early diagnosis of wound complications.
Article
Engineering, Biomedical
Hanif Haidari, Richard Bright, Xanthe L. Strudwick, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: This study presents the development of a multifunctional thermo-responsive hydrogel utilizing ultra-small silver nanoparticles for controlled and optimized delivery of silver to infected wounds. The developed hydrogel showed significant elimination of S. aureus from mouse wounds, promoting cell proliferation and wound re-epithelization. The multifunctional properties of the AgNP thermoresponsive hydrogel offer great clinical potential in controlling bacterial infections and promoting wound healing.
ACTA BIOMATERIALIA
(2021)
Review
Immunology
Meirong Li, Qian Hou, Lingzhi Zhong, Yali Zhao, Xiaobing Fu
Summary: The review highlights the persistent hyper-inflammation as a distinguishing characteristic of chronic wounds, with macrophage malfunction identified as a major contributor. The study explores the origin, heterogeneity, and dysregulation of macrophages in wound healing, while also evaluating therapeutic approaches for restoring macrophage response. Multidimensional analysis using high-throughput technologies helps assess the diversity, activation states, and communication of macrophages in healing and non-healing wounds, providing promising interventions for chronic wounds.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Dalibor Mijaljica, Fabrizio Spada, Daniel J. J. Klionsky, Ian P. P. Harrison
Summary: As a highly regulated and dynamic intracellular degradation mechanism, autophagy plays an essential role in skin wound healing at different stages. It operates at different levels and is modulated based on the conditions of wound healing, contributing to rapid and efficient healing. Enhancing autophagy through the localized application of pro-autophagy biologics, such as hydrogels, can provide moisture and immune modulation, creating a conducive environment for skin wound healing.
Review
Pharmacology & Pharmacy
E. Liu, Hongjin Gao, YiJia Zhao, Yaobing Pang, Yejing Yao, Zhengru Yang, Xueer Zhang, YanJin Wang, Siming Yang, Xiao Ma, Jinhao Zeng, Jing Guo
Summary: Under normal circumstances, wound healing can be summarized as three processes: inflammation, proliferation, and remodeling. However, there is still a lack of significant research on nonhealing wounds. This study highlights the mechanisms and targets of natural products (NPs) for treating nonhealing wounds and summarizes 25 NPs that contribute to wound healing, providing research ideas for the development of new wound healing products.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rachael L. Moses, Thomas A. K. Prescott, Eduard Mas-Claret, Robert Steadman, Ryan Moseley, Alastair J. Sloan
Summary: Chronic, non-healing wounds are a significant and growing medical problem worldwide. They greatly impact patients' quality of life and impose a heavy economic burden due to their difficulty and time-consuming treatment. Natural remedies containing bioactive small molecules show potential in promoting wound healing and combating antibiotic-resistant bacteria. However, more well-conducted clinical trials are needed to confirm their efficacy and advance these remedies to clinical use.
Article
Biochemistry & Molecular Biology
Xiaosu Huang, Junhua Yang, Renyue Zhang, Lianbao Ye, Ming Li, Weiqiang Chen
Summary: Globally, wound infection, particularly bacterial infections like MRSA, poses a significant healthcare challenge. This study demonstrates that PD hydrogel may be a safe and effective treatment option for MRSA-infected wounds, improving wound healing, reducing inflammation, and decreasing bacterial load.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Stefania Vitale, Sara Colanero, Martina Placidi, Giovanna Di Emidio, Carla Tatone, Fernanda Amicarelli, Anna Maria D'Alessandro
Summary: This study summarizes recent research on herbal preparations for wound management, finding that several herbal medicaments have activity at different stages, with components such as flavonoids, alkaloids, saponins, and phenolic compounds contributing to this activity. The application of natural compounds using nanotechnology systems may significantly improve the efficacy of wound treatments.
Article
Plant Sciences
Anna Vuorinen, Julia Seibert, Vassilios P. Papageorgiou, Judith M. Rollinger, Alex Odermatt, Daniela Schuster, Andreana N. Assimopoulou
Article
Oncology
Qiaoli Zhao, Andreana N. Assimopoulou, Sabine M. Klauck, Harilaos Damianakos, Ioanna Chinou, Nadine Kretschmer, Jose-Luis Rios, Vassilios P. Papageorgiou, Rudolf Bauer, Thomas Efferth
Article
Biochemistry & Molecular Biology
E. D. Spyrelli, A. V. Kyriazou, C. Virgiliou, A. Nakas, O. Deda, V. P. Papageorgiou, A. N. Assimopouloua, H. G. Gika
MOLECULAR BIOSYSTEMS
(2017)
Article
Biochemical Research Methods
Jasmin Tappeiner, Alexandra Vasiliou, Markus Ganzera, Dimitrios Fessas, Hermann Stuppner, Vassilios P. Papageorgiou, Andreana N. Assimopoulou
BIOMEDICAL CHROMATOGRAPHY
(2014)
Article
Food Science & Technology
Konstantinos N. Kontogiannopoulos, Andreana N. Assimopoulou, Konstantinos Dimas, Vassilios P. Papageorgiou
EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
(2011)
Article
Chemistry, Applied
Stella A. Ordoudi, Stella K. Tsermentseli, Nikolaos Nenadis, Andreana N. Assimopoulou, Maria Z. Tsimidou, Vassilios P. Papageorgiou
Article
Pharmacology & Pharmacy
Konstantinos N. Kontogiannopoulos, Andreana N. Assimopoulou, Ioannis Tsivintzelis, Costas Panayiotou, Vassilios P. Papageorgiou
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2011)
Article
Pharmacology & Pharmacy
Konstantinos N. Kontogiannopoulos, Andreana N. Assimopoulou, Sophia Hatziantoniou, Kostas Karatasos, Costas Demetzos, Vassilios P. Papageorgiou
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2012)
Article
Biochemical Research Methods
Stella K. Tsermentseli, Panagiotis Manesiotis, Andreana N. Assimopoulou, Vassilios P. Papageorgiou
JOURNAL OF CHROMATOGRAPHY A
(2013)
Article
Biochemistry & Molecular Biology
Rasmus K. Petersen, Kathrine B. Christensen, Andreana N. Assimopoulou, Xavier Frette, Vassilios P. Papageorgiou, Karsten Kristiansen, Irene Kouskoumvekaki
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
(2011)
Article
Biochemistry & Molecular Biology
K. N. Kontogiannopoulos, S. K. Tsermentseli, A. N. Assimopoulou, V. P. Papageorgiou
JOURNAL OF LIPOSOME RESEARCH
(2014)
Article
Polymer Science
Afroditi Kapourani, Konstantinos N. N. Kontogiannopoulos, Alexandra-Eleftheria Manioudaki, Athanasios K. K. Poulopoulos, Lazaros Tsalikis, Andreana N. N. Assimopoulou, Panagiotis Barmpalexis
Summary: Xerostomia refers to the subjective sensation of oral dryness, which is multifactorial and commonly caused by the use of xerostomic medications, neck and head radiation, and systematic diseases. It is associated with increased incidence of dental caries, oral fungal infections, and difficulties in speaking and chewing/swallowing, ultimately affecting the oral health-related quality of life. Successful management of xerostomia is challenging due to the complexity of saliva, but polymers play a crucial role in various formulations, especially in saliva substitutes.
Article
Food Science & Technology
Maria Marinaki, Ioannis Sampsonidis, Alexandros Nakas, Panagiotis Arapitsas, Andreana N. Assimopoulou, Georgios Theodoridis
Summary: This study aimed to characterize the volatilome of Tsipouro products and found that Tsipouro from different regions and production styles has a high aroma variability. Aniseed spirits from Northern Greece, Macedonia, Limnos Island, and Thessaly were found to be rich in terpenes, terpenoids, and flavored compounds. Different terpenoids were dominant in Muscat distillates from different regions, showing the importance of geographical origin and production process. These results could contribute to better protection of the origin of Tsipouro and improvement of its quality.
Proceedings Paper
Materials Science, Multidisciplinary
Vassilis Zaspalis, Spiros V. Paras, Andreana N. Assimopoulou, Christos Chatzidoukas, Ioannis Tsivintzelis
MATERIALS TODAY-PROCEEDINGS
(2018)