Review
Endocrinology & Metabolism
Xuemin Peng, Yong Chen
Summary: The relationship between circadian rhythms and thermogenic fat and its potential in treating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Nazmul Hasan, Naoto Nagata, Jun-ichi Morishige, Md Tarikul Islam, Zheng Jing, Ken-ichi Harada, Michihiro Mieda, Masanori Ono, Hiroshi Fujiwara, Takiko Daikoku, Tomoko Fujiwara, Yoshiko Maida, Tsuguhito Ota, Shigeki Shimba, Shuichi Kaneko, Akio Fujimura, Hitoshi Ando
Summary: This study demonstrates the impact of impaired BAT clock on energy metabolism and obesity development. Disruption of BAT clock helps maintain normal core body temperatures but may lead to reduced energy expenditure and obesity development.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Alba Sabate-Perez, Montserrat Romero, Paula Sanchez-Fernandez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Josep A. Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacin, Xavier Testar, Antonio Zorzano
Summary: The study reveals a novel molecular mechanism by which TP53INP2 regulates PPARG activity and brown adipogenesis through autophagy, and demonstrates the importance of TP53INP2 in maintaining thermogenic capacity and preventing lipid accumulation in brown adipose tissue. These findings provide insights into the therapeutic strategies against obesity and its metabolic complications.
Article
Food Science & Technology
Mingzhu Yan, Suwei Jin, Zhi Wang, Tianji Xia, Yongguang Liu, Qi Chang
Summary: Limonin, a compound found in citrus fruits, has been found to effectively combat obesity by reducing fat mass and body weight gain, and improving fatty liver and hyperlipidemia caused by a high-fat diet. It also promotes the browning of white adipose tissues and prevents the whitening of brown adipose tissue in mice. These effects are associated with the activation of PGC-1 alpha pathway. Overall, limonin shows great potential for regulating energy balance and treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Jian-Jun Meng, Jia-Wei Shen, Guang Li, Chang-Jie Ouyang, Jia-Xi Hu, Zi-Shuo Li, Hang Zhao, Yi-Ming Shi, Mei Zhang, Rong Liu, Ju-Tao Chen, Yu-Qian Ma, Huan Zhao, Tian Xue
Summary: Public health studies have shown that artificial light is a high-risk factor for metabolic disorders, but the neural mechanism by which light affects metabolism is not well understood. This study found that light can rapidly decrease glucose tolerance in mice by activating retinal ganglion cells that connect to the hypothalamic supraoptic nucleus. This neural circuit ultimately blocks adaptive thermogenesis in brown adipose tissue, leading to reduced glucose tolerance. Similar effects were observed in humans, suggesting a potential strategy for managing glucose metabolic disorders.
Review
Cell Biology
Chelsea Hepler, Joseph Bass
Summary: In this article, the authors focus on the new insights into the plasticity of adipocytes and the circadian control of adipose tissue metabolism, transcription, and inflammation. They also discuss the recent studies that uncover the mechanistic links between clocks and adipocyte metabolism, as well as its application to dietary and behavioral interventions for improving health and mitigating obesity. The circadian clock plays a crucial role in coordinating feeding and metabolic rhythms, and disrupting the clock is associated with increased adiposity and metabolic disorders.
GENES & DEVELOPMENT
(2023)
Review
Endocrinology & Metabolism
Isabel Heyde, Kimberly Begemann, Henrik Oster
Summary: The text discusses the role of adipose tissue in the circadian regulation of energy metabolism, with white and brown adipose tissue playing different roles in energy regulation through the release of endocrine factors and heat production. Adipose tissue rhythms are regulated by systemic signals and local clocks, impacting metabolic homeostasis. Disruption of circadian rhythms in adipose tissue can lead to obesity and related issues, highlighting the importance of stabilizing adipose tissue rhythms for combatting disrupted energy homeostasis and obesity.
Article
Biochemistry & Molecular Biology
Mueez U-Din, Eleni Rebelos, Teemu Saari, Tarja Niemi, Katharina Kuellmer, Olli Eskola, Tobias Fromme, Johan Rajander, Markku Taittonen, Martin Klingenspor, Pirjo Nuutila, Lauri Nummenmaa, Kirsi A. Virtanen
Summary: The expression of uncoupling protein 1 (UCP-1) in supraclavicular brown adipose tissue (BAT) is directly related to brain metabolism during cold stress. This relationship is observed in various brain regions, such as the hypothalamus, medulla, and frontal lobe. Future research is needed to determine the clinical implications of these findings, particularly in relation to cognitive functions under cold stress.
Review
Biochemistry & Molecular Biology
Zhengyan Zhang, Di Yang, Junwei Xiang, Jingwen Zhou, Hua Cao, Qishi Che, Yan Bai, Jiao Guo, Zhengquan Su
Summary: Thermogenic organs in mammals play a crucial role in increasing heat production and energy regulation. Targeting specific signalling pathways to enhance energy expenditure via brown adipose tissue may be a potential strategy for treating obesity and related diseases. Studies have shown that various natural products can promote thermogenesis through different signalling pathways, offering potential for future research on weight-loss nutraceuticals or drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Hang Cheng, Rajaa Sebaa, Nikita Malholtra, Baptiste Lacoste, Ziyad El Hankouri, Alexia Kirby, Nigel C. Bennett, Barry van Jaarsveld, Daniel W. Hart, Glenn J. Tattersall, Mary-Ellen Harper, Matthew E. Pamenter
Summary: Naked mole-rats, among the most hypoxia-tolerant mammals, decrease their body temperature in low oxygen conditions through reduced brown adipose tissue thermogenesis, driven by decreases in the key thermogenic mitochondrial protein UCP1. This down-regulation of thermogenesis in hypoxia is associated with mitochondrial fission, inhibited apoptosis and mitophagy in brown adipose tissue, suggesting an evolved preference for rapid energy conservation in social species under low oxygen conditions.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Zhichao Wang, Qiong A. Wang, Yong Liu, Lei Jiang
Summary: Brown adipose tissue functions as an 'energy sink' in mammals, burning calories through substrates like lipids, glucose, and other metabolites to produce heat and support thermogenesis, contributing to overall metabolic homeostasis.
Article
Endocrinology & Metabolism
Oana C. Kulterer, Carsten T. Herz, Marlene Prager, Christoph Schmoeltzer, Felix B. Langer, Gerhard Prager, Rodrig Marculescu, Alexandra Kautzky-Willer, Marcus Hacker, Alexander R. Haug, Florian W. Kiefer
Summary: There is a higher prevalence of active brown adipose tissue (BAT) in lean individuals compared to obese individuals. However, the volume and activity of BAT are similar between lean and obese individuals with active BAT. In obese participants, there is a strong negative correlation between visceral fat and BAT volume, glucose uptake, and cold-induced thermogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Marie Gombert, Vanessa Martin-Carbonell, Gonzalo Pin-Arboledas, Joaquin Carrasco-Luna, Alvaro Carrasco-Garcia, Pilar Codoner-Franch
Summary: The study found that melatonin levels in children with obesity significantly increased after sleep compared to controls, and were related to fat mass. Additionally, children with obesity had shorter sleep duration and earlier waking times. Melatonin in children with obesity appears to be involved in the global metabolic and inflammatory alteration of this condition.
Review
Pharmacology & Pharmacy
Shuhui Jia, Xuantong Guo, Zuxin Chen, Shupeng Li, Xin-an Liu
Summary: Given the devastating social and health consequences of drug addiction and the limitations of current treatments, a new strategy involving correcting abnormal circadian rhythms and improving sleep quality may be beneficial in the treatment of drug addiction. Melatonin, a circadian hormone with various neuroprotective and pharmacological effects, has shown potential as an intervention for substance use disorders. This review discusses the roles of melatonin at different levels and its potential applications in drug addiction.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Xiaomeng Liu, Zhi Zhang, Yajie Song, Hengchang Xie, Meng Dong
Summary: Overweight and obesity have become global problems, with limited effective intervention approaches. Activating brown adipose tissue and browning white adipose tissue can protect against obesity and related metabolic diseases. However, important issues such as the causality between increased brown adipose tissue activity and body weight loss are still unresolved. This review comprehensively summarizes approaches to activating brown adipose tissue and/browning white adipose tissue and discusses the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Physiology
Camilla Astley, Maria Fernanda Badue Pereira, Marcos Santos Lima, Carlos Alberto Buchpiguel, Camila G. Carneiro, Marcelo Tatit Sapienza, Gabriela Nunes Leal, Danilo Marcelo Leite do Prado, Tiago Pecanha, Sofia Mendes Sieczkowska, Olivia Mari Matsuo, Livia Lindoso, Heloisa Helena Marques, Clovis Artur Silva, Bruno Gualano
Summary: This study assessed five post-discharged MIS-C survivors and found that they had impaired MBF, endothelial dysfunction, and lower cardiopulmonary capacity at follow-up analysis.
PHYSIOLOGICAL REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Milena Sales Pitombeira, Michel Koole, Kenia R. Campanholo, Aline M. Souza, Fabio L. S. Duran, Davi J. Fontoura Solla, Maria F. Mendes, Samira L. Apostolos Pereira, Carolina M. Rimkus, Geraldo Filho Busatto, Dagoberto Callegaro, Carlos A. Buchpiguel, Daniele de Paula Faria
Summary: This study used PET imaging to investigate the characteristics of microglia activation and myelin injury in different phenotypes and disability stages of multiple sclerosis. The results showed that innate immune cell characteristics and myelin loss occurred independently in both white matter and gray matter structures, and were associated with disability.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Lidia Emmanuela Wiazowski Spelta, Caroline Cristiano Real, Carlos Alberto Buchpiguel, Daniele de Paula Faria, Tania Marcourakis
Summary: We investigated the effects of cocaine-induced peripheral activation on brain [F-18]FDG uptake and proposed an optimal protocol for measuring cocaine-induced brain metabolic alterations in mice. Our findings suggest that anesthesia is essential for visualizing cocaine-induced changes in brain metabolism using [F-18]FDG PET, providing a valuable preclinical approach for studying cocaine use disorder.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Linda M. Ueno-Pardi, Fabio L. Souza-Duran, Larissa Matheus, Amanda G. Rodrigues, Eline R. F. Barbosa, Paulo J. Cunha, Camila G. Carneiro, Naomi A. Costa, Carla R. Ono, Carlos A. Buchpiguel, Carlos E. Negrao, Geraldo Lorenzi-Filho, Geraldo Busatto-Filho
Summary: Exercise training can improve exercise capacity, decrease apnea-hypopnea index, increase attention/executive functioning, and increase CMRgl in the frontal lobe of OSA patients, potentially leading to improvements in cognitive functioning.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Gleice Clemente, Alexandre W. de Souza, Hilton Leao Filho, Fernando M. A. Coelho, Carlos Buchpiguel, Marcos Lima, Camila Carneiro, Rosa M. R. Pereira, Nadia Aikawa, Clovis A. Silva, Lucia M. A. Campos, Gabriel Alves, Camilla Astley, Bruno Gualano, Maria Teresa Terreri
Summary: The study demonstrated that [18F]F-FDG-PET/MRI provided information about inflammation in vessel wall of c-TA patients. There was low concordance between PET and MRA results, with some changes being discordant between the two imaging modalities.
ADVANCES IN RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Luciana Aparecida Campos, Ovidiu Constantin Baltatu, Sergio Senar, Rym Ghimouz, Eman Alefishat, Jose Cipolla-Neto
Summary: This study explores the potential of melatonin as a therapeutic target for comorbid diseases associated with psychosocial-sleep/circadian-cardiometabolic disorders. The association between melatonin receptors and the disorders was investigated using various databases. The study also analyzed melatonin's activity in cardiovascular, neuronal, and metabolic assays. Overall, the research suggests that melatonin could be an important target for treating these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Aline Morais de Souza, Caroline Cristiano Real, Mara de Souza Junqueira, Larissa Estessi de Souza, Fabio Luiz Navarro Marques, Carlos Alberto Buchpiguel, Roger Chammas, Marcelo Tatit Sapienza, Daniele de Paula Faria
Summary: This study evaluated the potential of PET imaging with [C-11](R)-PK11195 to assess breast tumor inflammation. The results showed that [C-11](R)-PK11195 was able to identify heterogeneous tumor inflammation in a murine model of breast cancer, and the uptake varied according to tumor size.
Letter
Urology & Nephrology
Veronica T. Costa e Silva, Luiz A. Gil Jr, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro Jr, Maria D. P. Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonangelo, Lia Marcal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Uysha de S. Fonda, Andre L. A. Leitao, Marcia M. D. P. Paiva, Jose Willegaignon, Anders Josefsson, Carlos A. Buchpiguel, Marcelo T. Sapienza
Summary: This study aimed to evaluate how statistical fluctuation in SPECT images propagate to absorbed dose maps. SPECT/CT images of iodine-131 filled phantoms were evaluated using STRATOS software. Dosimetry based on single time-point SPECT images showed a linear correlation between absorbed dose map uniformity and SPECT noise. When sequential SPECTs were used, the absorbed dose COV was slightly lower compared to single SPECT image dosimetry.
NUCLEAR MEDICINE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Leanderson P. Cordeiro, Lidia de Sa, Rafael A. Kitamikado, Marcelo T. Sapienza, Daniel A. B. Bonifacio
Summary: In this study, the GATE Monte Carlo code and its variance reduction techniques were used to evaluate the calculation of S values (absorbed dose) of organs for radionuclides such as lutetium-177, iodine-131, yttrium-90, and radium-223. Comparison with data from the OpenDose collaboration showed that certain variance reduction techniques can significantly reduce simulation time while maintaining the statistical quality of the absorbed dose values, demonstrating the feasibility of the Monte Carlo method in internal dosimetry.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Editorial Material
Neurosciences
Cecilia R. A. Santos, Jose Cipolla-Neto, Markus Krohn, Isabel Goncalves, Telma Quintela
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Lia Alencar Coelho, Luciano Andrade Silva, Ana Paula Reway, Daniella Do Carmo Buonfiglio, Jessica Andrade-Silva, Patricia Rodrigues Lourenco Gomes, Jose Cipolla-Neto
Summary: Reproductive activity in mares shows a seasonal pattern, with more ovulations occurring during the spring and summer seasons. The photoperiodic control of reproduction is mediated by melatonin, which inhibits ovulatory activity. This study investigated the effect of melatonin on mare ovarian follicle development, and found that melatonin upregulates the expression of melatonin receptors and melatonin-forming enzymes, as well as increasing melatonin levels in developing follicles during the reproductive seasons.
Article
Biochemistry & Molecular Biology
Cristiane Lima Roa, Jose Cipolla-Neto, Russel J. Reiter, Iara Moreno Linhares, Ana Paula Lepique, Lana Maria de Aguiar, Isadora Braga Seganfredo, Edson Santos Ferreira-Filho, Sebastiao Freitas de Medeiros, Edmund Chada Baracat, Jose Maria Soares-Jr
Summary: This study aimed to evaluate the action of melatonin, acyclovir, or the combination of melatonin with acyclovir as a suppressive treatment for recurrent genital herpes. The findings suggest that melatonin may be an effective alternative for the suppressive therapy of recurrent genital herpes.
Article
Chemistry, Multidisciplinary
Camila M. L. Machado, Magdalena Skubal, Katja Haedicke, Fabio P. Silva, Evan P. Stater, Thais L. A. de O. Silva, Erico T. Costa, Cibele Masotti, Andreia H. Otake, Luciana N. S. Andrade, Mara de S. Junqueira, Hsiao-Ting Hsu, Sudeep Das, Benedict Mc Larney, Edwin C. Pratt, Yevgeniy Romin, Ning Fan, Katia Manova-Todorova, Martin Pomper, Jan Grimm
Summary: Cell membrane-derived particles (Mp) shed from tumor cells have the potential to be used as drug delivery vehicles for targeted and immunotherapeutic treatments. Prostate-specific membrane antigen (PSMA) is highly expressed in Mp and extracellular vesicles (EV) from prostate cancer. It has been discovered that PSMA can be transferred to the tumor microenvironment through Mp and alter cellular characteristics, resulting in increased secretion of angiogenic factors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Meeting Abstract
Psychiatry
Lais B. Razza, Carlos Buchpiguel, Fabio Duran, Stefanie De Smet, Chris Baeken, Marie-Anne Vanderhasselt, Andre R. Brunoni
PSYCHIATRIA DANUBINA
(2022)
