Article
Food Science & Technology
Yue Sun, Lin Zhou, Xiao Shan, Tiantian Zhao, Meirong Cui, Wenqian Hao, Binbin Wei
Summary: Using UPLC-QTOF/MS and plasma untargeted metabolomics analysis, this study revealed the changes in components and metabolic fluctuations of polygonatum under different processing times. The results showed that processed polygonatum exhibited changes in protein, fat, polysaccharide, flavonoids, saponins, and isoflavones. Additionally, four types of Lysophosphatidylcholines were found to be highly expressed in the plasma of rats in the SAD-9 group. Through network pharmacological analysis, it was determined that liquiritigenin and 4',5-dihydroxyflavone activated PLA2 type enzymes, promoting the production of lysophosphatidylcholine, and the SAD-9 processing method facilitated the effects of these two components.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Zhaoxiang Wang, Xiaoyi Chen, Qianqian Liu, Lin Zhang, Shuai Liu, Yingyue Su, Yamei Ren, Chunlong Yuan
Summary: This study successfully discriminated the geographical origin and vintage of wines using an untargeted metabolomic approach based on LC-IM-QTOF-MS. Wines were well discriminated according to region and vintage with OPLS-DA. Differential metabolites were screened and used for wine region and vintage discrimination, achieving an accuracy over 84.2% in the external verification trial. LC-IM-QTOF-MS-based untargeted metabolomics was demonstrated to be a feasible tool for wine geographical origin and vintage discrimination.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Asma Farjallah, Celine Gueguen
Summary: This study investigated the effects of different carbon sources on the growth and metabolism of heterotrophic Euglena gracilis cells. Metabolomics analysis revealed diverse metabolic responses to carbon source changes, with several common enriched pathways playing crucial roles in the basic metabolism of Euglena gracilis.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Food Science & Technology
Lei He, Qian Hu, Jiukai Zhang, Ranran Xing, Yongsheng Zhao, Ning Yu, Ying Chen
Summary: This study comprehensively investigated the metabolite variability of black soybeans from different geographical origins in China. The results showed that black soybeans from Gansu had higher amounts of procyanidins, epicatechin, malonylated isoflavones, and beta-pinene. Guangxi black soybeans had higher amounts of linoleic acid and its oxidation products, while Xinjiang and Yunnan black soybeans contained higher levels of delphinidin-derived anthocyanins, gamma-glutamyl peptides, and aromatic hydrocarbons. The study also identified characteristic metabolites in black soybeans from other geographical origins.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Plant Sciences
Yueyue Li, Diya Lv, Rong Liu, Yuhuan Shi, Rong Wang, Zhenyu Zhu, Yongfang Yuan
Summary: The study aimed to investigate the pharmacodynamic effects of Saposhnikovia divaricata decoction on collagen-induced arthritis (CIA) rats, and explore the therapeutic mechanism using metabolomics methods. SD showed protective effects on affected joints in CIA rats and regulated metabolic pathways related to tryptophan metabolism, glycerophospholipid catabolism, bile acid biosynthesis, and fatty acid metabolism. The results suggest that SD treatment can effectively alleviate symptoms of RA and regulate metabolic disorders in CIA rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Tuba Recber, Emirhan Nemutlu, Kemal Beksac, Omer Cennet, Volkan Kaynaroglu, Sercan Aksoy, Sedef Kir
Summary: Early diagnosis and effective treatment are crucial for the survival of breast cancer patients. Metabolomic studies can aid in discovering new biomarkers, as shown in this study where a new method was developed to find early detection biomarkers from plasma. The study identified 35 metabolites significantly altered between healthy volunteers and breast cancer patients of different stages, suggesting their potential as biomarkers for early diagnosis.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemical Research Methods
Kirsten E. E. Overdahl, Justin B. B. Collier, Anton M. M. Jetten, Alan K. K. Jarmusch
Summary: Feature finding is a common method in processing untargeted mass spectrometry data to obtain a list of chemicals present in a sample. This study introduces signal response evaluation as a method to assess the individual features observed in untargeted MS data.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Food Science & Technology
Ziwei Wang, Lin Zhou, Wenqian Hao, Yu Liu, Xia Xiao, Xiao Shan, Chenning Zhang, Binbin Wei
Summary: This study compared the total phenolic content (TPC), total flavonoid content (TFC), and in vitro antioxidant activities of 21 batches of Chinese cherries, and established a method based on UPLC-QTOF/MS metabolomics and machine learning algorithms to distinguish the cherry species. The results showed that P. tomentosa had higher TPC and TFC, with average content differences of 12.07 times and 39.30 times, respectively, and exhibited better antioxidant activity. Various differential compounds were identified, including flavonoids, organooxygen compounds, and cinnamic acids and derivatives. Machine learning algorithms achieved high prediction accuracy, with support vector machine (SVM) at 85.7%, and random forest (RF) and back propagation neural network (BPNN) both at 100%.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Georgios A. Koulis, Aristeidis S. Tsagkaris, Reza Aalizadeh, Marilena E. Dasenaki, Eleni I. Panagopoulou, Spyros Drivelos, Michal Halagarda, Constantinos A. Georgiou, Charalampos Proestos, Nikolaos S. Thomaidis
Summary: This study utilized high-resolution mass spectrometry to analyze phenolic compounds in honey, identifying markers related to authenticity and geographical origin. Bioactive compounds in honey were revealed through suspect screening, with advanced chemometric tools used to identify markers related to honey geographical origin. The study had an impact on food authenticity and metabolomic fields by utilizing targeted and non-targeted workflows.
Article
Multidisciplinary Sciences
Sisi Cao, Lei Shi, Ying Shen, Luwen He, Xiangcai Meng
Summary: This study found that drought promotes the biosynthesis of secondary metabolites and the activity of antioxidant enzymes in Saposhnikovia divaricata, enhancing the plant's adaptability. The research also analyzed the metabolic pathways of S. divaricata in an arid environment.
Article
Biochemistry & Molecular Biology
Ruifeng Ji, Thomas Avery Garran, Yilu Luo, Meng Cheng, Mengyue Ren, Xiuteng Zhou
Summary: An integrated strategy of combining UPLC-QTOF-MS and chemometrics was developed to profile identification markers for differentiating five species of ginseng. This study is critical for ensuring the appropriate use of these ginseng species. A total of 38 robust biomarkers, mainly composed of saponins with small amounts of amino acids and fatty acids, were identified.
Article
Chemistry, Applied
Yuan Pan, Hui-Wen Gu, Yi Lv, Xiao-Li Yin, Ying Chen, Wanjun Long, Haiyan Fu, Yuanbin She
Summary: This study established an UPLC-QTOF-MS-based untargeted metabolomic approach to discriminate the geographical origins of Chinese red wines. Significant differences were observed between wine samples from different regions in China. The identified markers successfully discriminated external validation wine samples with a recognition rate of up to 96.7%.
Article
Chemistry, Multidisciplinary
Yuqiu Chen, Zhefeng Xu, Siying Gao, Tao Zhang, Changbao Chen
Summary: A valid and comprehensive evaluation method for assessing the quality of Saposhnikovia divaricata has been established based on HPLC fingerprint analysis combined with cluster analysis, principal component analysis, partial least square discriminant analysis, and similarity analysis. The fingerprint of S. divaricata was successfully established, and the similarity of the fingerprints of the samples was above 0.9. This method provides a scientific basis and reference for quality control and evaluation of S. divaricata.
JOURNAL OF CHEMISTRY
(2022)
Article
Food Science & Technology
Srikanth Ponneganti, Upadhyayula Suryanarayana Murty, Chandrakant Bagul, Roshan M. Borkar, P. Radhakrishnananda
Summary: In this study, the chemical profile of Phlogacanthus thyrsiformis leaf extracts was analyzed, and their antioxidant and enzyme inhibitory potential were evaluated. The results showed that the chloroform extract had the highest total phenolic content and antioxidant activity, while the ethyl acetate extract exhibited the highest enzyme inhibition potential.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Genetics & Heredity
Dongfeng Li, Yongfu Wu, Kai Shi, Minghui Shao, Ying Duan, Minli Yu, Chungang Feng
Summary: This study investigated the effects of rearing systems on bone quality parameters in chickens using a metabolomics strategy. The results showed that floor-reared chickens had higher bone density, ash content, calcium content, and phosphorus content compared to cage-reared chickens. Metabolomics analysis identified several metabolites and metabolic pathways associated with bone quality parameters.
FRONTIERS IN GENETICS
(2023)
Article
Chemistry, Multidisciplinary
Wafa A. Bawazir, Maymoona A. Al-Mahmood, Rawan S. Almalki, Ghadi F. Alofi, Raghad S. Alharbi, Zoya Zaheer
Summary: This study investigates the interaction between sulfathiazole and three types of surfactants using UV-visible spectroscopy and conductivity measurements. The results show that the critical micelle concentration of cationic and anionic surfactants decreases with increasing sulfathiazole concentration, while the interaction with non-ionic surfactant is weak.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Musaad K. Aleid, Khalid N. Alharbi, Mona A. Aljufareen, Areej S. Aloliwi, Alhanouf K. Almutairi, Rahaf S. Alsaif, Nada K. Alshayeb, Mohammed S. Almoiqli
Summary: This study assessed the levels of trihalomethane compounds in the water network of Riyadh city and identified the factors influencing their formation. The concentrations of trihalomethane compounds were within the permissible limits, indicating the water's safety for human consumption. The presence of bromide ions, organic carbon, free chlorine, and pH values were found to affect trihalomethane formation.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Said Arhzaf, Jamal Houssaini, Mohammed Naciri Bennani, Marwa Alaqarbeh, Mohammed Bouachrine
Summary: The study shows that Mg-Al hydrotalcite catalysts intercalated with acetate and carbonate anions exhibit superior catalytic activity in the aldol condensation reaction between furfural and acetone. The optimal reaction conditions are at 90 degrees C for 2 hours, achieving conversion rates of over 98% with high selectivity towards F2A for the acetate catalyst.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Uyen-Chi Nguyen Le, Ngoc Xuan Dat Mai, Kieu-Minh Le, Hoang Anh Vu, Huynh-Nhu Thi Tran, Tan Le Hoang Doan
Summary: This study aimed to enhance the bioavailability of rosmarinic acid, a bioactive compound with high anticancer activity, by encapsulating it in tetrasulfide-based porous organosilica nanoparticles. The synthesized nanoparticles were small in size and had a high surface area and an average pore diameter. The nanoparticles showed effective accumulation in cancer cells without toxicity to normal cells. Treatment with rosmarinic acid-containing nanoparticles resulted in significant cell death in cancer cells. Overall, these findings suggest that the synthesized nanoparticles can enhance the pharmacological effects of rosmarinic acid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jiamin Qi, Hengxi Zhu, Tianyu Yang, Xingyuan Wang, Zixuan Wang, Xiaoli Lei, Bin Li, Wenmin Qian
Summary: This study synthesized a novel iron-biochar adsorbent using the iron content in red mud to remove heavy metals from wastewater. The adsorbent showed excellent removal efficiency and sustainability. This method addresses both industrial waste recovery and heavy metal adsorption issues.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Bo Yi, Li Zhang, Haiyang Zhou
Summary: Plasma protein binding plays a crucial role in the pharmacokinetics and pharmacodynamics of therapeutic bioactive materials. In this study, the interaction of nordentatin, a member of coumarins, with human alpha-1 acid glycoprotein (AGP) was investigated, and the anticancer potency of nordentatin against human colorectal cancer cells was evaluated. The results showed that nordentatin binds to AGP through a static quenching mechanism and exhibits inhibitory effects on the growth of HCT-116 cells by increasing intracellular ROS and [Ca2+] levels and triggering apoptosis-related gene overexpression. Therefore, nordentatin could be a promising plant-based therapy for colorectal cancer.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qiming Pang, Cui Wang, Bangtao Li, Suli Zhang, Jiaoyang Li, Shuo Gu, Xueyu Shi
Summary: This study evaluated the effects of resveratrol loaded in copolymer nanoparticles on cerebral ischemia/reperfusion (I/R) injury in rats. The results showed that RES.CP.NPs could have neuroprotective effects through their antioxidant and anti-inflammatory activities, leading to improved neurological disability scores and decreased oxidative stress levels.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T. H. Wu, Hsu-Shan Huang
Summary: Tetraheterocyclic compounds derived from natural sources and contemporary pharmaceuticals have shown promise as multitarget therapeutic agents. In this study, a series of synthesized compounds were evaluated for their potential in breast cancer treatment. Compounds 18 and 20 demonstrated significant antiproliferative activity against breast cancer cell lines and their mode of action was revealed through molecular docking simulations.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Mohammad Khosravani, Mohsen Dehghani Ghanatghestani, Farid Moeinpour, Hossein Parvaresh
Summary: The aim of removing Pb(II) from water is to minimize the potential harm posed by toxic metals to both human health and the environment. A covalent organic framework adsorbent called TFPOTDB-SO3H was developed with excellent properties such as high repeatability, selectivity, and easy solid-liquid separation. The adsorbent showed impressive capability of adsorbing Pb(II) and effective removal of it from a solution with various ions, suggesting its potential for effectively adsorbing and removing Pb(II) heavy metal ions from wastewater.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Ashraf H. Farha, Mohamed S. Shams, Hasna A. Alali, Zakia H. Alhashem, Shehab A. Mansour, Shrouq H. Aleithan, Ragab A. Elsad
Summary: The current study examines the dielectric and thermal properties of transformer oil incorporated with Mn0.5 Zn0.5 Fe2O4 nanoparticles. The results show that the addition of Mn-Zn ferrite NPs improves the dielectric constant, dissipation factor, AC breakdown voltage, and convective heat transfer of the nanofluid.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Limin Hou, Zongpei Jiang, Minqi Ye, Xueyan Sun, Kexin Liu, Yifan Zhu, Xiaoyu Wang, Liangzhu Chen, Ruiheng Gu, Binghu Fang
Summary: The excessive accumulation of antibiotic residue in animal-derived foods poses a threat to health. Therefore, it is necessary to establish a rapid, simple, effective, safe, and highly sensitive method for detecting lincomycin residues. By using a pre-column derivatization method on high-performance liquid chromatography equipped with ultraviolet, the UV absorption of lincomycin is improved, allowing for detection and quantification.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Kun Tang, Xin-Xin Wang, Jin-Jin Zhao, Ning Ren, Jian-Jun Zhang
Summary: This study reports the synthesis, crystal structures, and thermal degradation properties of three new rare earth coordination compounds. Compounds 1-3 exhibit binuclear structures which can form chain-like structures via hydrogen bonding. Compound 2 shows potential application value in the orange-red luminescence region.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Seoyoun Yang, Eunbi Yu, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Su Bin Han, Soo Hyun Kang, Jung Hyun Lee, Heejun Ha, Minkyung Song, Jae Youl Cho, Jongsung Lee
Summary: This study investigated the effects of blue light on the hypodermis and found that it has antiadipogenic properties by reducing lipid accumulation and downregulating the expression of adipogenic genes. Blue light also increased the phosphorylation of PPAR gamma and TRPV1, suggesting its anti-adipogenic effect through these signaling pathways.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Abdul Nasir, Abdul Waheed Khan, Hamid Rafiq Khattak, Abdus Samad, Sami Ullah, Haroon Khan, Muhammad Faheem, Qian Bai
Summary: This study evaluated the effects of isoxazolone derivatives on cisplatin-induced neuropathy in a rat model. The results showed that isoxazolone derivatives effectively reversed mechanical allodynia, similar to the known therapeutic agent pregabalin. Molecular docking analysis indicated that isoxazolone derivatives have strong binding affinity for relevant receptors and potential inhibitory activity against relevant signaling pathways. This study has innovative implications for the treatment of cisplatin-induced neuropathic pain.
ARABIAN JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Shahid Wahab, Haroon Muhammad Ali, Maham Khan, Tariq Khan, Chandran Krishnaraj, Soon-Il Yun
Summary: In this study, we synthesized chitosan nanoparticles, silver nanoparticles, and chitosan/silver nanocomposites using aqueous ginger extract as a green approach. These nanomaterials showed significant antibacterial properties and low toxicity. Furthermore, the nanomaterials conjugated with tobramycin demonstrated enhanced antibacterial efficacy and exhibited interactions with Pseudomonas aeruginosa.
ARABIAN JOURNAL OF CHEMISTRY
(2024)