Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Modulation of brain function by targeted delivery of GABA through the disrupted blood-brain barrier

(2019) Nick Todd et al.   NEUROIMAGE

Rapid Short-pulse Ultrasound Delivers Drugs Uniformly across the Murine Blood-Brain Barrier with Negligible Disruption

(2019) Sophie V. Morse et al.   RADIOLOGY

Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters

(2019) Q. Zhong et al.   BIOMATERIALS

Ultrasonic modulation of neural circuit activity

(2018) William J Tyler et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuromodulation with transcranial focused ultrasound

(2018) Jan Kubanek   Neurosurgical Focus

Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

(2018) Nir Lipsman et al.   Nature Communications

Acoustically targeted chemogenetics for the non-invasive control of neural circuits

(2018) Jerzy O. Szablowski et al.   Nature Biomedical Engineering

Acoustic Transmission Factor through the Rat Skull as a Function of Body Mass, Frequency and Position

(2018) Matthieu Gerstenmayer et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Noninvasive Targeted Transcranial Neuromodulation via Focused Ultrasound Gated Drug Release from Nanoemulsions

(2017) Raag D. Airan et al.   NANO LETTERS

Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose

(2017) Dallan McMahon et al.   Theranostics

External triggering and triggered targeting strategies for drug delivery

(2017) Yanfei Wang et al.   Nature Reviews Materials

On being a circuit psychiatrist

(2016) Joshua A Gordon   NATURE NEUROSCIENCE

Spike sorting for large, dense electrode arrays

(2016) Cyrille Rossant et al.   NATURE NEUROSCIENCE

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

(2016) Zsofia I. Kovacs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The secondary Bjerknes force between two gas bubbles under dual-frequency acoustic excitation

(2016) Yuning Zhang et al.   ULTRASONICS SONOCHEMISTRY

Dynamic Behavior of Microbubbles during Long Ultrasound Tone-Burst Excitation: Mechanistic Insights into Ultrasound-Microbubble Mediated Therapeutics Using High-Speed Imaging and Cavitation Detection

(2016) Xucai Chen et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Safety Validation of Repeated Blood–Brain Barrier Disruption Using Focused Ultrasound

(2016) Thiele Kobus et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Behavioral alterations following blood-brain barrier disruption stimulated by focused ultrasound

(2016) Feng-Yi Yang et al.   Oncotarget

The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review

(2014) Gianluca Serafini et al.   Current Neuropharmacology

Noninvasive, neuron-specific gene therapy can be facilitated by focused ultrasound and recombinant adeno-associated virus

(2014) S Wang et al.   GENE THERAPY

Transcranial cavitation detection in primates during blood-brain barrier opening-a performance assessment study

(2014) Shih-Ying Wu et al.   IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL

Tactile frequency discrimination is enhanced by circumventing neocortical adaptation

(2014) Simon Musall et al.   NATURE NEUROSCIENCE

Neural Circuit Reprogramming: A New Paradigm for Treating Neuropsychiatric Disease?

(2014) Kay M. Tye   NEURON

Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound

(2013) Po-Hung Hsu et al.   PLoS One

Rat whisker motor cortex is subdivided into sensory-input and motor-output areas

(2013) Jared B. Smith et al.   Frontiers in Neural Circuits

Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening

(2013) Angelika Alonso et al.   Molecular Therapy-Nucleic Acids

Active Emergence from Propofol General Anesthesia Is Induced by Methylphenidate

(2012) Jessica J. Chemali et al.   ANESTHESIOLOGY

Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

(2012) James W. Murrough et al.   BIOLOGICAL PSYCHIATRY

Analysis of ibotenic acid and muscimol in Amanita mushrooms by hydrophilic interaction liquid chromatography–tandem mass spectrometry

(2012) Kunio Gonmori et al.   Forensic Toxicology

Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound

(2012) Emmanuel Thévenot et al.   HUMAN GENE THERAPY

Adverse effects of antiepileptic drugs

(2012) Piero Perucca et al.   LANCET NEUROLOGY

Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring

(2012) Costas D. Arvanitis et al.   PLoS One

A review of low-intensity focused ultrasound pulsation

(2011) Alexander Bystritsky et al.   Brain Stimulation

Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery

(2011) Bart Geers et al.   JOURNAL OF CONTROLLED RELEASE

Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors

(2011) Shashank R. Sirsi et al.   JOURNAL OF CONTROLLED RELEASE

Capacitive micromachined ultrasonic transducers for medical imaging and therapy

(2011) Butrus T Khuri-Yakub et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Metabolic and cardiovascular adverse effects associated with antipsychotic drugs

(2011) Marc De Hert et al.   Nature Reviews Endocrinology

Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex

(2011) Tianyi Mao et al.   NEURON

Microinjection of Propofol into the Perifornical Area Induces Sedation with Decreasing Cortical Acetylcholine Release in Rats

(2010) Sanae Gamou et al.   ANESTHESIA AND ANALGESIA

RBC velocities in single capillaries of mouse and rat brains are the same, despite 10-fold difference in body size

(2010) Miyuki Unekawa et al.   BRAIN RESEARCH

Ultrasound-triggered release of materials entrapped in microbubble–liposome constructs: A tool for targeted drug delivery

(2010) Alexander L. Klibanov et al.   JOURNAL OF CONTROLLED RELEASE

Multi-Modality Safety Assessment of Blood-Brain Barrier Opening Using Focused Ultrasound and Definity Microbubbles: A Short-Term Study

(2010) Babak Baseri et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

MI Neuronal Responses to Peripheral Whisker Stimulation: Relationship to Neuronal Activity in SI Barrels and Septa

(2008) Shubhodeep Chakrabarti et al.   JOURNAL OF NEUROPHYSIOLOGY

Imaging the spread of reversible brain inactivations using fluorescent muscimol

(2008) Timothy A. Allen et al.   JOURNAL OF NEUROSCIENCE METHODS