DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR

Selective degradation of IKKα by autophagy is essential for arsenite-induced cancer cell apoptosis

(2020) Qixing Tan et al.   Cell Death & Disease

Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages

(2020) Rui Zhang et al.   Cell Death & Disease

Efficacy and safety of osimertinib in treating EGFR-mutated advanced NSCLC: A meta-analysis

(2019) Lilan Yi et al.   INTERNATIONAL JOURNAL OF CANCER

Corrigendum to increased expression of DRAM1 confers myocardial protection against ischemia via restoring autophagy flux [J Mol Cell Cardiol. 2018 Nov;124:70–82]

(2019) Xiaoqian Wu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle

(2019) Ji Geng et al.   FASEB JOURNAL

DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway

(2019) Ting Lu et al.   Cell Communication and Signaling

DRAM1 deficiency affects the organization and function of the Golgi apparatus

(2019) Mingzhen Wei et al.   CELLULAR SIGNALLING

mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

(2019) Florian Beaumatin et al.   MOLECULAR CELL

TSG101 interacts with the androgen receptor and attenuates its expression through the endosome/lysosome pathway

(2018) Yen-Ming Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The exon 19-deleted EGFR undergoes ubiquitylation-mediated endocytic degradation via dynamin activity-dependent and -independent mechanisms

(2018) Taishu Wang et al.   Cell Communication and Signaling

Precision oncology in non-small-cell lung cancer: opportunities and challenges

(2018) Chul Kim et al.   Nature Reviews Clinical Oncology

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

(2018) Huanbin Wang et al.   Nature Chemical Biology

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

(2017) Haiyang Zhang et al.   Nature Communications

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

An improved smaller biotin ligase for BioID proximity labeling

(2016) Dae In Kim et al.   MOLECULAR BIOLOGY OF THE CELL

CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediated degradation of EGFR

(2016) J Hou et al.   ONCOGENE

Radiation induces autophagic cell death via the p53/DRAM signaling pathway in breast cancer cells

(2016) LI CUI et al.   ONCOLOGY REPORTS

LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation

(2015) X. Tan et al.   EMBO JOURNAL

Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M

(2015) Kenneth S Thress et al.   NATURE MEDICINE

TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells

(2015) F Lozupone et al.   ONCOGENE

DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX

(2015) J-J Guan et al.   Cell Death & Disease

The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense

(2014) Michiel van der Vaart et al.   Cell Host & Microbe

DRAM1 Protects Neuroblastoma Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Injury via Autophagy

(2014) Mengqiang Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria

(2014) K Liu et al.   Cell Death & Disease

PHD3 regulates EGFR internalization and signalling in tumours

(2014) Boyan K. Garvalov et al.   Nature Communications

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DRAM1 Regulates Autophagy Flux through Lysosomes

(2013) Xing-Ding Zhang et al.   PLoS One

DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4+ T Cells Infected with HIV

(2013) Mireille Laforge et al.   PLoS Pathogens

Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition

(2012) Xiaolei Xie et al.   Autophagy

DRAM-1 encodes multiple isoforms that regulate autophagy

(2012) Li Yen Mah et al.   Autophagy

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

(2012) Julian R. Molina et al.   MAYO CLINIC PROCEEDINGS

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

(2012) S Galavotti et al.   ONCOGENE

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum

(2009) Xing-Ding Zhang et al.   Autophagy

Aberrant trafficking of NSCLC-associated EGFR mutants through the endocytic recycling pathway promotes interaction with Src@

(2009) Byung Chung et al.   BMC CELL BIOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Differential Effects of EGFR Ligands on Endocytic Sorting of the Receptor

(2009) Kirstine Roepstorff et al.   TRAFFIC

LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII

(2008) M A Stutz et al.   ONCOGENE