Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance

Targeting BCL-2 proteins in pediatric cancer: Dual inhibition of BCL-XL and MCL-1 leads to rapid induction of intrinsic apoptosis

(2020) Sarah Kehr et al.   CANCER LETTERS

Recent advances in the development of Mcl-1 inhibitors for cancer therapy

(2019) Alexander W. Hird et al.   PHARMACOLOGY & THERAPEUTICS

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies

(2019) Joan Montero et al.   Nature Communications

Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells

(2018) Michael Torsten Meister et al.   CANCER LETTERS

BCL-x L -selective BH3 mimetic sensitizes rhabdomyosarcoma cells to chemotherapeutics by activation of the mitochondrial pathway of apoptosis

(2018) Sara Fatima Faqar-Uz-Zaman et al.   CANCER LETTERS

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins

(2018) Colin Hockings et al.   CELL DEATH AND DIFFERENTIATION

Accelerating drug development in pediatric cancer: a novel Phase I study design of venetoclax in relapsed/refractory malignancies

(2018) Andrew E Place et al.   Future Oncology

BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis

(2018) Ulrike Heinicke et al.   ONCOGENE

A review of soft-tissue sarcomas: translation of biological advances into treatment measures

(2018) Ngoc T Hoang et al.   Cancer Management and Research

Bruton’s tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia

(2017) J Deng et al.   LEUKEMIA

iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry

(2016) Jeremy Ryan et al.   BIOLOGICAL CHEMISTRY

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

(2016) Elizabeth C. Townsend et al.   CANCER CELL

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models

(2016) András Kotschy et al.   NATURE

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax

(2016) Joan Montero et al.   Cancer Discovery

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

(2016) Monica Pallis et al.   Oncotarget

Improving the outcome for children with cancer: Development of targeted new agents

(2015) Peter C. Adamson   CA-A CANCER JOURNAL FOR CLINICIANS

Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia

(2015) Shuo-Chieh Wu et al.   CANCER CELL

Drug-Induced Death Signaling Strategy Rapidly Predicts Cancer Response to Chemotherapy

(2015) Joan Montero et al.   CELL

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

(2015) Joel D. Leverson et al.   Science Translational Medicine

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin

(2015) Zuzanna Baranski et al.   Oncotarget

Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

(2014) Glenna Wink Foight et al.   ACS Chemical Biology

What is new in the biology and treatment of pediatric rhabdomyosarcoma?

(2013) Douglas S. Hawkins et al.   CURRENT OPINION IN PEDIATRICS

Pan-Mammalian Target of Rapamycin (mTOR) Inhibitor AZD8055 Primes Rhabdomyosarcoma Cells for ABT-737-induced Apoptosis by Down-regulating Mcl-1 Protein

(2013) Ellen Preuss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

Bcl2 family proteins in carcinogenesis and the treatment of cancer

(2009) Anna Frenzel et al.   APOPTOSIS

Molecular and cellular biology of rhabdomyosarcoma

(2009) Carla De Giovanni et al.   Future Oncology

Control of mitochondrial apoptosis by the Bcl-2 family

(2009) J. K. Brunelle et al.   JOURNAL OF CELL SCIENCE