Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 73, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2020.104090
Keywords
Resveratrol; Adiponectin receptor; Myosin heavy chain; Skeletal muscle; PGC-1 alpha; Pig
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Funding
- National Natural Science Foundation of China [31460606, 31760672]
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This study explored molecular mechanisms of resveratrol (RES) on regulating skeletal fiber-type switching in pigs. RES had no effect on growth performance of pigs. Remarkably, myosin heavy chain (MyHC)1 and MyHC2a mRNA level were increased, while MyHC2b decreasing in Longissimus thoracis (LT) after RES treatment. Meanwhile, RES increased enzyme activities including Succinate Dehydrogenase (SDH) and Malate Dehydrogenase (MDH) in LT. Moreover, RES upregulated the plasma AdipoQ concentration, the expression of AdipoQ, Adiponectin receptor 1(AdipoR1), AdipoR2, AMPK and PGC-1 alpha in AdipoQ signaling pathway in pigs. In addition, RES treating the porcine skeletal muscle satellite cells results showed that RES increased the expression of AdipoR1, AMPK, PGC-1a alpha, MyHC1 and MyHC2a, while decreasing MyHC2b expression. Although RES was added into cells, the AMPK and PGC-1 alpha expression could not be increased by knockdown of AdipoR1 expression. This study demonstrated that RES increased the proportion of oxidative muscle fiber through the AdipoR1-AMPK-PGC-1 alpha pathway in pigs.
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