Article
Nutrition & Dietetics
Meng-Meng Niu, Huan-Xin Guo, Jun-Wu Cai, Xiang-Chen Meng
Summary: This study explores the intestinal barrier repair mechanisms of Bifidobacterium breve (B. breve) strains H4-2 and H9-3 with different exopolysaccharide (EPS) production in mice with colitis. The results demonstrate that both strains of B. breve can regulate cytokine levels and repair intestinal damage caused by colitis. H4-2, with higher EPS output, is more effective at repair than H9-3. These findings are important for clinical applications and the development of probiotic products for colitis treatment.
Article
Nutrition & Dietetics
Hui Wang, Xinyuan Zhang, Xinfang Kou, Zhengyuan Zhai, Yanling Hao
Summary: This study found that the EPS-producing strain Bifidobacterium pseudocatenulatum Bi-OTA128 has significant anti-inflammatory effects on DSS-induced colitis. It improves colitis symptoms, maintains intestinal barrier integrity, reduces oxidative stress and inflammatory responses, and regulates gut dysbiosis.
Article
Agriculture, Multidisciplinary
Cheng Wan, Wen-Wen Qian, Wei Liu, Xionge Pi, Meng-Ting Tang, Xiao-Lin Wang, Qing Gu, Ping Li, Tao Zhou
Summary: The study found that EPS produced by L. rhamnosus ZFM231 significantly improved the symptoms of mice with inflammatory bowel disease, including weight loss, colonic tissue damage, and disease activity index score. The EPS treatment also effectively modulated the gut microbiota composition and increased the levels of short-chain fatty acids and anti-inflammatory factors in colonic cells.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Nutrition & Dietetics
Sen Li, Lei Luo, Shuo Wang, Qiqi Sun, Yu Zhang, Kai Huang, Xiao Guan
Summary: This study investigated the regulation of vitexin on colitis by evaluating its effects on gut microbiota and intestinal inflammation using in vitro and in vivo models. The results showed that vitexin could alter the gut microbiota structure, down-regulate the expression of inflammatory factors, and improve intestinal barrier function, leading to alleviation of colitis symptoms.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Ida Sogaard Larsen, Benjamin A. H. Jensen, Erica Bonazzi, Beatrice S. Y. Choi, Nanna Ny Kristensen, Esben Gjerloff Wedebye Schmidt, Annika Sueenderhauf, Laurence Morin, Peter Bjarke Olsen, Lea Benedicte Skov Hansen, Torsten Schroeder, Christian Sina, Benoit Chassaing, Andre Marette
Summary: Through oral administration of lysozyme derived from Acremonium alcalophilum, bowel function in diet-induced obesity and chemically induced colitis can be improved. Lysozyme dose-dependently alleviates intestinal inflammation in colitis-challenged mice, protects against microbiota encroachment and fasting hyperinsulinemia in obese mice. This indicates that lysozyme leverages the gut microbiota to enhance gut health and combat inflammation.
Article
Biochemistry & Molecular Biology
Ui-Jin Bae, Ha-Na Jang, Sung-Hyen Lee, Ji-Young Kim, Gi-Chang Kim
Summary: The study investigated the anti-inflammatory and antioxidant effects of Oenanthe javanica ethanol extract (OJE) in mice with DSS-induced colitis. Results showed that OJE treatment reduced inflammation, protected the colon, and modulated gut microbial composition, suggesting potential benefits for colitis treatment.
Article
Food Science & Technology
Chen Wang, Junying Bai, Botao Wang, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Huayi Suo, Wei Chen, Qixiao Zhai
Summary: The prebiotic stachyose, extracted from plants, has been found to alleviate intestinal inflammation by regulating gut microbiota. Its administration can restore body weight, protect against colonic tissue damage, reduce pro-inflammatory cytokines levels, and reverse histological abnormalities in ulcerative colitis mice. Furthermore, stachyose can restore disturbed intestinal bacteria and alter serum metabolites against inflammatory responses in colitis mice. These findings provide a strong foundation for future studies on the protective role of stachyose in maintaining intestinal homeostasis.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Kwang-Youn Kim, Jae Dong Son, Su-Jin Hwang, Jong Kwang Lee, Jae Young Park, Kwang Il Park, Tae Woo Oh
Summary: Fermented glutinous rice can improve ulcerative colitis by regulating the expression of tight junction proteins, reducing inflammation, and inhibiting apoptosis. The treatment with fermented glutinous rice can protect the intestinal barrier function, suppress inflammation, and prevent apoptosis, making it a potential candidate for treating and preventing inflammatory bowel disease.
Article
Food Science & Technology
Pengxiang Xu, Shuwei Luo, Jiangfeng Song, Zhuqing Dai, Dajing Li, Cai'e Wu
Summary: This study constructed a sodium alginate hydrogel-based delivery system loaded with lutein nanoparticles for the treatment of colitis. The results showed that the lutein hydrogel effectively alleviated colitis symptoms by reducing colon tissue damage, inflammatory factor levels, and adjusting fecal heme content. The hydrogel also improved the integrity of the intestinal barrier, inhibited the NF-KB pathway, and modulated the expression and secretion of inflammatory factors. Additionally, it positively influenced the intestinal microbial environment. The sodium alginate-based hydrogel shows promising prospects as a slow-release carrier for lutein nanoparticles.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Yiren Yang, Yuwei Zhang, Jiangping Song, Yaqian Li, Liuyang Zhou, Hongtao Xu, Kaizhang Wu, Jie Gao, Mouming Zhao, Yang Zheng
Summary: This study found that polysaccharides from bergamot (BP) can alleviate colitis symptoms by regulating gut microbiota and metabolism. The results showed that BP can promote the proliferation of beneficial bacteria, increase the levels of short-chain fatty acids and L-phenylalanine, and reduce inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Gastroenterology & Hepatology
Xiaomeng You, Asha Rani, Ezgi Ozcan, Yang Lyu, David A. Sela
Summary: Human milk shapes the microbiota in the infant gut, and urea in milk may serve as a nitrogen source for the microbiota. Bifidobacterium infantis strains are capable of utilizing urea nitrogen and play a role in infant nutrition and development. Isotopically labeled urea nitrogen can be incorporated into microbial products for infant host utilization.
Article
Immunology
Yongzhi Hua, Ruiqi Liu, Min Lu, Xueneng Guan, Suyang Zhuang, Yaozhou Tian, Zhenhai Zhang, Li Cui
Summary: Juglone has been found to have therapeutic effects on ulcerative colitis in mice, modulating gut microbiota and restoring Th17/Treg balance. The results show that juglone can alleviate UC symptoms, reduce inflammatory protein levels, and impact gut microbiota and Th17/Treg ratio.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Microbiology
Namrata Iyer, Michelle A. Williams, Amy A. O'Callaghan, Elaine Dempsey, Raul Cabrera-Rubio, Mathilde Raverdeau, Fiona Crispie, Paul D. Cotter, Sinead C. Corr
Summary: This study confirms the probiotic potential of Lactobacillus salivarius UCC118 (TM) in the treatment of inflammatory bowel disease. The strain can promote health by upregulating the expression of the anti-inflammatory cytokine IL-10 and improving dysbiosis associated with the microbiome.
Article
Biochemistry & Molecular Biology
Zewen Mei, Xingxi Huang, Heng Zhang, Danyi Cheng, Xin Xu, Mingyue Fang, Jutuan Hu, Yangyang Liu, Yunxiang Liang, Yuxia Mei
Summary: Chitin derivatives have a therapeutic effect in ulcerative colitis mice model by relieving inflammation symptoms, protecting the colon, and increasing the abundance of gut microbiota and concentrations of short-chain fatty acids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Hao Nie, Yingli Li, Xiao-Ling Lu, Jing Yan, Xiang-Ru Liu, Qi Yin
Summary: This study found that prodigiosin derived from a chromium-resistant Serratia sp. can modulate the gut microbiota and inflammatory response, thereby improving symptoms of ulcerative colitis (UC) mice model. Prodigiosin improves DSS-induced dysbiosis by restoring the abundance of Bacteroidota and prevents the reduction of colonic length and DSS-induced mortality. It also suppresses the expression of inflammatory factors and accelerates the expression of intestinal tight junction proteins, effectively preventing inflammatory response and protecting intestinal barrier integrity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amel Sami, Imad Elimairi, C. Anthony Ryan, R. Paul Ross, Catherine Stanton
Summary: This study investigates the impact of the smokeless tobacco product Toombak on the body's cortisol response and analyzes the psycho-dependency level of Toombak users. The results show that Toombak users have significantly lower hair cortisol levels compared to non-users, and they exhibit high levels of psycho-dependency and nicotine tolerance.
Article
Biochemistry & Molecular Biology
Mingjie Li, Jiuhong Ding, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Bo Yang, Wei Chen
Summary: In this study, it was found that B. longum subsp. infantis FJSYZ1M3 could alleviate DSS-induced colitis through various mechanisms, including maintaining the intestinal barrier, regulating inflammatory cytokines, and modifying the gut microbiota.
Article
Gastroenterology & Hepatology
Colin Buttimer, Ekaterina V. Khokhlova, Lisa Stein, Cara M. Hueston, Bianca Govi, Lorraine A. Draper, R. Paul Ross, Andrey N. Shkoporov, Colin Hill
Summary: This study isolates and characterizes six bacteriophages that can infect Ruminococcus gnavus, a gut microbe associated with inflammatory bowel disease. The phages have a temperate lifestyle and can coexist with the host bacterium without causing a significant reduction in its abundance. Analysis of gut virome data reveals a high abundance of these phages in individuals with IBD. This work provides insight into the interaction between phages and R. gnavus in the human gut microbiome.
Review
Gastroenterology & Hepatology
Susan Mills, Bo Yang, Graeme J. Smith, Catherine Stanton, R. Paul Ross
Summary: The colonization of Bifidobacterium in the neonatal gut highlights its significance to human health. Bifidobacterium longum is the most abundant species during early stages, but its levels decrease with age and in certain diseases. Research has revealed that B. longum produces bioactive molecules and can impact immune responses in various parts of the body. This review emphasizes the biological and clinical impacts of B. longum throughout different stages of human life, suggesting the need for further research and clinical trials to explore its potential in treating and preventing diseases.
Article
Microbiology
Ivan Sugrue, Daragh Hill, Paula M. O'Connor, Li Day, Catherine Stanton, Colin Hill, R. Paul Ross
Summary: This study describes a new variant of nisin, nisin E, produced by Streptococcus equinus strains isolated from sheep milk. The genome sequencing and analysis revealed similarities to nisin U, but with a unique rearrangement of the core peptide encoding gene. Nisin E showed antimicrobial activity against Lactobacillus, Bacillus, and Clostridiodes, and was immune to nisin U. The discovery of nisin E suggests its central role in the competitive nature of S. equinus.
Review
Food Science & Technology
Eleni Kamilari, Catherine Stanton, F. Jerry Reen, R. Paul Ross
Summary: This review highlights the biotechnological importance of the filamentous yeast-like fungus Geotrichum candidum, which is widely used as a starter in the dairy industry. The study found that aside from its role in the dairy and brewing industries, G. candidum has potential as a probiotic nutritional supplement in fish. Additionally, this species produces various biotechnologically important enzymes, antimicrobial compounds, and has bioremediation capabilities.
Article
Pediatrics
David B. Healy, Benjamin Campbell-Green, Vicki Livingstone, C. Anthony Ryan, R. Paul Ross, Catherine Stanton, Eugene M. Dempsey
Summary: The aim of this study was to evaluate the combined outcome of death and/or severe grade necrotising enterocolitis (NEC) in very preterm infants before and after the introduction of routine supplementation with Bifidobacterium bifidum and Lactobacillus acidophilus probiotics. The results showed a reduction in the composite outcome of severe grade NEC and/or death after the introduction of routine administration of probiotics.
Article
Agriculture, Multidisciplinary
Bowen Li, Mengfan Ding, Chi Chen, Jianxin Zhao, Guoxun Shi, Paul Ross, Catherine Stanton, Wei Chen, Bo Yang
Summary: The study demonstrates that Bifidobacterium longum subsp. infantis B6MNI can modulate the gut microbiota and fecal metabolites, impacting the progression of rheumatoid arthritis (RA) and delaying the disease.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Shona Uniacke-Lowe, Fergus W. J. Collins, Colin Hill, R. Paul Ross
Summary: With the increase in antimicrobial resistance, the deep-sea fish microbiome can serve as a potential source of antimicrobials, including bacteriocins. In this study, bacterial isolates recovered from deep-sea fish were screened for antimicrobial activity and their genomic DNA was analyzed for bacteriocin and other antimicrobial metabolite genes. The study identified 147 candidate biosynthetic gene clusters, including 35 bacteriocin clusters, and discovered unique bacteriocin gene clusters encoding novel peptides. This dual approach provided insights into the bacteriocinogenic potential and antimicrobial molecules of the deep-sea isolates.
Review
Gastroenterology & Hepatology
Lauren Walsh, Colin Hill, R. Paul Ross
Summary: This review focuses on the potential effect of glyphosate exposure on the composition and functionality of the gut microbiome, highlighting the significance of gut microbiota to health.
Review
Microbiology
Des Field, Miguel Fernandez de Ullivarri, R. Paul Ross, Colin Hill
Summary: Nisin, a highly post-translationally modified peptide, has been extensively studied over the past 100 years. While it has been used successfully as a food preservative, its potent activity against multidrug resistant microbes and potential for therapeutic use in treating bacterial infections has shifted the focus of research towards its biomedical applications. Recent developments have shed light on the biosynthesis, cellular location, and genetic regulation of nisin, and there is growing interest in its potential role in influencing the microbiome and in bioengineering novel variants for biomedical applications.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Nutrition & Dietetics
Xinqi Chen, Yang Chen, Catherine Stanton, Reynolds Paul Ross, Jianxin Zhao, Wei Chen, Bo Yang
Summary: This study aimed to investigate the dose-response effect of Bifidobacterium breve CCFM683 on relieving psoriasis and its underlying patterns. Specifically, the expression of keratin 16, keratin 17, and involucrin were substantially decreased by specific doses of the probiotic. Moreover, the gut microbiota in mice treated with the probiotic was rebalanced and the concentrations of colonic bile acids were positively correlated with the effectiveness of the strain in relieving psoriasis.
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)
Article
Food Science & Technology
Kexue Chen, Xingya Zhou, Jianxin Zhao, R. Paul Ross, Catherine Stanton, Wei Chen, Bo Yang
Summary: This study explores the genetic diversity and functional gene features of L. johnsonii through comparative genomic analysis. The results show that L. johnsonii can be classified into two phylogenetic clusters, with differences in carbohydrate utilization genes, bacteriocin operon, extracellular polysaccharide gene cluster, and bile salt hydrolase encoding genes between the clusters.
Article
Food Science & Technology
Chi Chen, Yue Yue, Zhujun He, Bowen Li, Jianxin Zhao, Wei Chen, Bo Yang
Summary: This study compared the effects of five strains of Lactobacillus gasseri on ETEC-induced diarrhea and investigated their mechanisms. The results showed that three strains of L. gasseri could alleviate diarrhea by reducing inflammatory factors, normalizing gut microbiota, and producing short-chain fatty acids (SCFAs).
