Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2020.554548
Keywords
UPR; autophagy; synapse; neuropsychiatric disease; drug
Categories
Funding
- Academy of Finland
- Finska Lakaresallskapet
- Magnus Ehrnrooth Foundation
- Liv and Halsa Foundation
- Parkinson Foundation Finland
- Minerva Foundation
- EU H2020-MSCA-RISE-2016 [73479]
- Swedish Research Council [201802623, 2019-05820]
- Region Ostergotland [LIO-795611, LIO897641]
- Region South-East Sweden [FORSS-807001, FORSS-849051]
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Neurons are polarized in structure with a cytoplasmic compartment extending into dendrites and a long axon that terminates at the synapse. The high level of compartmentalization imposes specific challenges for protein quality control in neurons making them vulnerable to disturbances that may lead to neurological dysfunctions including neuropsychiatric diseases. Synapse and dendrites undergo structural modulations regulated by neuronal activity involve key proteins requiring strict control of their turnover rates and degradation pathways. Recent advances in the study of the unfolded protein response (UPR) and autophagy processes have brought novel insights into the specific roles of these processes in neuronal physiology and synaptic signaling. In this review, we highlight recent data and concepts about UPR and autophagy in neuropsychiatric disorders and synaptic plasticity including a brief outline of possible therapeutic approaches to influence UPR and autophagy signaling in these diseases.
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