Review
Pharmacology & Pharmacy
Xuejian Wang, Wenyan Jiang, Yanmei Du, Dongqi Zhu, Jian Zhang, Chunyan Fang, Fang Yan, Zhe-Sheng Chen
Summary: This review article summarizes the treatments and combination therapies that induce feedback activation of AKT, ERK, STAT3, EGFR, FGFR, and HER2/3 signaling pathways to enhance anti-tumor effect or overcome drug resistance. The underlying mechanisms of protein molecules involved in the feedback activation are explored. Clinical trials employing combination treatments to suppress feedback activation and improve therapeutic efficacy of cancer treatments are also reviewed.
DRUG RESISTANCE UPDATES
(2022)
Review
Biochemistry & Molecular Biology
Hee-Suk Chae, Seong-Tshool Hong
Summary: Despite progress in cancer treatment, conquering the disease remains a challenge. Cancer cells reprogram their metabolism to fuel their growth and survival, even in nutrient-poor environments. Metabolic alterations, such as increased glucose uptake and glycolysis, contribute to the unique features of cancer metabolism. High glutamine dependency and oncogenic signaling pathways also play important roles. Identifying convergent metabolic phenotypes is crucial for targeting cancer cells, and recent developments in anti-cancer therapy aim to exploit these metabolic vulnerabilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nora Dieguez-Martinez, Sergio Espinosa-Gil, Guillermo Yoldi, Elisabet Megias-Roda, Idoia Bolinaga-Ayala, Maria Vinas-Casas, Gokhan Gorgisen, Ines Domingo-Orti, Hector Perez-Montoyo, Jose R. Bayascas, Eva Colas, Xavier Dolcet, Jose M. Lizcano
Summary: Endometrial cancer is the most common gynecologic cancer in developed countries, and its overall survival rate is poor. This study suggests that inhibiting the ERK5/NF-kB pathway can suppress cell proliferation and survival in endometrial cancer and enhance the efficacy of chemotherapy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Md Ataur Rahman, Moon Nyeo Park, Md Hasanur Rahman, Md Mamunur Rashid, Rokibul Islam, Md Jamal Uddin, Md Abdul Hannan, Bonglee Kim
Summary: p53, the key tumor suppressor protein, plays a significant role in regulating various biological processes, including energy metabolism, cell cycle, apoptosis, and more. Autophagy, a crucial cellular process, is involved in maintaining cellular homeostasis. The relationship between p53 and autophagy is complex and not completely understood, as p53 can both inhibit and activate autophagy depending on its cellular localization and mode of action. Understanding the interaction between p53 and autophagy is important for cancer treatment and management.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Mary Luz Uribe, Ilaria Marrocco, Yosef Yarden
Summary: Growth factors like epidermal growth factor (EGF) can promote cell division and migration, but cancer hijacks these mechanisms for tumor growth and metastasis. Over-production and mutations of EGF and EGFR are common in various cancers, making them popular targets for anti-cancer therapies. The activation of EGFR triggers a series of molecular switches controlling gene expression, with implications for drug resistance and metastasis.
Article
Biochemistry & Molecular Biology
Ye Ji Shin, Jae Won Yun, Hong Sook Kim
Summary: This study analyzed key signaling pathways in ETV4-fusion-positive prostate cancer and proposed therapeutic targets and potential drugs.
Review
Oncology
Zhuo Wang, Tingting Zhao, Shihui Zhang, Junkai Wang, Yunyun Chen, Hongzhou Zhao, Yaxin Yang, Songlin Shi, Qiang Chen, Kuancan Liu
Summary: Wnt signaling plays important roles in tissue development, homeostasis maintenance, tumorigenesis, and cancer progression. Abnormal expression of signaling components is associated with tumor progression and poor prognosis, and the pathway also influences the tumor microenvironment and immune response. Drugs targeting the Wnt pathway offer multiple therapeutic values.
BIOMARKER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Haoyi Jin, Xi Liu, Hong-xu Liu
Summary: This article discusses the research progress on the regulatory roles and clinical applications of mannose in cancer. Mannose has direct anticancer effects and enhances the effectiveness of current cancer treatments. Recent studies have also reported its application as a biomarker for cancer or in the delivery of anticancer drugs.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Pharmacology & Pharmacy
Catherine Passirani, Anne Vessieres, Giuseppe La Regina, Wolfgang Link, Romano Silvestri
Summary: Identifying and validating proteins involved in resistance mechanisms is crucial for innovative therapeutic strategies to improve the clinical outcome of cancer patients. Rational treatment strategies targeting transcription factors, pseudokinases, nuclear export receptors, and immunogenic cell death show promise in overcoming therapy resistance. The success in inhibiting specific proteins and pathways implicated in drug resistance illustrates the potential of targeted therapies and immunotherapies to improve clinical outcomes.
DRUG RESISTANCE UPDATES
(2022)
Article
Public, Environmental & Occupational Health
Kexin Ling, Huli Qin, Yiman Feng, Hongxi Che, Jinxi Ding, Wei Li
Summary: This study aims to assess the association between different clinical trial endpoints and reimbursement decisions in China. The results show that PFS and ORR as primary endpoints are more likely to receive positive reimbursement decisions, and the clinical trial phase is also related to reimbursement decisions.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Oncology
Alvaro H. Ingles Garces, Nuria Porta, Trevor A. Graham, Udai Banerji
Summary: The evolution of drug-resistant cell subpopulations leads to treatment failure in cancer. Preclinical evidence suggests the possibility of influencing the response to subsequent treatments by modeling clonal evolution and collateral sensitivity. New therapy strategies and clinical trial designs are needed to steer cancer evolution. The competition between different subsets of drug-sensitive and resistant clones for nutrients/blood supply indicates the potential use of treatment paradigms based on cell-cell competition. This requires different clinical trial designs from the conventional practice and the integration of next-generation sequencing to improve the assessment of clinical response/resistance and exploit evolution.
CANCER TREATMENT REVIEWS
(2023)
Article
Health Care Sciences & Services
Jongsu Kim, Kyung Won Hwang, Hye Jung Lee, Hong Sook Kim
Summary: This study identified cellular signaling pathways associated with S:E fusion-positive prostate cancer and suggested potential therapeutic targets through gene-drug network analysis. Focal adhesion kinase (FAK)/PI3K-Akt signaling and JAK-STAT signaling were significantly enriched in S:E fusion-positive prostate cancer. PDGFRA and PDGFRB were the most frequently predicted therapeutic targets, with imatinib targeting both genes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Maria Grazia Cerrito, Emanuela Grassilli
Summary: The development of high-throughput approaches has enabled the identification of novel actionable targets for colorectal cancer treatment and the development of specific inhibitors, leading to treatment innovations such as re-sensitizing drug-resistant tumors in combination with chemotherapy and inducing synthetic lethality in tumors with specific oncogenic mutations.
Review
Biochemistry & Molecular Biology
Mengshu You, Zhuolin Xie, Nan Zhang, Yixuan Zhang, Desheng Xiao, Shuang Liu, Wei Zhuang, Lili Li, Yongguang Tao
Summary: A wide range of metabolites can be detected by specific sensors, which then activate signal transduction pathways and regulate gene expression in epigenetics, known as metabolite sensing. Metabolite sensing plays a crucial role in regulating metabolism, immunity, and inflammation, allowing the host to achieve a balance with the external environment. In cancer, metabolic reprogramming leads to phenotypic changes in cancer cells, including cell proliferation, migration, invasion, and angiogenesis, creating a microenvironment favorable for cancer growth. This article discusses the mechanisms of metabolite sensing for the three major nutrients and their derivatives, as well as their abnormalities in cancer development, and explores potential therapeutic targets based on metabolite-sensing signaling pathways to prevent cancer progression.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Pharmacology & Pharmacy
Maryam Nakhjavani, Rasika M. Samarasinghe, Sarah Shigdar
Summary: The key challenges in treating triple-negative breast cancer brain metastasis (TNBC-BM) lie in the absence of targeted therapy and difficulties in delivering drugs to the brain. This review introduces current drugs based on their molecular targets and seeks to improve drug delivery to the brain using more efficient and promising drug delivery systems. Ongoing clinical trials on druggable targets in TNBC-BM are described to achieve more targeted treatment, along with an introduction to the obstacles hindering drug delivery to the brain and strategies for future advancements in TNBC-BM patient treatment.
DRUG DISCOVERY TODAY
(2022)
Article
Oncology
Mikko O. Laukkanen, Maria Domenica Castellone
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2016)
Article
Oncology
Juha P. Laurila, Mikko O. Laukkanen, Heikki Joensuu, Marko Salmi, Sirpa Jalkanen
INTERNATIONAL JOURNAL OF CANCER
(2016)
Article
Oncology
Alessia Parascandolo, Mikko O. Laukkanen, Nancy De Rosa, Clara Ugolini, Maria Carmela Cantisani, Anna Maria Cirafici, Fulvio Basolo, Massimo Santoro, Maria Domenica Castellone
Article
Oncology
Giancarlo Vecchio, Alessia Parascandolo, Chiara Allocca, Clara Ugolini, Fulvio Basolo, Marco Moracci, Andrea Strazzulli, Beatrice Cobucci-Ponzano, Mikko O. Laukkanen, Maria Domenica Castellone, Nobuo Tsuchida
Article
Multidisciplinary Sciences
Alessia Parascandolo, Francesca Rappa, Francesco Cappello, Jaehyup Kim, David A. Cantu, Herbert Chen, Gianluigi Mazzoccoli, Peiman Hematti, Maria Domenica Castellone, Marco Salvatore, Mikko O. Laukkanen
SCIENTIFIC REPORTS
(2017)
Review
Biochemistry & Molecular Biology
Alessia Parascandolo, Mikko O. Laukkanen
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Medicine, General & Internal
Luise Fuhr, Rukeia El-Athman, Rosella Scrima, Olga Cela, Annalucia Carbone, Henning Knoop, Yin Li, Karen Hoffmann, Mikko O. Laukkanen, Francesco Corcione, Ralf Steuer, Thomas F. Meyer, Gianluigi Mazzoccoli, Nazzareno Capitanio, Angela Relogio
Article
Oncology
Luise Fuhr, Monica Abreu, Annalucia Carbone, Rukeia El-Athman, Fabrizio Bianchi, Mikko O. Laukkanen, Gianluigi Mazzoccoli, Angela Relogio
Article
Cardiac & Cardiovascular Systems
Gennaro Alfano, Deasy Ciervo, Teresa Migliore, Antonia Sorbo, Manuela Ariello, Andrea Vitale, Mikko O. Laukkanen, Salvatore Del Gaudio
Article
Biochemistry & Molecular Biology
Alessia Parascandolo, Mikko O. Laukkanen
Summary: Superoxide dismutase (SOD) family isoenzymes, including SOD1, SOD2, and SOD3, synthesize hydrogen peroxide (H2O2) to regulate signal transduction. The cellular response to SOD3 is dose-dependent, with high concentrations reducing cell survival.
Article
Oncology
Stefania Napolitano, Giulia Martini, Erika Martinelli, Valentina Belli, Alessia Parascandolo, Mikko O. Laukkanen, Vincenzo Sforza, Floriana Morgillo, Davide Ciardiello, Fortunato Ciardiello, Teresa Troiani
Article
Oncology
Carminia Maria Della Corte, Vincenza Ciaramella, Concetta Di Mauro, Maria Domenica Castellone, Federica Papaccio, Morena Fasano, Ferdinando Carlo Sasso, Erika Martinelli, Teresa Troiani, Ferdinando De Vita, Michele Orditura, Roberto Bianco, Fortunato Ciardiello, Floriana Morgillo
