Review
Endocrinology & Metabolism
Esther M. Speksnijder, Gaby V. ten Noever de Brauw, Arjan Malekzadeh, Peter H. Bisschop, Dirk Jan Stenvers, Sarah E. Siegelaar
Summary: A systematic review and meta-analysis study found that postmenopausal hormone therapy (HT) has a neutral-to-beneficial impact on glucose regulation in women with type 2 diabetes, but evidence for women with type 1 diabetes is limited.
Review
Biochemistry & Molecular Biology
Elisa Grillo Araujo, Domitilla Marchiori Sant'Anna Leal de Oliveira, Carolina Castro Martins, Cristine Miron Stefani
Summary: This network meta-analysis investigated the effectiveness of antioxidants as adjuncts to non-surgical periodontal therapy in controlling periodontitis in type 2 diabetes patients. The study found that the use of propolis supplementation to NSPT may result in significant improvement in HbA1c levels, while ALA and melatonin supplementation may contribute to reducing HbA1c levels, although with lower certainty.
Review
Biochemistry & Molecular Biology
Maria Alemany
Summary: Androgens are important steroid hormones with diverse functions including energy control, skeletal maintenance, brain development, and reproductive mechanism regulation. Testosterone plays a key role in maintaining metabolism and its insufficiency is associated with aging and metabolic disorders. T replacement therapy is effective in maintaining core metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Urology & Nephrology
Si Hyun Kim, Jae Joon Park, Ki Hong Kim, Hee Jo Yang, Doo Sang Kim, Chang Ho Lee, Youn Soo Jeon, Sung Ryul Shim, Jae Heon Kim
Summary: This study demonstrated that testosterone replacement therapy (TRT) showed greater improvement in metabolic profiles compared to placebo, especially in markers such as HbA1C, HOMA IR, insulin, and leptin. Further well-designed trials are needed to verify the effects of TRT on lipid profiles. This systematic review suggests that TRT can exert a net beneficial effect on metabolic profiles.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Nutrition & Dietetics
George Siopis, Stephen Colagiuri, Margaret Allman-Farinelli
Summary: The study aimed to compare the effects of nutrition therapy delivered by dietitians to nutrition advice by other healthcare professionals on metabolic parameters in adults with type 2 diabetes. Results showed that nutrition therapy provided by dietitians was associated with better clinical parameters, particularly improved glycemic control.
CLINICAL NUTRITION
(2021)
Article
Cell & Tissue Engineering
Yanju Li, Feiqing Wang, Huiling Liang, Dongxin Tang, Mei Huang, Jianing Zhao, Xu Yang, Yanqing Liu, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: The meta-analysis included 10 studies with a total of 239 participants, evaluating the efficacy of mesenchymal stem cells (MSCs) therapy in treating diabetes mellitus. The results showed that MSC treatment led to significantly lower HbA1c levels, higher fasting C-peptide levels, and reduced insulin requirement in T1DM patients.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Endocrinology & Metabolism
D. G. Corona, W. Vena, A. Pizzocaro, G. Rastrelli, C. Sparano, A. Sforza, L. Vignozzi, M. Maggi
Summary: The purpose of this study is to analyze the relationship between metabolic syndrome (MetS) and erectile dysfunction (ED). The results show that MetS is closely associated with an increased risk of ED, but it is not a useful diagnostic category for studying ED. Treating the individual components of MetS is important in determining ED.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Tomohiro Iwakura, Takanori Yasu, Takashi Tomoe, Asuka Ueno, Takushi Sugiyama, Naoyuki Otani, Shinya Kawamoto, Hiroyuki Nakajima
Summary: Pemafibrate treatment reduces triglyceride and remnant lipoprotein levels in patients with type 2 diabetes or metabolic syndrome.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Naina Kumari, Anoosha Khan, Usman Shaikh, Kimberly Lobes, Deepak Kumar, F. N. U. Suman, Naila S. Bhutto, Faryal Anees, Simra Shahid, Amber Rizwan
Summary: This study found that total testosterone level was significantly lower in type 2 diabetic patients compared to non-diabetic patients, with a higher prevalence of androgen deficiency in the diabetic group. There was also a significant decline in total testosterone level with increasing duration of diabetes. Therefore, a strong interlink between type 2 diabetes mellitus and low testosterone level has been highlighted.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Endocrinology & Metabolism
Jingxuan Lian, Jianfang Fu
Summary: Pioglitazone can significantly improve liver histological performance and insulin sensitivity, as well as significantly reduce fasting blood glucose, glycosylated hemoglobin, plasma AST, ALT and other liver biological indicators. Long-term studies are still needed to verify its efficacy and safety due to the lack of relevant randomized controlled trials and short intervention times.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Rebuma Belete, Zerihun Ataro, Ahmedmenewer Abdu, Merga Sheleme
Summary: This study aimed to estimate the prevalence of metabolic syndrome among type 1 diabetes mellitus patients. The pooled prevalence was 23.7%, with variations across geographical regions and genders. Attention should be given to prevention and control strategies to reduce the morbidity and mortality associated with metabolic syndrome in this population.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Review
Endocrinology & Metabolism
Eva Xepapadaki, Ioanna Nikdima, Eleftheria C. Sagiadinou, Evangelia Zvintzou, Kyriakos E. Kypreos
Summary: The level of HDL-C and the functionality of HDL particles are correlated with the pathogenesis and prognosis of type 2 diabetes mellitus. High blood sugar leads to reduced levels of HDL-C and worsened HDL functionality, through various changes in the proteome and lipidome of HDL particles. Decreased levels of HDL-C and impaired HDL functionality impact the performance of key organs related to glucose homeostasis, such as the pancreas and skeletal muscles.
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Nutrition & Dietetics
Rodolfo Deusdara, Amanda de Moura Souza, Moyses Szklo
Summary: This study evaluated the additive and multiplicative interactions between components of Metabolic syndrome (MetS) regarding type 2 diabetes mellitus. The results showed that the joint presence of certain components had a stronger association with the prevalence of type 2 diabetes mellitus in adolescents.
Article
Endocrinology & Metabolism
Anna Obermayer, Norbert J. Tripolt, Peter N. Pferschy, Harald Kojzar, Faisal Aziz, Alexander Mueller, Markus Schauer, Abderrahim Oulhaj, Felix Aberer, Caren Sourij, Hansjoerg Habisch, Tobias Madl, Thomas Pieber, Barbara Obermayer-Pietsch, Vanessa Stadlbauer, Harald Sourij
Summary: The study investigated the safety and feasibility of 3 nonconsecutive days of intermittent fasting per week in insulin-treated individuals with type 2 diabetes. The results showed that the intermittent fasting group achieved a significant reduction in HbA(1c) and body weight over 12 weeks, with no severe hypoglycemia.