Review
Cell Biology
Giulia Vallini, Laura Calabrese, Costanza Canino, Emanuele Trovato, Stefano Gentileschi, Pietro Rubegni, Linda Tognetti
Summary: Non-melanoma skin cancers, particularly basal cell carcinoma (BCC), are common neoplasms worldwide. The majority of sporadic BCC cases have mutations in Hedgehog pathway genes, leading to abnormal activation of GLI transcription factors. The management of advanced BCCs, including metastatic and locally advanced cases, that are not eligible for surgery or radiotherapy is challenging. The discovery of mutations in the Hh signaling pathway has led to the development of Hh pathway inhibiting agents, but their use is limited due to adverse events and drug resistance.
Review
Biochemistry & Molecular Biology
Zhenyi Niu, Runsen Jin, Yan Zhang, Hecheng Li
Summary: Lung cancer is a major cause of cancer-related death worldwide, with patients with lung squamous cell carcinoma (LSCC) not benefiting from targeted therapies. Immunotherapy has improved outcomes in cancer patients, but its clinical application in LSCC is hindered by low response rates and adverse events. Understanding the mechanisms of LSCC pathogenesis and the connections between signaling pathways is important for developing more effective treatments. This review discusses classical signaling pathways, potential therapeutic targets, epigenetic and immune checkpoint therapies, and combination strategies for LSCC.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Dermatology
J. Weis, C. Grote, M. Weichenthal, A. Hauschild
Summary: This case study discusses the treatment experience of a 78-year-old female patient with skin cancer. The patient underwent systemic treatment with cemiplimab and sonidegib, achieving significant therapeutic efficacy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Oncology
L. K. Kadian, M. Arora, C. P. Prasad, R. Pramanik, S. S. Chauhan
Summary: Esophageal cancer, particularly ESCC, is a highly lethal malignancy with limited treatment options. Understanding the molecular pathways and identifying novel therapeutic agents are crucial for improving the outcomes of ESCC patients. In this review, the key signaling pathways and their crosstalk during disease progression are discussed, providing insights into the potential targets for targeted cancer therapy in ESCC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Review
Oncology
Yuxi Cheng, Juan Chen, Yuxin Shi, Xiaodan Fang, Zhangui Tang
Summary: The aim of this review is to summarize our studies on the signaling pathways involved in the development of oral cancer and several molecular targeting technologies combined with immune checkpoint therapies to provide new therapeutic strategies for oral squamous cell carcinoma. Oral squamous cell carcinoma accounts for 95% of human head and neck squamous cell carcinoma cases and has a poor prognosis. The mitogen-activated protein kinase (MAPK) signaling pathway is activated in over 50% of human oral cancer cases. We review the research progress on the MAPK signaling pathway and discuss its potential as a therapeutic strategy for oral squamous cell carcinoma.
Review
Biochemistry & Molecular Biology
Luca Di Bartolomeo, Federico Vaccaro, Natasha Irrera, Francesco Borgia, Federica Li Pomi, Francesco Squadrito, Mario Vaccaro
Summary: Canonical and non-canonical Wnt signaling pathways play a significant role in cutaneous carcinogenesis, including modulating the tumor microenvironment, synergizing with the Sonic Hedgehog pathway, and promoting tumor progression and the epithelial-mesenchymal transition. Targeting Wnt pathways could be a promising approach for managing non-melanoma skin cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
McKayla Mickle, Gautam Adhikary, Suruchi Shrestha, Wen Xu, Richard L. Eckert
Summary: VGLL4 inhibits the aggressive cancer phenotype of epidermal SCC by suppressing YAP1/TEAD-dependent pro-cancer signaling, leading to reduced expression of YAP1 target genes and pro-cancer collagen genes.
MOLECULAR CARCINOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Jun Wan, Hongji Dai, Xiaoli Zhang, Sheng Liu, Yuan Lin, Ally-Khan Somani, Jingwu Xie, Jiali Han
Summary: The majority of non-melanoma skin cancer cases are basal cell carcinoma and squamous cell carcinoma which originate from keratinocytes. The incidence of keratinocyte carcinomas in the US is over 5 million per year, three times higher than all other types of cancer combined. Research has shown significant variations in gene expression in these tumors, with novel findings including up-regulation of zinc finger encoding genes in human BCC and a novel link between hedgehog signaling, Wnt signaling, and the cilium.
Review
Biochemistry & Molecular Biology
Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera, Jose Pedraza-Chaverri, Jose D. Solano, Maria Elena Ibarra-Rubio
Summary: Renal cell carcinoma is a highly lethal urological cancer that is highly resistant to chemo and radiotherapy. Obesity and smoking are well-known risk factors for RCC, and surgical resection is the treatment of choice for localized RCC. However, this type of cancer is often diagnosed at late stages and systemic therapies are the option for more advanced stages, although still insufficient. Investigating redox-sensitive molecules and signaling pathways may provide potential targets for redox therapy in RCC.
Article
Dermatology
Yingjian Huang, Yuqian Wang, Yan Wang, Ning Wang, Qiqi Duan, Shengbang Wang, Meng Liu, Muhammad Ahsan Bilal, Yan Zheng
Summary: This study found that LPCAT1 is upregulated in cSCC and promotes cSCC progression through the EGFR signaling pathway, suggesting that LPCAT1 may be a potential target for cSCC treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Oncology
Hongjiao Li, Yao Zhang, Mengmeng Xu, Deqin Yang
Summary: Oral squamous cell carcinoma (OSCC) is a malignant disease with a profound impact on human health and life quality. Traditional treatment methods have limitations, but nanotechnology and newly developed therapies offer hope for targeted therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Mingxin Cao, Enyu Shi, Hanping Wang, Lujia Mao, Qiqi Wu, Xinming Li, Yanjie Liang, Xiaoying Yang, Yinsong Wang, Changyi Li
Summary: Oral squamous cell carcinoma (OSCC) is a common malignant tumor in the head and neck, and traditional treatment methods have limitations. Molecular targeted therapies offer solutions by maximizing anticancer efficacy and minimizing treatment toxicity. Receptor-mediated targeted delivery of anticancer therapeutics is the most promising approach.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Oncology
Eri Sasabe, Ayumi Tomomura, Hangyu Liu, Shinya Sento, Naoya Kitamura, Tetsuya Yamamoto
Summary: The study found that treatment with epidermal growth factor promoted the uptake of oral squamous cell carcinoma cell-derived exosomes into OSCC cells, while EGFR inhibitors could inhibit this process, suggesting that EGFR inhibitors may inhibit the malignant potential of OSCC cells by blocking the uptake of exosomes.
Review
Oncology
Elizabeth Chiang, Haleigh Stafford, Jane Buell, Uma Ramesh, Moran Amit, Priyadharsini Nagarajan, Michael Migden, Dan Yaniv
Summary: Non-melanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma, are extensively influenced by the tumor microenvironment. The interactions within this microenvironment play a crucial role in the promotion of tumor growth and progression. Understanding these interactions has led to the development of immunotherapeutic agents, with ongoing research aiming to discover novel treatments.
Article
Anatomy & Morphology
Ozlem Ucer, Nevin Kocaman
Summary: In this study, the researchers found that Suprabasin protein is increased in expression in squamous cell carcinoma (SCC) and decreases with increasing grade. They also observed no expression of Suprabasin in basal cell carcinoma (BCC). Therefore, Suprabasin can be used as a biomarker to differentiate SCC from BCC.
Letter
Dermatology
Luca Stingeni, Leonardo Bianchi, Elettra Antonelli, Elena Sofia Caroppo, Silvia Mariel Ferrucci, Carlotta Gurioli, Michela Ortoncelli, Gabriella Fabbrocini, Eustachio Nettis, Donatella Schena, Maddalena Napolitano, Massimo Gola, Laura Bonzano, MariaTeresa Rossi, Anna Belloni Fortina, Anna Balato, Ketty Peris, Caterina Foti, Fabrizio Guarneri, Marco Romanelli, Cataldo Patruno, Paola Savoia, Maria Esposito, Filomena Russo, Enzo Errichetti, Tommaso Bianchelli, Luca Bianchi, Giovanni Pellacani, Claudio Feliciani, Annamaria Offidani, Monica Corazza, Giuseppe Micali, Nicola Milanesi, Giovanna Malara, Andrea Chiricozzi, Marta Tramontana, Katharina Hansel
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Marco Rubatto, Nicole Macagno, Ginevra Pastorin, Paolo Fava, Luca Ceroni, Simone Ribero, Pietro Quaglino
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Gianluca Avallone, Carlo Alberto Maronese, Claudio Conforti, Paolo Fava, Luigi Gargiulo, Angelo Valerio Marzano, Cesare Massone, Luca Mastorino, Andrea Paradisi, Alessandro Pileri, Pietro Quaglino, Nathalie Rizzo, Simone Ribero, Gabriele Roccuzzo, Gianluca Tavoletti, Carlo Alberto Vignoli, Iris Zalaudek, Emilio Berti, Silvia Alberti-Violetti
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Marco Rubatto, Franco Picciotto, Giovenale Moirano, Enrico Fruttero, Virginia Caliendo, Silvia Borriello, Nadia Sciamarrelli, Paolo Fava, Rebecca Senetta, Adriana Lesca, Anna Sapino, Desiree Deandreis, Simone Ribero, Pietro Quaglino
Summary: This study evaluated the characteristics of patients with head and neck melanoma who underwent sentinel lymph node biopsy and found that scalp melanomas are more aggressive than non-scalp melanomas. The status of the sentinel lymph node is the strongest predictor for recurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Daria Apostolo, Davide D'Onghia, Stelvio Tonello, Rosalba Minisini, Alessio Baricich, Carla Gramaglia, Filippo Patrucco, Patrizia Zeppegno, Antonio Acquaviva, Piero Emilio Balbo, Luigi Mario Castello, Giuseppe Cappellano, Annalisa Chiocchetti, Chiara Gerevini, Mara Giordano, Fatiha Laaguid, Marcello Manfredi, Davide Raineri, Cristina Rigamonti, Roberta Rolla, Valentina Romano, Marco Confalonieri, Paola Savoia, Elisa Zavattaro, Mario Pirisi, Barbara Ruaro, Pier Paolo Sainaghi, Mattia Bellan
Summary: Post-acute conditions are common after COVID-19, and the underlying mechanisms are not yet fully understood. This study suggests that Gas6 and its soluble receptors, sAxl and sMer, may be implicated in these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Dermatology
Edoardo Cammarata, Astrid Lappi, Claudio Giacomazzi, Lorena Soledad Torre, Paola Savoia, Moreno Dutto
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Oncology
Laura Cristina Gironi, Elia Esposto, Francesca Zottarelli, Roberto Giorgione, Pamela Farinelli, Elisa Zavattaro, Edoardo Cammarata, Nunzia Di Cristo, Paola Ogliara, Lara Camillo, Mara Giordano, Simona Mellone, Barbara Pasini, Alessandro Ambrosi, Paola Savoia
Summary: We investigated the correlation between the occurrence of cutaneous melanoma and noncutaneous tumors in CDKN2A mutation carriers and wild-type melanoma patients. The study found that mutation carriers had a significantly higher number of cutaneous melanoma cases compared to the wild-type patients. Additionally, both groups had a similar rate of diagnosis for malignant NCTs. The onset of cutaneous melanoma generally preceded the occurrence of NCTs, emphasizing the importance of comprehensive surveillance for melanoma patients.
Letter
Dermatology
Stefano Buffon, Silvia Alberti Violetti, Gianluca Avallone, Luigia Venegoni, Angelo Marzano, Luca Mastorino, Paolo Fava, Simone Ribero, Pietro Quaglino, Michela Ortoncelli, Silvia M. Ferrucci
Summary: Dupilumab, a monoclonal antibody targeting interleukin-4 and -13 signalling pathway, has been proven to be effective and safe in atopic dermatitis (AD). However, its potential role in treating or inducing cutaneous T-cell lymphomas (CTCLs) is not fully understood, as case reports suggest both beneficial effects and possible pathogenetic involvement in mycosis fungoides and Sezary syndrome. This study collected data from 995 AD patients who received dupilumab treatment and were followed for a mean period of 25.1 months, aiming to investigate the correlation between dupilumab and the development of CTCLs.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Marco Rubatto, Paolo Fava, Ignazio Stanganelli, Simone Ribero, Jacopo Pigozzo, Anna Maria Di Giacomo, Laura Ridolfi, Maria Chiara Tronconi, Claudia Trojaniello, Melissa Bersanelli, Mattia Garutti, Alice Indini, Ivana De Risi, Michele De Tursi, Barbara Merelli, Francesca Morgese, Marcella Occelli, Gian Carlo Antonini Cappellini, Stefano Poletto, Dahlia Fedele, Sonia Brugnara, Michela Frisinghelli, Luigi Formisano, Raffaele Conca, Marco Tucci, Michelangelo Russillo, Luca Ceroni, Paola Queirolo, Giada Targato, Sabino Strippoli, Mario Mandala, Michele Guida, Pietro Quaglino
Summary: This study aims to evaluate the progression-free survival (PFS) in patients with metastatic melanoma who interrupted anti-PD-1 treatment. The study found that long-lasting clinical responses can be maintained even after discontinuation of anti-PD-1 therapy, with approximately 70.6% of patients who did not achieve complete remission experiencing recurrence after treatment discontinuation.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Dermatology
Federica Veronese, Elia Esposto, Chiara Airoldi, Carla Gramaglia, Lucia Bestagini, Elisa Zavattaro, Patrizia Zeppegno, Paola Savoia
Summary: This study is a Randomized Control Trial (RCT) evaluating the effectiveness of an emollient and rehydrating topical product in healthcare workers with hand eczema during the COVID-19 pandemic. The data showed that patients treated with the tested product had greater reductions in clinical and psychological scores compared to those treated with a basic cream. The study also confirmed the connection between dermatological and psychological indicators.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Review
Microbiology
Paola Savoia, Barbara Azzimonti, Roberta Rolla, Elisa Zavattaro
Summary: The skin and gut host various microorganisms that interact with the immune system and affect immune tolerance and inflammation. Changes in the skin microbiota have been observed in skin diseases, including skin cancer. Modulating the microbiota could be a potential therapeutic option for advanced skin cancers.
Editorial Material
Medicine, General & Internal
Elisa Zavattaro, Federica Veronese, Paola Savoia
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Federica Veronese, Elia Esposto, Chiara Airoldi, Carla Gramaglia, Patrizia Zeppegno, Elisa Zavattaro, Paola Savoia
Summary: This study aimed to estimate the prevalence of self-reported hand eczema signs and symptoms among healthcare workers in a Northern Italy University Hospital after the third wave of the COVID-19 pandemic. Results showed that 51.1% of respondents self-reported suffering from at least one hand skin lesion. The healthcare group had a higher daily hand washing frequency and a higher prevalence of hand eczema signs compared to the administrative staff.
MEDICINA-LITHUANIA
(2023)
Article
Biochemical Research Methods
Francesca Di Cesare, Matteo Calgaro, Veronica Ghini, Diletta Francesca Squarzanti, Annachiara De Prisco, Annalisa Visciglia, Paola Zanetta, Roberta Rolla, Paola Savoia, Angela Amoruso, Barbara Azzimonti, Nicola Vitulo, Leonardo Tenori, Claudio Luchinat, Marco Pane
Summary: This study investigated the effects of probiotic treatment on the metabolic profiles of human urine and serum using NMR-based metabonomic approach. The results showed significant impacts of probiotics on urinary and serum metabolomes, without altering their phenotypes. The study demonstrated the variations of metabolite levels resulting from different probiotic posologies.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Medicine, General & Internal
Lara Camillo, Elia Esposto, Laura Cristina Gironi, Chiara Airoldi, Shahd Abdullah Alhamed, Renzo Luciano Boldorini, Elisa Zavattaro, Paola Savoia
Summary: This study evaluated the correlation between the expression of AQP1, AQP8, and AQP9 and the clinical outcomes of malignant melanoma (MM) patients. The results showed that AQPs were more highly expressed in superficial spreading melanoma (SSM), suggesting a potential correlation with prognosis. Further analysis revealed that AQP1 was associated with specific body sites and low mitotic index, AQP8 with negative sentinel lymph node, and AQP9 with Breslow thickness and lack of ulcerations. The findings suggest that the expression of AQP1, AQP8, and AQP9 may be correlated with a better prognosis for malignant melanoma.
JOURNAL OF CLINICAL MEDICINE
(2023)