Review
Gastroenterology & Hepatology
Mahsa Taghiakbari, Yuichi Mori, Daniel von Renteln
Summary: Colonoscopy is an effective screening procedure in colorectal cancer prevention programs, and AI-assisted decision support systems show promise in improving the detection and classification of colorectal polyps and cancer. However, challenges remain in determining their real-time application value in clinical practice due to limitations in model design, validation, and testing under real-life conditions.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Health Care Sciences & Services
Ka Luen Thomas Lui, Sze Hang Kevin Liu, Kathy Leung, Joseph T. Wu, Ann G. Zauber, Wai Keung Leung
Summary: The widespread adoption of computer-aided detection (CADe) in detecting colorectal polyps would result in shorter surveillance intervals for patients, particularly according to the US Multi-Society Task Force on Colorectal Cancer (USMSTF) guideline. Based on simulation, CADe application would lead to approximately 19.1% and 1.9% of patients requiring shorter surveillance intervals, as recommended by the USMSTF and European Society of Gastrointestinal Endoscopy (ESGE) guidelines, respectively. Specifically, all or 2.7% of patients initially scheduled for 3-5 years of surveillance would have their intervals shortened to 3 years, according to the USMSTF guideline.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Aasma Shaukat, David R. Lichtenstein, Samuel C. Somers, Daniel C. Chung, David G. Perdue, Murali Gopal, Daniel R. Colucci, Sloane A. Phillips, Nicholas A. Marka, Timothy R. Church, William R. Brugge
Summary: This study evaluated the clinical benefit and safety of using a computer-aided detection (CADe) device in colonoscopy procedures. The results showed that the use of CADe device significantly increased adenoma detection rate without increasing the resection of non-neoplastic lesions.
Review
Gastroenterology & Hepatology
Rajesh N. Keswani, Seth D. Crockett, Audrey H. Calderwood
Summary: The purpose of this study was to provide best practice advice on improving the quality of screening and surveillance colonoscopy, but no formal rating of evidence quality or strength of recommendation was conducted.
Article
Medicine, General & Internal
Manuel Zorzi, Giulio Antonelli, Claudio Barbiellini Amidei, Jessica Battagello, Bastianello Germana, Flavio Valiante, Stefano Benvenuti, Alberto Tringali, Francesco Bortoluzzi, Erica Cervellin, Davide K. Giacomin, Tamara Meggiato, Erik Rosa-Rizzotto, Diego Fregonese, Manuela Dinca, Gianluca Baldassarre, Paola Scalon, Maurizio Pantalena, Luisa Milan, Gianmarco Bulighin, Daniele Di Piramo, Maurizio Azzurro, Armando Gabbrielli, Alessandro Repici, Douglas Rex, Massimo Rugge, Cesare Hassan
Summary: In a FIT-based screening program, there is an inverse association between ADR and the risk of PCCRC, highlighting the importance of monitoring colonoscopy quality. Increasing endoscopists' ADR can significantly reduce the risk of PCCRC.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Paolo Biamonte, Ferdinando D'Amico, Ernesto Fasulo, Rukaia Bara, Francesca Bernardi, Mariangela Allocca, Alessandra Zilli, Silvio Danese, Federica Furfaro
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Recent advancements in endoscopic technology have revolutionized the assessment and treatment of UC patients, enabling early detection of dysplasia and cancer, more precise characterization of the disease, and more targeted biopsies. These advancements have significant implications for therapeutic decision making, empowering clinicians to consider various treatment options.
Review
Oncology
Marcello Maida, Giovanni Marasco, Antonio Facciorusso, Endrit Shahini, Emanuele Sinagra, Socrate Pallio, Daryl Ramai, Alberto Murino
Summary: Artificial intelligence in gastrointestinal endoscopy has promising applications, such as interpreting medical images and increasing sensitivity during examinations. Computer-aided detection (CADe) systems improve adenoma detection rate and reduce miss rate. Computer-aided characterization (CADx) and computer-aided quality (CADq) systems aim to assess lesion types and standardize quality measures, respectively.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Review
Gastroenterology & Hepatology
Lihui Zhang, Liwen Yao, Zihua Lu, Honggang Yu
Summary: High-quality Esophagogastroduodenoscopy (EGD) screening is essential for early diagnosis and prevention of upper gastrointestinal (UGI) cancer, but there is significant variation in performance and suboptimal quality control. This review discusses the key points for quality assurance in EGD screening based on current guidelines and evidence, and explores the emerging role of artificial intelligence in EGD quality control, aiming to improve the overall quality of EGD screening.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Emanuele Rondonotti, Dhanai Di Paolo, Erik Rosa Rizzotto, Costanza Alvisi, Elisabetta Buscarini, Marco Spadaccini, Giacomo Tamanini, Silvia Paggi, Arnaldo Amato, Giulia Scardino, Samanta Romeo, Saverio Alicante, Fabio Ancona, Ennio Guido, Vincenza Marzo, Fabio Chicco, Simona Agazzi, Cesare Rosa, Loredana Correale, Alessandro Repici, Cesare Hassan, Franco Radaelli
Summary: The use of CADe in a FIT-based CRC screening program significantly increases the adenoma detection rate and the number of adenomas per colonoscopy. The impact of CADe appears to be consistent regardless of the endoscopist's baseline ADR.
Article
Gastroenterology & Hepatology
Hong Xu, Raymond S. Y. Tang, Thomas Y. T. Lam, Guijun Zhao, James Y. W. Lau, Yunpeng Liu, Qi Wu, Long Rong, Weiran Xu, Xue Li, Sunny H. Wong, Shuntian Cai, Jing Wang, Guanyi Liu, Tantan Ma, Xiong Liang, Joyce W. Y. Mak, Hongzhi Xu, Peng Yuan, Tingting Cao, Fudong Li, Zhenshi Ye, Zhang Shutian, Joseph J. Y. Sung
Summary: This multicenter randomized controlled trial found that AI-assisted colonoscopy improves polyp detection and characterization in an asymptomatic population. AI-assisted colonoscopy can increase the adenoma detection rate and the detection ability of both expert and non-expert endoscopists.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Health Care Sciences & Services
Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee, Young Joo Yang, Gwang Ho Baik
Summary: This study evaluated the impact of volume and distribution of training datasets on the development of a deep-learning model for predicting colorectal polyp histopathology from endoscopic images. The results showed that doubling the proportion of data for fewer categories improved the accuracy of the model. This research is important for the standardized creation of artificial intelligence models in gastrointestinal endoscopy.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Surgery
Shuen-Ern Chin, Fang-Ting Wan, Jasmine Ladlad, Koy-Min Chue, Eng-Kiong Teo, Cui-Li Lin, Fung-Joon H. Foo, Frederick Koh
Summary: This study evaluates the 1-year performance of AI-aided colonoscopy, showing that it is a cost-effective means of improving colonoscopy quality and advancing colorectal cancer screening in Singapore.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Frederick H. Koh, Jasmine Ladlad, Eng-Kiong Teo, Cui-Li Lin, Fung-Joon Foo
Summary: This study evaluates the performance of real-time AI-aided colonoscopy in the detection of colonic polyps. The results show that using real-time AI-aided colonoscopy can improve the detection rate of colonic polyps, even for experienced endoscopists. This will improve the quality of colonoscopy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Oncology
Hirotaka Oura, Tomoaki Matsumura, Mai Fujie, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Mamoru Tokunaga, Tatsuya Kaneko, Yushi Imai, Tsubasa Oike, Yuya Yokoyama, Naoki Akizue, Yuki Ota, Kenichiro Okimoto, Makoto Arai, Yuki Nakagawa, Mari Inada, Kazuya Yamaguchi, Jun Kato, Naoya Kato
Summary: The DCSS exhibited excellent capability in detecting lesions and pointing out low-quality images, with detection accuracy reaching 93.2% for EGC and 92.5% for ML, and over 80% accuracy in detecting low-quality images.
Review
Oncology
Edward Young, Louisa Edwards, Rajvinder Singh
Summary: Artificial intelligence (AI) systems have become increasingly available in the field of endoscopy, particularly in colonoscopy. This comprehensive review focuses on the application of AI in detecting and characterizing colorectal polyps, with the goal of improving the efficacy of colorectal cancer screening and prevention. AI-driven algorithms show potential in addressing the challenge of overlooked polyps and empowering gastroenterologists to accurately characterize polyps without extensive training in advanced mucosal imaging. By integrating AI technologies into routine colonoscopy, the detection and characterization of polyps can be advanced, potentially leading to more effective colorectal cancer screening and prevention.
Article
Gastroenterology & Hepatology
Emanuele Rondonotti, Cesare Hassan, Giacomo Tamanini, Giulio Antonelli, Gianluca Andrisani, Giovanni Leonetti, Silvia Paggi, Arnaldo Amato, Giulia Scardino, Dhanai Di Paolo, Giovanna Mandelli, Nicoletta Lenoci, Natalia Terreni, Alida Andrealli, Roberta Maselli, Marco Spadaccini, Piera Alessia Galtieri, Loredana Correale, Alessandro Repici, Francesco Maria Di Matteo, Luciana Ambrosiani, Emanuela Filippi, Prateek Sharma, Franco Radaelli
Summary: The present study demonstrates that real-time artificial intelligence (AI)-assisted optical diagnosis is accurate and useful for the diagnosis of diminutive rectosigmoid polyps (DRSPs), especially for nonexperts.
Review
Gastroenterology & Hepatology
Virginia Solitano, Antonio Facciorusso, Tine Jess, Christopher Ma, Cesare Hassan, Alessandro Repici, Vipul Jairath, Alessandro Armuzzi, Siddharth Singh
Summary: In patients with inflammatory bowel diseases (IBDs), no significant difference in the risk of serious infections was observed between advanced therapies. Vedolizumab may have a lower risk of serious infections compared to TNFa antagonists in patients with ulcerative colitis, but not in Crohn's disease. Ustekinumab may be more effective than TNFa antagonists and vedolizumab in patients with Crohn's disease.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Benedetto Mangiavillano, Federica Calabrese, Francesco Auriemma, Danilo Paduano, Alessandro De Marco, Alessandro Repici
Article
Gastroenterology & Hepatology
Francesco Auriemma, Emanuele Dabizzi, Antonio Facciorusso, Silvia Carrara, Germana de Nucci, Giampiero Manes, Laura Lamonaca, Danilo Paduano, Andrew Ofosu, Stefano Francesco Crino, Alessandro Repici, Benedetto Mangiavillano
Summary: This study aimed to evaluate the diagnostic accuracy of EUS plus FNA/FNB in suspected local recurrence of pelvic masses. The results showed that EUS-FNB had higher sensitivity and lower uncertainty in diagnosing pelvic masses, highlighting its importance in oncological follow-up.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Giulia Rizzo, Federica Rubbino, Sudharshan Elangovan, Giusy Sammarco, Sara Lovisa, Silvia Restelli, Samuel Elias Pineda Chavez, Luca Massimino, Luigi Lamparelli, Marianna Paulis, Annalisa Maroli, Giulia Roda, Mohammad Shalaby, Michele Carvello, Caterina Foppa, Sheona P. Drummond, Paola Spaggiari, Federica Ungaro, Antonino Spinelli, Alberto Malesci, Alessandro Repici, Anthony J. Day, Alessandro Armuzzi, Silvio Danese, Stefania Vetrano
Summary: This study investigated the tissue changes in perianal fistula and explored the dysregulation of extracellular matrix (ECM) homeostasis in fistula formation. They found that TNFAI6 (encoding TSG-6) was significantly upregulated in the fistula and played a role in the formation of a crosslinked ECM. TSG-6 mediated changes in ECM organization and triggered the activation of the epithelial-mesenchymal transition transcription factor SNAI1 through mechano-sensitive proteins.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Cesare Hassan, Alessandro Repici, Tommy Rizkala, Michal F. F. Kaminski
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Editorial Material
Gastroenterology & Hepatology
Alessandro Fugazza, Marta Andreozzi, Matteo Colombo, Glenn Koleth, Davide Massimi, Marco Spadaccini, Alessandro Repici
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Hayato Kurihara, Cecilia Binda, Matteo Maria Cimino, Raffaele Manta, Guido Manfredi, Andrea Anderloni
Summary: Acute cholecystitis is a common disease in clinical practice. Laparoscopic cholecystectomy is the standard treatment, but it may be too risky for certain patients. Non-operative treatments such as percutaneous gallbladder drainage, endoscopic transpapillary gallbladder drainage, and EUS-guided drainage can be effective alternatives. These options should be considered in a stepwise approach after an accurate evaluation in a multidisciplinary discussion.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Kien Vu Trung, Einas Abou-Ali, Fabrice H. Caillol, Woo Paik, Bertrand Napoleon, Viliam E. Masaryk, Sophia van der Wiel, Enrique Perez-Cuadrado-Robles, Nicolas Musquer, Asif Halimi, Kevin R. Soares, Francois Souche, Steffen C. Seyfried, Maria Petrone, Stefano Crippa, Tobias Kleemann, David J. Albers, Tobias Weismueller, Ana Dugic, Benjamin Meier, Edris Wedi, Moritz Schiemer, Sara Regner, Sebastien Gaujoux, Marcus Hollenbach, Francesco Auriemma, Aiste Gulla, Elias Karam, Marc Giovannini, Jean-Philippe Ratone, Uwe Will, Rita Saadeh, Marco J. Bruno, Pierre Deprez, Urban Arnelo, Erik Haraldsson, Alexander Waldthaler, Galen Leung, Mark A. Schattner, William R. Jarnagin, Tiegong Wang, Jean M. Fabre, Georg Kaehler, Alberto Mariani, Piera Zaccari, Giulio Belfiori, Massimo Falconi, Stefano Partelli, Alessandro Repici, Andrea Anderloni, Johanna Laukkarinen, Albrecht Hoffmeister, Jonas Rosendahl, Brigitte Schumacher, Louise Barbier, Dominik Heling, Steffen Muehldorfer, Stephanie Truant, Karel Caca, Marcel Tantau, Katrin Salzmann, Patrice David, Arthur Schmidt, Tullio Piardi, J. Matthias Loehr, Johan Gagniere, Bogdan P. Miutescu, Arthur Berger, Peter Schemmer, Christian Heise, Vasile Sandru, Reea Ahola, Mario Dinis-Ribeiro, Tiago Curdia Goncalves, Doerte Wichmann
Summary: This study retrospectively analyzed the outcomes of endoscopic papillectomy in FAP-related and sporadic ampullary lesions. The study found that endoscopic papillectomy is safe and effective for FAP-related ampullary lesions, and FAP patients require long-term surveillance.
Article
Gastroenterology & Hepatology
Ludovica Venezia, Matteo Rossano Buonocore, Ilenia Barbuscio, Francesco Bortoluzzi, Fabio Monica, Guido Manfredi, Andrea Anderloni, Elisa Stasi
Summary: The Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) released five recommendations to improve the management of gastrointestinal diseases and enhance healthcare quality as part of the 'Choosing Wisely' international campaign.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Marco Spadaccini, Davide Massimi, Yuichi Mori, Ludovico Alfarone, Alessandro Fugazza, Roberta Maselli, Prateek Sharma, Antonio Facciorusso, Cesare Hassan, Alessandro Repici
Summary: Colorectal cancer is the third most common cancer worldwide, with the highest incidence in high-income countries. A well-designed endoscopic screening program can significantly reduce colorectal cancer incidence and mortality. Artificial intelligence (AI) applications in endoscopy, specifically machine and deep learning, have the potential to automatically extract specific features from endoscopic images/videos, assisting endoscopists in various aspects of their practice. This review aims to summarize the current knowledge on AI-aided endoscopy and its potential role in colorectal cancer prevention.
Review
Gastroenterology & Hepatology
Antonio Facciorusso, Stefano Francesco Crino, Alessandro Fugazza, Silvia Carrara, Marco Spadaccini, Matteo Colombo, Daryl Ramai, Benedetto Mangiavillano, Saurabh Chandan, Paraskevas Gkolfakis, Babu Mohan, Cesare Hassan, Alessandro Repici
Summary: This study compared the performance of endoscopic tissue sampling techniques for subepithelial lesions and found that EUS-FNB and MIAB had better performance, while bite-on-bite sampling was significantly inferior. MIAB showed better results for lesions smaller than 20 mm, and EUS-FNA remained competitive when ROSE was available.
Review
Medicine, General & Internal
Alessandro Fugazza, Marta Andreozzi, Alessandro De Marco, Leonardo Da Rio, Matteo Colombo, Marco Spadaccini, Silvia Carrara, Marco Giacchetto, Mrigya Sharma, Vincenzo Craviotto, Anita Busacca, Chiara Ferrari, Alessandro Repici
Summary: This narrative review provides an overview of the application of endoscopic ultrasound-guided biliary drainage (EUS-BD) for the treatment of malignant biliary obstruction, with a focus on EUS-guided gallbladder drainage (EUS-GBD) using lumen apposing metal stent (LAMS). EUS-BD has shown high rates of technical and clinical success, with fewer adverse events compared to percutaneous trans-hepatic biliary drainage (PTBD). It is currently considered as the preferred alternative technique for biliary drainage in patients with distal malignant biliary obstruction (DMBO) after failed endoscopic retrograde cholangiopancreatography (ERCP).
Meeting Abstract
Gastroenterology & Hepatology
Elisabetta Mastrorocco, Maria Terrin, Giulia Migliorisi, Benedetta Masoni, Valeria Farinola, Diletta De Deo, Silvia Ferretti, Valeria Poletti, Miriana Mercurio, Bianca Bartocci, Marco Spadaccini, Piera Alessia Galtieri, Gaia Pellegatta, Elisa Chiara Ferrara, Silvia Carrara, Uzma D. Siddiqui, Amrita Sethi, Alessandro Repici, Roberta Maselli
