Article
Immunology
Dengyong Xu, Yao Chen, Xing Gao, Weidong Xie, Ya Wang, Jiaying Shen, Guang Yang, Binbin Xie
Summary: This study conducted a two-sample Mendelian randomization analysis and found a causal relationship between inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), and low total body bone mineral density (BMD) and osteoporosis (OS).
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Gastroenterology & Hepatology
Kelly Lambert, Daniel Pappas, Chiara Miglioretto, Arefeh Javadpour, Hannah Reveley, Laura Frank, Michael C. Grimm, Dorit Samocha-Bonet, Georgina L. Hold
Summary: This study conducted a systematic evaluation and meta-analysis of the dietary intake of adults with inflammatory bowel disease (IBD), revealing that all subgroups of IBD patients have inadequate intake of energy, fiber, folate, and calcium. Additionally, their intake of various food groups is also insufficient, and compared to healthy individuals, IBD patients consume significantly less dietary fiber. Further research is needed to improve diet quality and understand factors influencing dietary intake in IBD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Endocrinology & Metabolism
Panagiotis Anagnostis, Kalliopi Lampropoulou-Adamidou, Julia K. Bosdou, Georgios Trovas, Petros Galanis, Efstathios Chronopoulos, Dimitrios G. Goulis, Symeon Tournis
Summary: The optimal management of pregnancy and lactation-associated osteoporosis (PLO) has not been determined. Existing studies have found that calcium/vitamin D, bisphosphonates, and teriparatide can improve bone mineral density, with teriparatide showing better efficacy. However, due to heterogeneity and lack of robust comparative data, safe conclusions cannot be drawn regarding the optimal therapeutic intervention in women with PLO.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Y. Zhang, Z. Tian, S. Ye, Q. Mu, X. Wang, S. Ren, X. Hou, W. Yu, J. Guo
Summary: The study found that individuals with Down syndrome have significantly lower bone mineral density in total body and different regions (hip, lumbar spine, and femoral neck) compared to controls. It also showed a decreasing trend in lumbar spine volumetric bone mineral density and an elevated femoral neck volumetric bone mineral density in Down syndrome individuals versus controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Smoking is a major modifiable risk factor for osteoporosis and can lead to various chronic diseases, including inflammatory bowel disease. Nicotine and compounds in cigarette smoke impact the RANK-RANKL-OPG pathway, intestinal microbiota composition, and calcium-phosphate balance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Chia-Hsien Chen, Wei-Cheng Lo, Ping-Jen Hu, Hsiu-Chen Chan, Wan-Chen Shen, Mai-Szu Wu, Mei-Yi Wu
Summary: From network meta-analysis, it was found that teriparatide and denosumab appear to be the most effective treatments for preventing bone loss and reducing the risk of fracture in patients with CKD or a history of kidney transplantation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Bin Wu, Xiu-Fang Zhu, Xiao-Qiang Yang, Wei-Yi Wang, Jian-Hua Lu
Summary: The active compound osthole derived from Cnidium monnieri Cusson has shown to be effective in treating osteoporosis in rats, promoting bone formation and inhibiting bone absorption.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Xiaowen Zhang, Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study investigated the relationship between bone mineral density (BMD) and the risk of incident dementia, and found that higher BMD was associated with a reduced risk of dementia, particularly in women. Further research is needed to evaluate the clinical usefulness of BMD in predicting and managing dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Review
Geriatrics & Gerontology
Charlotte Beaudart, Celine Demonceau, Shaun Sabico, Nicola Veronese, Cyrus Cooper, Nicholas Harvey, Nicholas Fuggle, Olivier Bruyere, Rene Rizzoli, Jean-Yves Reginster
Summary: This systematic review and meta-analysis aimed to evaluate the efficacy of pharmacological treatments in men with osteoporosis. The analysis showed that treatment improved bone mineral density and reduced the incidence of fractures in men with osteoporosis.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
N. Panahi, B. Arjmand, A. Ostovar, E. Kouhestani, R. Heshmat, A. Soltani, B. Larijani
Summary: Due to the metabolic nature of osteoporosis, researchers have recently considered metabolomic studies. This systematic review showed that metabolic profiling, including metabolites from different categories, could enhance the diagnosis of low BMD. However, significant heterogeneity was observed in the studies, necessitating further research to address and minimize it.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Environmental Sciences
Seyed Rohallah Mousavibaygei, Amir Bisadi, Fariba ZareSakhvidi
Summary: This study systematically reviewed the evidence on the association between exposure to air pollution and osteoporosis-related outcomes. The findings suggest that PM2.5, PM10, and nitrogen dioxide may be associated with decreased bone density, osteoporotic fractures, and osteoporosis. However, due to limitations in the number of studies, heterogeneity, and publication bias, caution should be exercised in interpreting the results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Endocrinology & Metabolism
Elena Tsourdi, M. Carola Zillikens, Christian Meier, Jean-Jacques Body, Elena Gonzalez Rodriguez, Athanasios D. Anastasilakis, Bo Abrahamsen, Eugene McCloskey, Lorenz C. Hofbauer, Nuria Guanabens, Barbara Obermayer-Pietsch, Stuart H. Ralston, Richard Eastell, Jessica Pepe, Andrea Palermo, Bente Langdahl
Summary: Discontinuation of denosumab results in increased bone turnover, rapid bone loss, and risk of multiple vertebral fractures in some patients. Prior bisphosphonate therapy or subsequent antiresorptive treatment may help mitigate the biochemical rebound phenomenon after denosumab discontinuation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ruth Durdin, Camille Parsons, Elaine M. Dennison, Suzanne Williams, Therese Tillin, Nishi Chaturvedi, Cyrus Cooper, Nicholas C. Harvey, Kate A. Ward
Summary: The study aimed to investigate whether central adiposity or inflammatory status contribute to ethnic differences in bone mineral density (BMD). The study found that despite adjustment for body composition, central adiposity, and inflammation, ethnic differences in BMD still existed. Additionally, ethnic differences were observed in the relationship between BMI, LMI or VAT mass and lumbar spine BMD in women.
Review
Biochemistry & Molecular Biology
Salma, Syed Sufian Ahmad, Shahid Karim, Ibrahim M. Ibrahim, Huda M. Alkreathy, Mohammed Alsieni, Mohammad Ahmed Khan
Summary: Adequate intake of Vitamin K is associated with improved skeletal health and decreased fracture risk. However, there is insufficient evidence regarding the significant impact of Vitamin K on femoral neck bone density.
Article
Gastroenterology & Hepatology
Gorm Roager Madsen, Kristina Bertl, Nikolaos Pandis, Andreas Stavropoulos, Johan Burisch
Summary: In this questionnaire-based study, periodontitis was found to be significantly associated with increased IBD disease activity in the last 12 months, as well as increased IBD disability.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Joana Torres, Catarina Gomes, Camilla Jensen, Manasi Agrawal, Francisco Morao, Tine Jess, Jean-Frederic Colombel, Kristine H. Allin, Johan Burisch
Summary: In this study, risk factors for unaffected first-degree relatives (FDRs) of inflammatory bowel disease (IBD) patients to develop the disease were identified. These findings provide an opportunity for counseling IBD relatives.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
M. Z. Sarikaya, M. Zhao, B. Lo, F. Bendtsen, J. Burisch
Summary: This nationwide cohort study aimed to investigate the disease course in Crohn's disease patients who underwent early and late major abdominal surgery. The study found that patients who underwent surgery within 29 days of diagnosis had a lower cumulative risk of re-operation and a shorter cumulative exposure to immunomodulators in the initial years after surgery.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Hannah Gordon, Livia Biancone, Gionata Fiorino, Konstantinos H. Katsanos, Uri Kopylov, Eman Al Sulais, Jordan E. Axelrad, Karthiha Balendran, Johan Burisch, Lissy de Ridder, Lauranne Derikx, Pierre Ellul, Thomas Greuter, Marietta Iacucci, Caroline Di Jiang, Christina Kapizioni, Konstantinos Karmiris, Julien Kirchgesner, David Laharie, Triana Lobaton, Tamas Molnar, Nurulamin M. Noor, Rohit Rao, Simone Saibeni, Michael Scharl, Stephan R. Vavricka, Tim Raine
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Sigrun Grimsdottir, Mohamed Attauabi, Emilie Kristine Dahl, Johan Burisch, Jakob Benedict Seidelin
Summary: A systematic review found that a high proportion of patients with inflammatory bowel disease (IBD) experience flares following cancer treatment, with an increased risk of gastrointestinal toxicity in IBD patients receiving immune checkpoint inhibitor treatment. However, current studies suggest that IBD flares induced by cancer therapy can be managed and should not prevent appropriate cancer treatments.
JOURNAL OF CROHNS & COLITIS
(2023)
Editorial Material
Gastroenterology & Hepatology
Johan Burisch
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Psychology, Clinical
Simon R. Knowles, Stephan P. Moller, Andreas Stengel, Antonina Mikocka-Walus, Nuno Ferreira, Ines A. Trindade, Anna Mokrowiecka, Johan Burisch, Manuel Barreiro-de Acosta, Charles N. Bernstein, Bobby Lo, David Skvarc
Summary: The aim of this longitudinal study was to examine changes in COVID-19 and illness-related perceptions, gastrointestinal symptoms, coping, catastrophising, psychological distress, and QoL during the COVID-19 pandemic. A total of 831 adults with a gastrointestinal condition completed an online questionnaire at baseline (May-October 2020). Of those, 270 (32.5%) participants (85.2% female, mean age = 47.3 years) provided follow-up data (March-May 2021). The results showed that gastrointestinal symptoms and COVID-19 perceptions at follow-up were strongly predicted by their baseline values, while illness perceptions were predicted by baseline gastrointestinal symptoms. Cross-lagged relationships indicated a reciprocal relationship between gastrointestinal symptoms and psychological distress. Moreover, gastrointestinal symptoms had substantial predictive utility, strongly predicting future gastrointestinal symptoms, and to a lesser extent, more negative illness perceptions, greater psychological distress, and greater use of adaptive coping strategies across time.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2023)
Editorial Material
Gastroenterology & Hepatology
Johan Burisch
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Uri Kopylov, Johan Burisch, Shomron Ben-Horin, Fiona Braegger, Alonso Fernandez-Nistal, Nuria Lara, Henriette Sophie Heinrich, Stephan R. Vavricka
Summary: This study demonstrated that vedolizumab treatment resulted in improvements in extraintestinal manifestations in patients with IBD, showing its effectiveness and good safety profile.
INFLAMMATORY BOWEL DISEASES
(2023)
Letter
Dermatology
Valdemar W. Nielsen, Astrid-Helene R. Jorgensen, Yiqiu Yao, Hans C. Ring, Mohamed Attauabi, Gorm R. Madsen, Johan Burisch, Simon F. Thomsen
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kristoffer Jarlov Jensen, Camilla Bjorn Jensen, Christina Wennerstroem, Johan Burisch, Janne Petersen
Summary: This study aimed to characterize the drug utilization and switch patterns of biological treatment for ulcerative colitis (UC) and Crohn's disease (CD). The majority of UC and CD patients initiating biologic therapy chose infliximab as their first-line treatment. Adalimumab had a higher risk of treatment discontinuation compared to infliximab, while vedolizumab had a lower risk of discontinuation for UC patients.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Sofie Ingdam Halkjaer, Bobby Lo, Frederik Cold, Alice Hojer Christensen, Savanne Holster, Julia Konig, Robert Jan Brummer, Olga C. Aroniadis, Perttu Lahtinen, Tom Holvoet, Lise Lotte Gluud, Andreas Munk Petersen
Summary: Fecal microbiota transplantation (FMT) has been suggested as a treatment for irritable bowel syndrome (IBS), but the efficacy and safety of FMT for IBS remain unclear. This review found insufficient evidence to support or refute the use of FMT for IBS. Larger trials are needed to further evaluate its effectiveness.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Medicine, General & Internal
Mohamed Attauabi, Emilie Kristine Dahl, Johan Burisch, John Gubatan, Ole Haagen Nielsen, Jakob Benedict Seidelin
Summary: This study compared the onset of efficacy of biological therapies and small molecules in patients with moderate-to-severe ulcerative colitis (UC). The results showed that upadacitinib had significantly better clinical response and clinical remission at two weeks compared to other agents, while ustekinumab and ozanimod had the lowest efficacy.
Article
Dentistry, Oral Surgery & Medicine
Kristina Bertl, Georgios Tsakos, Nikolaos Pandis, Anna Bogren, Johan Burisch, Andreas Stavropoulos
Summary: This study is the first to find that oral health problems are associated with the disease-specific quality of life (QoL) of inflammatory bowel disease (IBD) patients, and vice versa. This emphasizes the potential advantages of including dental professionals in the multi-disciplinary treatment teams of IBD patients.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)