Article
Multidisciplinary Sciences
Kazuki Nishimoto, Nobuyuki Okahashi, Masaharu Maruyama, Yoshihiro Izumi, Kohta Nakatani, Yuki Ito, Junko Iida, Takeshi Bamba, Fumio Matsuda
Summary: This study investigated the metabolic alterations induced by 4-hydroxytamoxifen (OHT) treatment in MCF-7 breast cancer cells using time-series metabolomics and lipidomics. The results revealed changes in lipid and metabolite profiles, indicating the activation of citrate-to-lipid metabolism. Co-treatment experiments showed that inhibition of ATP-dependent citrate lyase (ACLY) or diacylglycerol O-acyltransferase 1 (DGAT1) ameliorated cell death and reduced mitochondrial membrane potential. These findings suggest the critical role of citrate-to-lipid metabolism in OHT-induced cell death in breast cancer cell lines.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Kanchan Kumari, Sudarshan Kumar, Dillip K. Parida, Sandip K. Mishra
Summary: This study elucidated the global change in proteome profile of tamoxifen-resistant MCF-7 breast cancer cells upon EZH2 knockdown, revealing proteins previously unrecognized for their role in tamoxifen resistance and their association with breast cancer patient survival. Targeting EZH2 or downstream molecules may be helpful in reacquiring sensitivity to tamoxifen in breast cancer.
Article
Pharmacology & Pharmacy
Lorinda van Dyk, Nicolette J. D. Verhoog, Ann Louw
Summary: Synergistic drug combinations have gained popularity in various fields of research, including cancer, and have the potential to lower drug resistance and metastasis associated with current therapies. The combination of SM6Met and 4-OH-Tam shows strong synergistic effects in inhibiting ER+ breast cancer cell proliferation, requiring lower doses of 4-OH-Tam. The combination also displays anti-metastatic potential, suggesting it as a viable alternative for treating ER+ breast cancer metastasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Snehal S. Ashtekar, Neela M. Bhatia
Summary: This study utilized in silico methods to design derivatives of the natural product-based lead scaffold-benzopyran and explored their inhibitory potential in cancer therapy through in silico and in vitro screening. The designed compounds exhibited a high affinity towards estrogen receptor-alpha in breast cancer and showed promising cytotoxicity against ER + breast cancer cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Environmental Sciences
Vijayakumar Gunasekaran, Rathinam Yuvakkumar, Ravi Ganesan, Surya Cholayil Palapetta, Harichandran Gurusamy
Summary: In this study, NBA and ABA were synthesized and evaluated for their cell multiplication inhibition activity against MCF-7 and HeLa cancer cell lines. The results showed that both NBA and ABA exhibited antiproliferative action against these cancer cell lines.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ngoc Bao To, Nguyen-Phuong Truong, Meran Keshawa Ediriweera, Somi Kim Cho
Summary: The combination therapy of pentadecanoic acid and tamoxifen can synergistically suppress the growth of tamoxifen-resistant breast cancer cells with low expression of estrogen receptor alpha (ER-alpha). This treatment not only induces apoptosis and inhibits epithelial-to-mesenchymal transition, but also reverses tamoxifen resistance by re-expressing ER-alpha and suppressing critical survival signal pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Md. Khalid Anwer, Farhat Fatima, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Amer S. Alali, Mohd Abul Kalam, Aws Alshamsan, Musaed Alkholief, Abdul Malik, Alanazi Az, Ramadan Al-shdefat
Summary: This study developed sustained release nanosponges (NSs) of Abemaciclib (AC) and evaluated their properties. The results showed that ACN2 exhibited good sustained release performance and potential cytotoxicity against human breast cancer cells. Additionally, ACN2 demonstrated good stability.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Asefeh Dahmardeh Ghalehno, Hakimeh Abdi, Arad Boustan, Khadijeh Jamialahmadi, Fatemeh Mosaffa
Summary: Cancer endocrine therapy can promote evolutionary dynamics and lead to changes in gene expression in tumor cells, as demonstrated by the resistance induction to tamoxifen (TAM) in ER+ MCF-7 breast cancer cells. This resistance resulted in increased expression and activity of the ABCG2 pump, and also led to cross-resistance to mitoxantrone (MX), a known ABCG2 substrate. These findings were consistent in both cell lines and tumor tissues from TAM-resistant patients, highlighting the importance of considering ABCG2-mediated cross-resistance when choosing sequential therapies for TAM-resistant patients.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi
Summary: In this study, folate-conjugated chitosan nanoparticles (F-CS-NPs) were developed as a delivery system for alpha-mangostin (AM) to enhance its cytotoxicity to cancer cells. The use of F-CS-NPs significantly improved the cytotoxicity of AM against MCF-7 breast cancer cells.
Article
Chemistry, Multidisciplinary
Rija Abaid, Maria Malik, Muhammad Aamir Iqbal, Mariam Malik, Zubeda Shahwani, Taha Zaid Ali, Kareem Morsy, Rey Y. Capangpangan, Arnold C. Alguno, Jeong Ryeol Choi
Summary: The unique consequence of green synthesis is the release of chemicals from the mediator plant that act as reducing and stabilizing agents. In this study, silver nanoparticles were synthesized using the fruit pulp and leaf essences of Cassia fistula via green synthesis. The nanoparticles were formed through reduction caused by the reaction between plant essences and the precursor solution. The resulting biosynthesized silver nanoparticles were analyzed for their structure, optical properties, and crystalline behavior using scanning electron microscopy, UV-vis spectroscopy, and X-ray diffraction techniques. The silver nanoparticles exhibited absorption peaks at 401 and 397 nm, corresponding to optical energy gaps of 2.12 and 2.58 eV, and had spherical shapes with diameters ranging from 12-20 and 50-80 nm for the fruit and leaf extracts, respectively. These silver nanoparticles, along with the green synthesis technique, have various applications in the biomedical field, particularly as strong anti-tumor agents for MCF-7 breast cancer cell lines in order to inhibit cell growth rate based on their concentrations.
Article
Engineering, Electrical & Electronic
Ankush Kumar Tangra, Gurmeet Singh
Summary: Biocompatible KFeO2 superparamagnetic nanoparticles were synthesized and characterized for their structure, morphology, magnetic properties, and toxicity. The nanoparticles exhibited a high cell viability and superparamagnetic behavior, with an average particle size of 13 nm and an orthorhombic crystal structure. The study also presented factors affecting nanoparticle toxicity and their incorporation and degradation mechanisms.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Oncology
Jose Adria-Cebrian, Sandra Guaita-Esteruelas, Eric W. -F. Lam, Marta Rodriguez-Balada, Jordi Capellades, Josefa Girona, Ana Maria Jimenez-Santamaria, Oscar Yanes, Luis Masana, Josep Guma
Summary: This study demonstrates the importance of tumor microenvironment crosstalk, the crucial role of lipid transfer between adipose tissue and cancer cells, and the specific lipid signature of each breast cancer subtype. Different breast cancer cell lines metabolize lipids in different ways, with drug resistant cells showing a metabolic pattern more similar to triple negative breast cancer cells. Understanding these lipid patterns may be helpful in breast cancer diagnosis and developing targeted treatments.
Article
Biochemistry & Molecular Biology
Akhil Behringer, Darko Stoimenovski, Martin Porsch, Katrin Hoffmann, Gerhard Behre, Ivo Grosse, Thomas Kalinski, Johannes Haybaeck, Norbert Nass
Summary: This study found a correlation between miRNA and eIFs expression in tamoxifen-adapted breast cancer cells. miR-1972 contributes to the orchestration of gene expression and physiological consequences of tamoxifen adaption. Transfection with a miR-1972 mimic can reverse tamoxifen-induced gene expression and affect cell proliferation in MCF-7 cells.
Article
Biology
Hareth Y. Shujaa Edin, Nagi A. AL-Haj, Abdullah Rasedee, Noorjahan Banu Alitheen, Arifah Abdul Kadir, Chee Wun How, Heshu Sulaiman Rahman, Hussah Abdullah AL-Shwyeh
Summary: The combination treatment of rHuEPO and tamoxifen significantly increased apoptosis in spheroid MCF-7 cells, primarily due to the antiproliferative effect of tamoxifen. The combination treatment also altered the cell cycle distribution of MCF-7 cells, increasing the percentage in the SubG0/G1 phase and decreasing those in the G2+M and S phases.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Hatice Alkan, Ibrahim Hakki Cigerci, Muhammad Muddassir Ali, Omer Hazman, Recep Liman, Florica Cola, Elena Bonciu
Summary: This study evaluated the cytotoxic and genotoxic effects of biosynthesized silver nanoparticles on breast cancer and umbilical vein endothelial cells. The results showed that the synthesized silver nanoparticles exhibited cytotoxic and genotoxic effects on breast cancer cells, but had no significant effects on normal cells.
Article
Chemistry, Multidisciplinary
Bhabani Sankar Satapathy, Biswajit Mukherjee, Rinku Baishya, Mita Chatterjee Debnath, Niladri Shekhar Dey, Ruma Maji
Article
Biochemistry & Molecular Biology
Biswajit Mukherjee, Surajit Das, Samrat Chakraborty, Bhabani Sankar Satapathy, Pranab Jyoti Das, Laboni Mondal, Chowdhury Mobaswar Hossain, Niladri Shekhar Dey, Anumita Chaudhury
CURRENT DRUG METABOLISM
(2014)
Article
Nanoscience & Nanotechnology
Ruma Maji, Niladri Shekhar Dey, Bhabani Sankar Satapathy, Biswajit Mukherjee, Subhasish Mondal
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2014)
Article
Materials Science, Multidisciplinary
Jnanranjan Panda, Bhabani Sankar Satapathy, Sumit Majumder, Ratan Sarkar, Biswajit Mukherjee, Bharati Tudu
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2019)
Article
Chemistry, Applied
Jnanranjan Panda, Bhabani Sankar Satapathy, Bidisha Mandal, Ramkrishna Sen, Biswajit Mukherjee, Ratan Sarkar, Bharati Tudu
Summary: The study successfully developed a biocompatible cobalt ferrite nanodrug formulation for the specific delivery of docetaxel to breast cancer cells, demonstrating sustained release and effective internalization in breast cancer cells.
JOURNAL OF MICROENCAPSULATION
(2021)
Article
Chemistry, Multidisciplinary
Bhabani Sankar Satapathy, Ladi Alik Kumar, Gurudutta Pattnaik, Binapani Barik
Summary: The study aimed to improve the delivery of lomustine to brain tumor cells using lipid-based nanostructures, and experimental results showed potential anti-cancer effects. The selected LNLs demonstrated improved pharmacokinetic profiles in blood and brain in experimental mouse models, indicating potential for future clinical translation.
ACTA CHIMICA SLOVENICA
(2021)
Article
Endocrinology & Metabolism
Biswajit Mukherjee, Sanchari Bhattacharya, Samrat Chakraborty, Bhabani Sankar Satapathy, Niladri Shekhar Dey, Tapan Kumar Shaw
CURRENT DIABETES REVIEWS
(2015)
Article
Biochemistry & Molecular Biology
Biswajit Mukherjee, Bhabani S. Satapathy, Laboni Mondal, Niladri S. Dey, Ruma Maji
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2013)