Trilateral Relationship: Ascaris, Microbiota, and Host Cells

Ascariasis is a globally spread intestinal nematode infection of humans and a considerable concern in pig husbandry. Ascaris accomplishes a complex body migration from the intestine via the liver and lung before returning to the intestine. Tissue migration and the habitat shared with a complex microbial community pose the question of how the nematode interacts with microbes and host cells from various tissues. This review addresses the current knowledge of the trilateral relationship between Ascaris, its microbial environment, and host cells, and discusses novel approaches targeting these interactions to combat this widespread infection of livestock and man.

Automated summary

Ascariasis is a globally spread intestinal nematode infection that poses a significant threat to humans and pig husbandry. The complex body migration of Ascaris involves interactions with host cells and a microbial environment, highlighting the importance of research on this trilateral relationship. Understanding these interactions can lead to novel approaches to combat this widespread infection.