Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 45, Issue 9, Pages 794-805Publisher
CELL PRESS
DOI: 10.1016/j.tibs.2020.05.007
Keywords
-
Categories
Funding
- Portuguese Foundation for Science and Technology (FCT) [POCI-01-0145-FEDER031378, POCI-01-0145-FEDER-016630, POCI-01-0145-FEDER-031238, CEECIND/03747/2017, SFRH/BD/137851/2018, SFRH/BD/146703/2019, UIDB/04501/2020]
- FEDER/FNR component
- CCDRC
- FEDER [CENTRO-01-0145-FEDER-000003]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/146703/2019, SFRH/BD/137851/2018] Funding Source: FCT
Ask authors/readers for more resources
Viruses rely on the host cell translation machinery for efficient synthesis of their own proteins. Emerging evidence highlights different roles for host transfer RNAs (tRNAs) in the process of virus replication. For instance, different RNA viruses manipulate host tRNA pools to favor viral protein translation. Interestingly, specific host tRNAs are used as reverse transcription primers and are packaged into retroviral virions. Recent data also demonstrate the formation of tRNA-derived fragments (tRFs) upon infection to facilitate viral replication. Here, we comprehensively discuss how RNA viruses exploit distinct aspects of the host tRNA biology for their benefit. In light of the recent advances in the field, we propose that host tRNA-related pathways and mechanisms represent promising cellular targets for the development of novel antiviral strategies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available