Challenges and strategies of matrix effects using chromatography-mass spectrometry: An overview from research versus regulatory viewpoints

Title
Challenges and strategies of matrix effects using chromatography-mass spectrometry: An overview from research versus regulatory viewpoints
Authors
Keywords
Method validation, matrix effects, internal standard calibration, matrix-matched calibration, standard addition calibration, ionization, signal suppression or enhancement
Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume -, Issue -, Pages 116068
Publisher
Elsevier BV
Online
2020-10-10
DOI
10.1016/j.trac.2020.116068

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