Article
Surgery
Laura T. Boitano, Emily Y. Fan, Allison S. Crawford, Adam Tanious, Douglas Jones, Jessica P. Simons, Andres Schanzer
Summary: PAD is associated with worse survival following open infrarenal AAA repair. This study found that PAD and sex have an impact on outcomes following the repair. Female PAD patients had nearly four times the odds of perioperative mortality compared with men without PAD.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Immunology
Mingxuan Chi, Kuai Ma, Yunlong Li, Min Quan, Zhongyu Han, Zhaolun Ding, Xin Liang, Qinxiu Zhang, Linjiang Song, Chi Liu
Summary: Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by multiple immunoregulatory abnormalities that lead to damage to various tissues and organs. Researchers have identified aberrant expression of miRNAs in SLE patients, which may be associated with abnormal immune responses and disease progression in SLE.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Huoying Cai, Baihong Pan, Jie Xu, Shuai Liu, Lei Wang, Kemin Wu, Pu Yang, Jianhua Huang, Wei Wang
Summary: There are significant differences in clinical and serum profiles between peripheral artery disease (PAD) and abdominal aortic aneurysm (AAA). D-dimer (>0.675 mg/L) is a reliable biomarker for predicting AAA in PAD patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Caitlin W. Hicks, Ada Al-Qunaibet, Ning Ding, Lucia Kwak, Aaron R. Folsom, Hirofumi Tanaka, Thomas Mosley, Lynne E. Wagenknecht, Weihong Tang, Gerardo Heiss, Kunihiro Matsushita
Summary: The study found that both symptomatic and asymptomatic peripheral artery disease are associated with an elevated risk of abdominal aortic aneurysm. The findings suggest the need for screening asymptomatic PAD patients for AAA, in addition to current recommendations for screening symptomatic PAD patients.
Review
Biochemistry & Molecular Biology
Maria J. Pajares, Ester Alemany-Cosme, Saioa Goni, Eva Bandres, Cora Palanca-Ballester, Juan Sandoval
Summary: Cancer is a complex disease involving alterations in multiple processes, with genetic and epigenetic features as core factors. Non-coding RNAs (ncRNAs), particularly microRNAs, play a key role in cancer initiation and progression by controlling cellular processes like proliferation, differentiation, and apoptosis. The expression of microRNAs is regulated by other epigenetic factors, resulting in aberrant expression patterns in cancer, and evaluating aberrant microRNA landscape holds promise for cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
John Anagnostakos, Brajesh K. Lal
Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Genetics & Heredity
Man Li, Litao Bao, Ping Zhu, Shuxia Wang
Summary: This study investigated the impact of metformin on the epigenetic age in subjects with type 2 diabetes mellitus (DM). The results showed an association between metformin intake and slower epigenetic aging.
FRONTIERS IN GENETICS
(2022)
Article
Surgery
Shivshankar Thanigaimani, Vikram Iyer, John Bingley, Daniel Browne, James Phie, Denise Doolan, Jonathan Golledge
Summary: This study examined the association between serum microRNAs (miRNAs) and diagnosis and growth of abdominal aortic aneurysm (AAA), and tested their diagnostic and prognostic value. The expression levels of 800 miRNA tags were assessed in AAA patients, healthy controls, and patients with peripheral artery disease (PAD). The miRNAs let-7b-5p and miR-548n improved the ability to diagnose AAA, but none of the miRNAs had independent prognostic value in predicting AAA growth.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Dagmara Adamska-Tomaszewska, Piotr Kocelak, Aleksander J. Owczarek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
Summary: The study found that the frequency of vitamin D (VD) deficiency in outpatients with abdominal aortic aneurysms (AAA) is not higher than in those with peripheral artery disease (PAD). Past stroke episodes are associated with an increased occurrence of VD deficiency in both AAA and PAD patients, besides sun exposure and diet.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Jacek Rysz, Beata Franczyk, Magdalena Rysz-Gorzynska, Anna Gluba-Brzozka
Summary: The modifications in genomic DNA methylation play a crucial role in regulating normal and pathological cellular processes, and are associated with the development of diseases such as atherogenesis, cancers, and chronic kidney disease (CKD). Altered DNA methylation can affect the progression of renal disease by modulating the expression of pro-inflammatory and pro-fibrotic genes, as well as genes essential for kidney development and function. Understanding the genetic-epigenetic profile is important for unraveling the processes underlying CKD development and improving the ability to identify individuals at risk and choose appropriate disease management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Megan Lee, Matthew D. Pichert, Andy T. Tran, Awais Farooq, Jan M. Heyligers, Jean-Paul P. M. de Vries, John A. Spertus, Raul J. Guzman, Merrill Thomas, Carlos I. Mena-Hurtado, Kim G. Smolderen
Summary: This study investigates whether patients with peripheral artery disease (PAD) are being screened for abdominal aortic aneurysms (AAA). The results show that approximately 68% of patients were screened for AAA, with about 6.1% having AAA. While there were no significant differences in AAA screening rates between different countries, there was a large variation between different healthcare institutions, highlighting the need for more efforts in guideline implementation and evidence-building for high-risk populations, including patients with PAD.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nina Sopel, Janina Muller-Deile
Summary: Epigenetic modifications can alter gene expression through various mechanisms such as DNA methylation and histone modifications. This review focuses on the role of epigenetic changes in gene regulation, particularly in renal diseases, and highlights the potential of using the zebrafish model for studying epigenetics and discovering novel therapeutic targets. The zebrafish model offers a high-throughput screening tool to identify epigenetic alterations contributing to disease and test new substances for changing epigenetic signatures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Gillian England-Mason, Sarah M. Merrill, Nicole Gladish, Sarah R. Moore, Gerald F. Giesbrecht, Nicole Letourneau, Julia L. MacIsaac, Amy M. MacDonald, David W. Kinniburgh, Anne-Louise Ponsonby, Richard Saffery, Jonathan W. Martin, Michael S. Kobor, Deborah Dewey
Summary: Prenatal exposure to phthalates is associated with DNA methylation variations in infants, including genes related to endocrine hormone activity, immune pathways, DNA damage, and neurodevelopment. Further research is needed to confirm these associations in larger samples and across different tissues.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Genetics & Heredity
Kangjie Wang, Qinghui Kan, Yanchen Ye, Jiachong Qiu, Lin Huang, Ridong Wu, Chen Yao
Summary: This study highlights the strong correlation between m6A methylation modification and immune infiltration in AAA, which may promote the progression of the disease. The researchers constructed an individualized m6Ascore model to provide evidence for personalized treatments in the future.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Karol P. P. Ruszel, Daniel P. P. Zalewski, Andrzej Stepniewski, Dariusz Galkowski, Jacek Bogucki, Marcin Feldo, Bartosz J. J. Plachno, Janusz Kocki, Anna Bogucka-Kocka
Summary: Vascular diseases are leading causes of death and morbidity, and there is a need for new biomarkers for monitoring and potential treatment. Next-generation sequencing of mRNA revealed significant differences in the expression of DNA repair-related genes in abdominal aortic aneurysm, chronic venous disease, and lower extremity artery disease, which could be utilized for the design of new biomarkers or therapies associated with these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Aaron Drovandi, Shannon Wong, Leonard Seng, Benjamin Crowley, Chanika Alahakoon, Jasmin Banwait, Malindu E. E. Fernando, Jonathan Golledge
Summary: This overview examines the effectiveness, stakeholder perceptions, and cost-effectiveness of remotely delivered healthcare for diabetes-related foot disease (DFD). The study found that remotely delivered healthcare for DFD is well received by patients and clinicians, but its effectiveness remains unclear. More high-quality trials are needed to evaluate the risks and benefits of remotely delivered DFD management.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yutang Wang, Yan Fang, Dianna J. Magliano, Fadi J. Charchar, Christopher G. Sobey, Grant R. Drummond, Jonathan Golledge
Summary: This study investigates the association between fasting triglycerides and cardiovascular disease mortality. The results show that higher triglyceride levels are associated with an increased risk of CVD mortality in patients with diabetes, but not in those without diabetes. This suggests that future treatments targeting triglyceride reduction should focus on patients with diabetes.
CARDIOVASCULAR RESEARCH
(2023)
Article
Surgery
Dylan R. Morris, Tejas P. Singh, Tahmid Zaman, Ramesh Velu, Francis Quigley, Jason Jenkins, Jonathan Golledge
Summary: This cohort study showed no significant differences in stroke rates among patients with different presentations of carotid artery stenosis.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Letter
Surgery
Jordan Harding, Rebecca Evans, Jenna Pinchbeck, Jonathan Golledge
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Review
Surgery
Chanika Alahakoon, Shivshankar Thanigaimani, Leonard Seng, Malindu Fernando, Peter Lazzarini, Jonathan Golledge
Summary: This study aimed to systematically review the incidence and risk factors for 30-day readmission to hospital following an index admission to treat diabetes-related foot disease (DFD). Meta-analysis found that approximately one-fifth of DFD patients were readmitted to hospital within 30 days, of which about half were to treat DFD. Risk factors for readmission included female gender, peripheral neuropathy, lack of private health insurance, and coronary artery disease.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Chanika Alahakoon, Tejas P. Singh, Charith Galappaththy, James Charles, Malindu Fernando, Peter Lazzarini, Joseph Moxon, Jonathan Golledge
Summary: This study aimed to identify the rates and predictive factors for hospital re-admission among patients with diabetes related foot disease (DFD). The results showed that over 50% of patients were re-admitted within one year, and patients with absent pedal pulses and loss of protective sensation (LOPS) were twice as likely to be re-admitted.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Review
Biochemistry & Molecular Biology
Chinmay Sharma, Tejas P. Singh, Shivshankar Thanigaimani, Domenico Nastasi, Jonathan Golledge
Summary: This study assessed the incidence rate of major adverse cardiovascular events (MACE) in patients with unrepaired abdominal aortic aneurysm (AAA) and their association with modifiable risk factors (diabetes, hypertension) and medication use (aspirin, statins). The study found a high incidence of cardiovascular death, myocardial infarction (MI), and stroke in patients with unrepaired AAA, but the prescription rate of preventive medication was suboptimal. Therefore, greater emphasis should be placed on secondary prevention measures in this population.
Review
Cardiac & Cardiovascular Systems
Mary M. Kavurma, Lauren Boccanfuso, Carina Cutmore, Freda Passam, Sanjay Patel, Annemarie Hennessy, Jacky Loa, Gemma A. Figtree, Jonathan Golledge, David A. Robinson, Sarah Aitken
Summary: Peripheral artery disease (PAD) is a significant social and economic burden with gender disparities. Women may have equal or higher prevalence of PAD and experience worse clinical outcomes. The underlying reasons for these gender inequalities in PAD are unclear. A scoping review using the World Health Organization model was conducted to explore the complex factors contributing to gender-related inequities in the diagnosis, treatment, and management of PAD. Gaps in knowledge were identified, and recommendations for addressing these inequalities were discussed.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Endocrinology & Metabolism
Benjamin Crowley, Aaron Drovandi, Leonard Seng, Malindu E. Fernando, Diane Ross, Jonathan Golledge
Summary: The purpose of this study was to understand patients' perspectives on the impact and prevention of diabetes-related foot disease (DFD). A survey was conducted among patients with a history of DFD, and the results showed that foot ulcers were the most common complication, with a significant number of patients having been admitted to the hospital or undergone amputation due to DFD. The study also revealed varying perceptions on the effect of DFD on health, the importance of offloading footwear for prevention, and mixed views on telehealth.
SCIENCE OF DIABETES SELF-MANAGEMENT AND CARE
(2023)
Article
Biochemistry & Molecular Biology
Yutang Wang, Owen Sargisson, Dinh Tam Nguyen, Ketura Parker, Stephan J. R. Pyke, Ahmed Alramahi, Liam Thihlum, Yan Fang, Morgan E. Wallace, Stuart P. Berzins, Ernesto Oqueli, Dianna J. Magliano, Jonathan Golledge
Summary: The study found that hydralazine inhibits the formation and rupture of AAA by suppressing inflammatory gene expression and apoptosis, providing new insights for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shannon A. Wong, Aaron Drovandi, Rhondda Jones, Jonathan Golledge
Summary: This systematic review analyzed the effects of dietary upregulators of nitric oxide (NO) on walking distance and quality of life in patients with peripheral artery disease (PAD) through randomized controlled trials (RCTs). Thirty-four RCTs involving 3472 participants were included. The findings suggest that dietary supplements, particularly antioxidants, can improve initial claudication distance in patients with PAD. However, larger and higher quality RCTs are needed to further explore the benefits and risks of these treatments.
Article
Materials Science, Multidisciplinary
Jesus Romo-Rico, Richard Bright, Smriti Murali Krishna, Krasimir Vasilev, Jonathan Golledge, Mohan V. Jacob
Summary: In this research, graphene (Gr) was deposited on a medical-grade cobalt-chromium (CoCr) alloy surface using Origanum vulgare as a precursor material. The biocompatibility and antibacterial properties of CoCr-Gr were investigated. The results suggest that CoCr-Gr could be a potential antibacterial coating material for implantable devices.
Article
Environmental Sciences
Joshua S. Jones, Lee Nedkoff, Jane S. Heyworth, Osvaldo P. Almeida, Leon Flicker, Jonathan Golledge, Graeme J. Hankey, Elizabeth H. Lim, Mark Nieuwenhuijsen, Bu B. Yeap, Michelle L. Trevenen
Summary: This study aimed to determine the dose-response relationship between long-term exposure to low-concentration PM2.5 air pollution and incident ischemic heart disease (IHD), heart failure (HF), and atrial fibrillation (AF) in older men. The results showed a trend of increased incidence of IHD, HF, and AF, but none were statistically significant under low-concentration PM2.5 air pollution exposure.
ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Stephanie Y. Tan, S. A. Paul Chubb, Leon Flicker, Osvaldo P. Almeida, Jonathan Golledge, Graeme J. Hankey, Bu B. Yeap
Summary: The study aimed to assess the prevalence and incidence of subclinical thyroid dysfunction in older men. The results showed that one-fifth of initially euthyroid men developed subclinical or overt hypothyroidism, and age and higher baseline thyroid stimulating hormone (TSH) levels predicted this outcome.
CLINICAL ENDOCRINOLOGY
(2023)
Correction
Cardiac & Cardiovascular Systems
J. Golledge, L. Yip, A. Venn, J. Moxon
