Methods of Synthesis of Remdesivir, Favipiravir, Hydroxychloroquine, and Chloroquine: Four Small Molecules Repurposed for Clinical Trials during the Covid-19 Pandemic

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Chloroquine and hydroxychloroquine as available weapons to fight COVID-19

(2020) Philippe Colson et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

(2020) Chih-Cheng Lai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Chloroquine for the 2019 novel coronavirus SARS-CoV-2

(2020) Philippe Colson et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

(2020) Calvin J Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

More than 80 clinical trials launch to test coronavirus treatments

(2020) Amy Maxmen   NATURE

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

(2020) Jianjun Gao et al.   BioScience Trends

Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study

(2020) Qingxian Cai et al.   Engineering

Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge

(2019) Michael K. Lo et al.   Science Translational Medicine

High-yielding continuous-flow synthesis of antimalarial drug hydroxychloroquine

(2018) Eric Yu et al.   Beilstein Journal of Organic Chemistry

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

(2017) Dustin Siegel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

(2016) Joshua R. Dunetz et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases

(2015) K. D. Rainsford et al.   INFLAMMOPHARMACOLOGY

Wittig Reactions of Trialkylphosphine-derived Ylides: New Directions and Applications in Organic Synthesis

(2014) James McNulty et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Reductive hydroxyalkylation/alkylation of amines with lactones/esters

(2012) Yu-Huang Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Catalytic Oxidation of Alcohols to Corresponding Aldehydes or Ketones with TEMPO-Mediated Iodosobenzene in Water in the Presence of a Surfactant

(2010) Chenjie Zhu et al.   SYNTHETIC COMMUNICATIONS