Article
Surgery
Michael O'Laughlin, Jorge Cornejo, Alba Zevallos, Alisa Coker, Michael Schweitzer, Gina Adrales, Christina Li, Raul Sebastian
Summary: Background: The rates of secondary bariatric surgery have increased, with sleeve gastrectomy to gastric bypass conversion being the most common. This study evaluates the outcomes of this conversion compared to primary Roux-en-Y gastric bypass (RYGB) surgery using MBSAQIP data. Methods: The study analyzed the data of patients who underwent sleeve gastrectomy to RYGB conversion and primary laparoscopic RYGB, matching them based on preoperative characteristics. Results: The analysis showed that the conversion from sleeve gastrectomy to RYGB was associated with higher readmissions, interventions, conversion to open surgery, longer hospital stay, and longer operative time compared to primary RYGB. However, there were no significant differences in mortality or rates of bariatric complications. Conclusion: The study concludes that conversion from sleeve gastrectomy to RYGB is a safe and feasible procedure with reasonable outcomes compared to primary RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Marta Guimaraes, Catarina Osorio, Diogo Silva, Rui F. Almeida, Antonio Reis, Samuel Cardoso, Sofia S. Pereira, Mariana P. Monteiro, Mario Nora
Summary: The study evaluated the long-term efficacy of Roux-en-Y Gastric Bypass (RYGB) surgery by assessing weight loss and comorbidity improvement in patients 10 years or more after the surgery. Results showed a significant decrease in body mass index (BMI) and successful comorbidity remission. Although a small proportion of patients required revision surgery for weight loss failure, RYGB was confirmed as an effective primary bariatric intervention.
Article
Surgery
Madelief Wijdeveld, Nienke van Olst, Eduard W. J. van der Vossen, Maurits de Brauw, Yair I. Z. Acherman, Marcus C. de Goffau, Victor E. A. Gerdes, Max Nieuwdorp
Summary: This study investigated the microbial predisposition before Roux-en-Y gastric bypass surgery (RYGB) that is associated with gastrointestinal (GI) symptoms during follow-up. The study found that changes in the intestinal microbiome after surgery are related to postoperative GI symptoms.
Article
Medicine, General & Internal
Chunlan Zhang, Jingjing Zhang, Zhiguang Zhou
Summary: The fasting bile acid levels, especially 12a-hydroxylated bile acid levels, were found to increase significantly after Roux-en-Y gastric bypass (RYGB). However, no significant changes in fasting bile acid levels were observed following sleeve gastrectomy (SG).
Article
Surgery
Mauricio Gonzalez-Urquijo, David E. Hinojosa-Gonzalez, Ale Gibran Alam Gidi, Sofia Hurtado Arellano, Eduardo Flores-Villalba, Javier Rojas-Mendez
Summary: Revisional gastric bypass surgery for failed gastric banding patients showed higher complication rates compared to primary RYGB. Despite a greater postoperative weight increase in the revisional group at 12-month follow-up, the difference was not statistically significant. Changes in weight and BMI did not differ significantly between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Medicine, General & Internal
Marita Salame, Noura Jawhar, Amanda Belluzzi, Mohammad Al-Kordi, Andrew C. Storm, Barham K. Abu Dayyeh, Omar M. Ghanem
Summary: Marginal ulcers (MU) are a potential complication following Roux-en-Y gastric bypass (RYGB) surgery, with an average prevalence of 4.6%. Early identification and prompt intervention are crucial to prevent further complications. MU is a complex condition influenced by factors such as smoking, Helicobacter pylori infection, NSAID use, and pouch size. Diagnosis is typically made through endoscopy, and treatment involves modifying risk factors and medical therapy with proton pump inhibitors. Surgical intervention may be necessary for complicated ulcers, while endoscopic procedures and vagotomy may be considered for recurrent or challenging cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Fu Chen, Yong Zhou, Zhiyuan Wu, Yunze Li, Wenlong Zhou, Yong Wang
Summary: This study identified global gene expression changes in NASH patients' livers before and after RYGB surgery using bioinformatic methods. The findings demonstrate the significant improvement of NASH after RYGB surgery, with key pathways and hub genes involved in the process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nele Steenackers, Tim Vanuytsel, Patrick Augustijns, Ellen Deleus, Wies Deckers, Christophe M. Deroose, Gwen Falony, Matthias Lannoo, Ann Mertens, Raf Mols, Roman Vangoitsenhoven, Lucas Wauters, Bart Van der Schueren, Christophe Matthys
Summary: This study investigated the effects of sleeve gastrectomy and Roux-en-Y gastric bypass on gastrointestinal motility, pH, and bile acid concentration. The findings showed that both surgeries increased pouch emptying and gastric emptying, and also led to higher pH levels and bile acid concentrations in the intestines. These results highlight the significant impact of these surgeries on gastrointestinal physiology.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Nutrition & Dietetics
Mohammed K. Hankir, Laura Rotzinger, Arno Nordbeck, Caroline Corteville, Ulrich Dischinger, Juna-Lisa Knop, Annett Hoffmann, Christoph Otto, Florian Seyfried
Summary: Sensitization to the adipokine leptin may not be necessary for the normalization of energy and glucose homeostasis associated with RYGB surgery, but its potential contribution to improvements in liver health postoperatively deserves further investigation.
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: Transoral gastric outlet reduction (TORe) is a safe and effective treatment for post-prandial hypoglycemia and weight regain after Roux-en-Y gastric bypass (RYGB) in patients with symptoms refractory to medications and dietary changes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: TORe is a safe and effective treatment for patients with refractory symptoms of post-prandial hypoglycemia and weight regain after RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Urska Novljan, Tadeja Pintar
Summary: This study evaluated the incidence of small intestinal bacterial overgrowth (SIBO) after bariatric bypass procedures and its connection with symptoms, comorbidities, and liver pathology. The results showed a alarmingly high incidence of SIBO after bariatric surgery and suggested that diagnosis cannot be based solely on specific symptoms. The study also found a correlation between SIBO and reduced response to low molecular weight heparin (LMWH) application.
Article
Surgery
Russell D. Dolan, Jason Baker, Kimberly Harer, Allen Lee, William Hasler, Richard Saad, Allison R. Schulman
Summary: This study suggests that patients with RYGB anatomy have a higher frequency of SIBO and are more likely to report specific GI symptoms compared to patients with native anatomy, indicating the need for early evaluation.
Article
Endocrinology & Metabolism
Qinghe Meng, Derek M. Culnan, Tamer Ahmed, Mingjie Sun, Robert N. Cooney
Summary: Roux-en-Y gastric bypass (RYGB) has significant effects on intestinal GLP-1 release and glucose transport in obese rats, potentially improving glycemic control by increasing GRP119 and FFAR2/3.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Ahmad Tarhini, Claire Rives-Lange, Anne-Sophie Jannot, Clement Baratte, Nathan Beaupel, Vincent Guillet, Sylvia Krivan, Maude Le Gall, Claire Carette, Sebastien Czernichow, Jean-Marc Chevallier, Tigran Poghosyan
Summary: This study compares the efficacy of long biliopancreatic limb Roux-en-Y gastric bypass (L-BPL-RYGB) and traditional short biliopancreatic limb Roux-en-Y gastric bypass (S-BPL-RYGB) in treating refractory gastroesophageal reflux disease (GERD) symptoms. The results show that L-BPL-RYGB is more appropriate for patients with biliary reflux (BR), while S-BPL-RYGB is preferred for patients with acid reflux (AR).
Letter
Endocrinology & Metabolism
Erika B. Parente, Stefan Mutter, Lena M. Thorn, Valma Harjutsalo, Per-Henrik Groop
Article
Endocrinology & Metabolism
Patrik Smidtslund, Fanny Jansson Sigfrids, Anni Ylinen, Nina Elonen, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn
Summary: This study aims to investigate the prognosis after a first-ever myocardial infarction (MI) in individuals with type 1 diabetes and how different MI- and diabetes-related factors affect the prognosis and risk of secondary cardiovascular events. The study found that individuals with type 1 diabetes have a high cardiovascular and diabetes-related mortality after their first-ever MI, and poor kidney function is associated with high mortality and excessive risk of secondary cardiovascular events.
Article
Cardiac & Cardiovascular Systems
Anniina Tynjala, Valma Harjutsalo, Fanny Jansson Sigfrids, Per-Henrik Groop, Daniel Gordin
Summary: This study investigated the association between long-term glycemic variability and arterial stiffness in patients with type 1 diabetes. The results showed that the variability of HbA1c was significantly correlated with arterial stiffness. Importantly, this association was independent of the HbA1c mean.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Erika B. Parente, Aila J. Ahola, Anmol Kumar, Markku Lehto, Per-Henrik Groop
Summary: The study found that there is an association between fibroblast growth factor 23 (FGF23) and body composition in patients with type 1 diabetes, but this relationship varies depending on the albuminuria stage. Specifically, in patients with microalbuminuria, FGF23 was positively associated with total fat, visceral fat, and android fat tissues, while negatively associated with lean tissue; however, FGF23 was not associated with body composition in patients with normal albumin excretion rate, macroalbuminuria, and controls.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Minna Harsunen, Jani Haukka, Valma Harjutsalo, Nina Mars, Anna Syreeni, Taina Harkonen, Annemari Karajaemaki, Jorma Ilonen, Mikael Knip, Niina Sandholm, Paivi Johanna Miettinen, Per-Henrik Groop, Tiinamaija Tuomi
Summary: Contrary to the presumption that type 1 diabetes leads to an absolute insulin deficiency, this study found that many individuals with type 1 diabetes still have circulating C-peptide years after diagnosis. The study also identified the correlation between age at diagnosis and decline in C-peptide secretion, as well as the association between polygenic risk scores, clinical factors, and random serum C-peptide concentrations.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ina Lampenius, Valma Harjutsalo, Erika Parente, Per-Henrik Groop
Summary: Alcohol consumption is linearly associated with visceral fat mass percentage in adults with type 1 diabetes, regardless of sex, whereas the association with body fat mass percentage is sex-dependent.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Editorial Material
Endocrinology & Metabolism
Roberto Pecoits-Filho, Beatriz Yanez Jimenez, Gloria E. Ashuntantang, Federica de Giorgi, Salvatore De Cosmo, Per-Henrik Groop, Adrien Liew, Anne Hradsky, Roberto Pontremoli, Laura Sola, Antonio Ceriello
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Hiddo J. L. Heerspink, Andreas L. Birkenfeld, David Z. I. Cherney, Helen M. Colhoun, Linong Ji, Chantal Mathieu, Per-Henrik Groop, Richard E. Pratley, Sylvia E. Rosas, Peter Rossing, Jay S. Skyler, Katherine R. Tuttle, Robert Lawatscheck, Charlie Scott, Robert Edfors, Markus F. Scheerer, Peter Kolkhof, Janet B. McGill
Summary: This study aims to evaluate the efficacy and safety of Finerenone in type 1 diabetes and chronic kidney disease (CKD). Finerenone could potentially become the first registered treatment for CKD associated with type 1 diabetes in almost 30 years.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Cardiac & Cardiovascular Systems
Francesco Cosentino, Subodh Verma, Philip Ambery, Marianne Bach Treppendahl, Martin van Eickels, Stefan D. Anker, Michele Cecchini, Paola Fioretto, Per-Henrik Groop, David Hess, Kamlesh Khunti, Carolyn S. P. Lam, Isabelle Richard-Lordereau, Lars H. Lund, Paul McGreavy, Philip N. Newsome, Naveed Sattar, Scott Solomon, Franz Weidinger, Faiez Zannad, Andreas Zeiher
Summary: Metabolic comorbidities are common in cardiorenal disease and are associated with increased risk of poor outcomes of COVID-19 infection. Recognition and treatment of cardiometabolic diseases, as well as improving lifestyle and developing new biomarkers, are essential for prevention and management.
EUROPEAN HEART JOURNAL
(2023)
Article
Multidisciplinary Sciences
Raija Lithovius, Stefan Mutter, Erika B. Parente, Ville-Petteri Makinen, Erkka Valo, Valma Harjutsalo, Per-Henrik Groop
Summary: Effective treatment can prevent kidney complications in women with type 1 diabetes, but there may be underprescription in some cases. Data analysis of prescriptions and their relationship with kidney health can provide insights to optimize treatment.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Anniina Pirttiniemi, Krishna Adeshara, Natalie Happonen, Elisabet Einarsdottir, Shintaro Katayama, Hanne Salmenkari, Sohvi Horkko, Juha Kere, Per-Henrik Groop, Markku Lehto
Summary: Inorganic polyphosphates are bioactive phosphate polymers found in all living organisms, and in mammals, they play a vital role in regulating cellular metabolism, coagulation, and inflammation. Long-chain polyphosphates, particularly P700, can modulate the type I interferon signaling and cytokine secretion in human leukocytes. P700 treatment decreases interferon signaling and subsequent gene expression, while augmenting the secretion of various cytokines. This study demonstrates the extensive modulatory effects of P700 on cytokine signaling, specifically targeting type I interferon signaling in human leukocytes.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Endocrinology & Metabolism
M. I. Eriksson, A. Syreeni, N. Sandholm, E. H. Dahlstrom, D. Gordin, T. Tatlisumak, J. Putaala, Per-Henrik Groop, J. Martola, L. M. Thorn
Summary: This study aimed to evaluate the association between haptoglobin genotype and cerebral small-vessel disease (SVD). The results showed no significant association between haptoglobin genotype and SVD.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Jaakko O. Markkanen, Noora Oikarinen, Markku J. Savolainen, Heta Merikallio, Ville Nyman, Ville Salminen, Teppo Virkkula, Pasi Karppinen, Harri Oinas-Kukkonen, Janne Hukkanen
Summary: This study aimed to investigate the effectiveness of a mobile health behaviour change support system (mHBCSS) as a stand-alone treatment for obesity. The results showed that mHBCSS led to weight reduction and maintenance, with high adherence rates.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Food Science & Technology
Reijo Laatikainen, Markku Lehto, Noora Maekelae-Salmi, Markku Hillilae, Per-Henrik Groop, Hanne Salmenkari
Summary: This study suggests that short-term usage of food-grade carrageenan is safe among people with UC, but further rigorous human studies are needed due to the limitations of the current study.
FOOD & NUTRITION RESEARCH
(2023)
