Review
Materials Science, Multidisciplinary
Zixuan Lu, Aimie Pavia, Achilleas Savva, Loig Kergoat, Roisin M. Owens
Summary: Microelectrode arrays (MEAs) are devices used to record and stimulate biological activity of cells. Organic mixed ionic and electronic conductors (OMIECs) have gained attention as active materials for MEAs due to their advantages over traditional metal-based MEAs. These organic microelectrode arrays offer high signal-to-noise ratio and low electrochemical impedance, making them suitable for various applications in vivo and in vitro.
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2023)
Article
Polymer Science
Dong Hyun Lee, Eun Kwang Lee, Chae Hyun Kim, Hyung Joong Yun, Young-Joon Kim, Hocheon Yoo
Summary: To increase human lifespan, healthcare monitoring devices are crucial. Commercial wet electrodes have high conductivity but pose problems after long-term use. Therefore, we propose a dry electrode that can be reused for an extended period and reliably detects biosignals.
Article
Chemistry, Analytical
Qichao Pan, Qing Wu, Qingsong Sun, Xingyin Zhou, Lei Cheng, Shouyan Zhang, Yupeng Yuan, Zuwei Zhang, Jinyi Ma, Yaopeng Zhang, Bo Zhu
Summary: This study proposes a facile and universal method to fabricate a protein-encapsulated PEDOT:PSS material using chitosan as a crosslinker and bioprotectant. The resulting biosensing interface demonstrates excellent aqueous stability, high bioactivity retention, and is suitable for biosensors with high sensitivity and stability.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Yanping Wang, Zhongji Qu, Wei Wang, Dan Yu
Summary: The study presents a conductive hydrogel using polyvinyl alcohol and carboxymethyl cellulose as the skeleton, with a PEDOT:PSS mixture as the conductive pathway, exhibiting high electrical conductivity and soft moisturizing properties. These hydrogels can replace traditional high-cost electrodes, resembling human tissues and forming a seamless interface with the human body, showing promising application prospects in ECG biosensors.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Applied
Meng Zhang, Yaxuan Wang, Kun Liu, Yang Liu, Ting Xu, Haishun Du, Chuanling Si
Summary: Hydrogels with flexibility, versatility, and high sensitivity are important in wearable sensor design. The preparation of high-performance hydrogel-based sensors that can withstand extreme cold conditions is challenging. This study constructs a novel anti-freezing composite hydrogel based on polyacrylamide (PAM), LiCl, and PEDOT:PSS coated cellulose nanofibrils (PAM/PEDOT:PSS/CNF). The addition of CNF improves the mechanical strength and conductivity of the hydrogel, while LiCl enhances freezing tolerance. The composite hydrogel is used to assemble flexible sensors with high sensitivity for detecting human movements and physiological activities.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Multidisciplinary
Anand Dev Ranjan, Rakesh Sen, Rahul Vaippully, Sumeet Kumar, Soumya Dutta, Basudev Roy, Goutam Dev Mukherjee, Soumyajit Roy, Ayan Banerjee
Summary: The engineering of interfaces is crucial in determining the fundamental properties of matter, and microbubble lithography (MBL) is a method that enables interface engineering. By using MBL to create patterned interfaces of a polymer, the conductivity of the polymer can be greatly enhanced, especially on a flexible PDMS substrate.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Instruments & Instrumentation
Yonghao Liu, Xiang-Chao Sun, Chao Lv, Hong Xia
Summary: By utilizing the bio-friendly PEDOT:PSS-gelatin material, moisture-responsive actuators and generators can be fabricated, showing potential applications in various fields with their green nanoarchitectonics properties.
SMART MATERIALS AND STRUCTURES
(2021)
Review
Polymer Science
Euis Siti Nurazizah, Annisa Aprilia, Risdiana Risdiana, Lusi Safriani
Summary: PEDOT:PSS is commonly used as a counter electrode in dye-sensitized solar cells (DSSC), while PEDOT:Carrageenan has been introduced as an electrolyte. This review provides an overview of the different roles of PEDOT:PSS and PEDOT:Carrageenan in DSSC. It also describes the synthesis process and characteristics of both materials. Overall, PEDOT:PSS functions as a counter electrode by transferring electrons back to the cell and accelerating redox reactions, while PEDOT:Carrageenan as an electrolyte does not effectively regenerate the dye sensitized at the oxidized state, resulting in a lower performance in DSSC.
Article
Materials Science, Paper & Wood
Yanping Wang, Xing Zhong, Wei Wang, Dan Yu
Summary: The study introduces a flexible, low-cost conductive electrode by using cellulose and polyvinyl alcohol as a substrate, assembling with conductive polymer polythiophene. The composite electrode shows good flexibility and stability, capable of clearly monitoring ECG signals.
Article
Chemistry, Multidisciplinary
Ting Li, Jie Yan Cheryl Koh, Akshay Moudgil, Huan Cao, Xihu Wu, Shuai Chen, Kunqi Hou, Abhijith Surendran, Meera Stephen, Cindy Tang, Chongwu Wang, Qi Jie Wang, Chor Yong Tay, Wei Lin Leong
Summary: This study investigates the use of a biocompatible ionic liquid [MTEOA][MeOSO3] as an additive to enhance the performance of PEDOT:PSS-based OECTs for biosensing applications. The PEDOT:PSS/[MTEOA][MeOSO3]-based OECTs show high transconductance, fast response time, and excellent switching cyclical stability. The integration of ion-selective membranes enables selective ion detection, while flexible OECTs are designed for electrocardiography (ECG) signal acquisition, showing robust performance against physical deformation and high-quality signal recording.
Article
Polymer Science
Dania Adila Ahmad Ruzaidi, Mohd Muzamir Mahat, Zarif Mohamed Sofian, Nikman Adli Nor Hashim, Hazwanee Osman, Mohd Azizi Nawawi, Rosmamuhamadani Ramli, Khairil Anuar Jantan, Muhammad Faiz Aizamddin, Hazeeq Hazwan Azman, Yee Hui Robin Chang, Hairul Hisham Hamzah
Summary: This study successfully synthesized PEDOT:PSS hydrogels and characterized the performance of Cs-Gel-Agar porous hydrogels through various analysis methods. The results demonstrated the optimum electrical conductivity of the hydrogels at a 1% PEDOT:PSS mixing ratio.
Article
Engineering, Electrical & Electronic
Xiaojin Luo, Shihang Rao, Hailong Lu, Yue Cui
Summary: This study developed a flexible, low-cost, miniature methane sensor based on PEDOT:PSS coated screen-printed electrochemical electrodes. The presence of methane causes a change in the resistance of the PEDOT:PSS layer, serving as a sensing electrode. The sensor demonstrates fast detection time, excellent sensitivity, wide linear detection range, and stability, making it suitable for applications such as natural gas exploration and methane leak identification.
IEEE ELECTRON DEVICE LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Daniele Testore, Alice Zoso, Galder Kortaberria, Marco Sangermano, Valeria Chiono
Summary: This study developed electroconductive hydrogels with tunable electrical and mechanical properties for tissue engineering applications. The hydrogels were composed of a blend of polyethylene glycol diacrylate (PEGDA) and gelatin, and incorporated poly (3,4-ethylenedioxythiophene):poly (styrene sulfonate) (PEDOT:PSS) for electroactivity. The results showed that the physical properties of the hydrogels could be adjusted by the initial ratio of PEGDA to gelatin, and the addition of PEDOT:PSS improved the electrical properties. In vitro tests demonstrated the cytocompatibility of the hydrogels and suggested their potential for cardiac tissue engineering applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Jonathan Hopkins, Kristina Fidanovski, Lorenzo Travaglini, Daniel Ta, James Hook, Pawel Wagner, Klaudia Wagner, Antonio Lauto, Claudio Cazorla, David Officer, Damia Mawad
Summary: PEDOT-Phos, a new conjugated polymer, shows great promise as a channel material for energy-efficient, bioelectronic devices. It combines a PEDOT backbone with alkyl-protected phosphonate groups, exhibiting efficient operation in aqueous OECTs, long-term stability, and good performance comparable to other PEDOT-based materials.
CHEMISTRY OF MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Lili Jiang, Xiong Lu
Summary: Hydrogel-based supercapacitors, with their high flexibility and multifunctionality, show great potential as energy storage alternatives for portable/wearable electronic devices.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Analytical
Hyo Geun Lee, Wook Choi, Seung Yun Yang, Dong-Ho Kim, Sung-Gyu Park, Min-Young Lee, Ho Sang Jung
Summary: A paper-based surface-enhanced Raman scattering (SERS) substrate was developed for rapid detection of respiratory bacterial DNA, coupled with polymerase chain reaction (PCR). The PCR-coupled SERS method showed enhanced detection capability after 10 amplification cycles, enabling low-cycle amplification and sensitive DNA sensing.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemistry & Molecular Biology
Soo-Eun Sung, Kyung-Ku Kang, Joo-Hee Choi, Si-Joon Lee, KilSoo Kim, Ju-Hyeon Lim, Seung Yun Yang, Seul-Ki Kim, Min-Soo Seo, Gun Woo Lee
Summary: Extracellular vesicles (EVs) are membrane-bound particles secreted by cells, and stem cell-derived EVs have been shown to have therapeutic effects similar to stem cells. This study isolated EVs from human epidural fat-derived mesenchymal stem cells and human fibroblasts, and found that EVs from the MSCs exhibited stronger anti-inflammatory effects compared to those from fibroblasts. The results suggest that EVs from human epidural fat MSCs may be valuable for treating inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
Soo-Eun Sung, Min-Soo Seo, Kyung-Ku Kang, Joo-Hee Choi, Si-Joon Lee, Ju-Hyeon Lim, Seung Yun Yang, Seul-Ki Kim, Gun Woo Lee
Summary: This study successfully isolated and characterized exosomes from epidural fat-derived mesenchymal stem cells, providing important insights for further research on the function and role of EF tissue.
ASIAN SPINE JOURNAL
(2022)
Article
Engineering, Biomedical
Min Jae Kim, Keum-Yong Seong, Da Som Kim, Jea Sic Jeong, So Young Kim, Seungsoo Lee, Seung Yun Yang, Beum-Soo An
Summary: Alopecia refers to hair loss in a specific part of the head, which can be caused by drugs, stress, and autoimmune disorders. This study investigates the use of hyaluronic acid (HA) in promoting hair dermal papilla (HDP) cell proliferation, migration, and aggregation to reduce hair loss in alopecia mice. The study also suggests the use of microneedles (MNs) as controlled drug delivery systems for better therapeutic effects and reduced side effects.
ACTA BIOMATERIALIA
(2022)
Article
Polymer Science
Sijoon Lee, Kyung-Ku Kang, Soo-Eun Sung, Joo-Hee Choi, Minkyoung Sung, Keum-Yong Seong, Sunjong Lee, Seung Yun Yang, Min-Soo Seo, KilSoo Kim
Summary: The production, use, and waste of plastics have led to environmental pollution and public health problems. This study investigated the toxicity of polyethylene microplastics in ICR mice and found that repeated oral administration can cause lung inflammation.
Article
Materials Science, Multidisciplinary
Jeong-Min Park, Haklae Lee, Hyun-Seok Choe, Suk-kyun Ahn, Keum-Yong Seong, Seung Yun Yang, Jae-Hyuk Kim
Summary: This study introduces a new generation of solid-state triplet-triplet annihilation upconversion (TTA-UC) host material - PCL, which is highly efficient, processable, and biocompatible. It can be used in various applications such as solar and biophotonic devices.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Chemistry, Multidisciplinary
Da Som Kim, Hyeseon Lee, Min Jae Kim, Keum-Yong Seong, Jea Sic Jeong, So Young Kim, Eui-Man Jung, Seung Yun Yang, Beum-Soo An
Summary: This study demonstrates that dissolvable and swellable microneedle patches made from hyaluronic acid (HA) or gelatin can improve skin elasticity. These patches increase dermal thickness by increasing elastin levels, preventing collagen degradation, and promoting fibroblast viability and proliferation.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Polymer Science
Hyeseon Lee, Keum-Yong Seong, Sodam Kim, Ajeesh Chandrasekharan, Dae Youn Hwang, Young Ki Hahn, Moon-Chang Baek, Jun Lee, Seung Yun Yang
Summary: In this study, a photocurable tissue adhesive was developed by introducing photocrosslinkable methacrylate groups into biodegradable hyaluronic acid, enabling strong tissue adhesion and wound sealing with short UV exposure. The mechanical properties and adhesion strength of the tissue adhesive could be easily manipulated by controlling the substitution rate of methacrylate and polymer concentration.
Article
Polymer Science
Sijoon Lee, Kyung-Ku Kang, Soo-Eun Sung, Joo-Hee Choi, Minkyoung Sung, Keum-Yong Seong, Jian Lee, Subin Kang, Seong Yun Yang, Sunjong Lee, Kyeong-Ryoon Lee, Min-Soo Seo, KilSoo Kim
Summary: The increased use of plastics has caused significant environmental pollution, especially in the form of microplastics. This study assessed the toxicity and pharmacokinetics of PTFE microplastics and found no observed toxic effects in mice administered doses of 2000 mg/kg or higher in both short-term and long-term exposures.
Article
Materials Science, Biomaterials
Hyeseon Lee, Tae Wook Lee, Ajeesh Chandrasekharan, Soo-Eun Sung, Sang-Gu Yim, Sodam Kim, Keum-Yong Seong, Min-Soo Seo, Seung Yun Yang
Summary: Stem cell therapies have great potential in regenerative medicine to restore normal tissue function. In this study, injectable hydrogels were developed to improve the efficacy of mesenchymal stem cells for treating inflammatory lesions. The hydrogels showed high cell viability and good biocompatibility, and increased expression of anti-inflammatory cytokines. In an animal model, the hydrogels reduced inflammation-related damage.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Multidisciplinary Sciences
So Yun Lee, Sangheon Jeon, Young Woo Kwon, Mina Kwon, Moon Sung Kang, Keum-Yong Seong, Tae-Eon Park, Seung Yun Yang, Dong-Wook Han, Suck Won Hong, Ki Su Kim
Summary: In this study, an adhesive hyaluronic acid-based gelatin nanofibrous membrane integrated with multiple light-emitting diode arrays was developed as a skin-attachable patch. Experimental results demonstrated that this medical device accelerated the wound healing process through the synergy of mimicking the extracellular matrix structure and LED irradiation.
Article
Immunology
Sang-Gu Yim, Yun-Ho Hwang, Seonyeong An, Keum-Yong Seong, Seo-Yeon Kim, Semin Kim, Hyeseon Lee, Kang-Oh Lee, Mi-Young Kim, Dokeun Kim, You-Jin Kim, Seung-Yun Yang
Summary: This study reports a transcutaneous smallpox vaccination method using a live vaccinia-coated microneedle (MN) patch prepared by a low-temperature multiple nanoliter-level dispensing system. The method enables accurate transdermal delivery of live vaccines and maintenance of bioactivity. The results show that the MN patch coated with the smallpox vaccine can enhance immune response and maintain viral activity at low and high temperatures.
Article
Biotechnology & Applied Microbiology
Hyeseon Lee, Ajeesh Chandrasekharan, Keum-Yong Seong, Yeon Ji Jo, Samdae Park, Seonyeong An, Seungsoo Lee, Hyeji Kim, Hyungju Ahn, Sungbaek Seo, Jong Soo Lee, Seung Yun Yang
Summary: This study reports a user-demand hydrogel-forming ocular glue based on multilength photo-crosslinkable hyaluronic acid, which achieves fast and effective wound closure under wet and dynamic conditions, while possessing cornea-like transparency and lubricating properties. In animal experiments, the glue showed improved wound healing efficacy.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Soo-Eun Sung, Min-Soo Seo, Young-In Kim, Kyung-Ku Kang, Joo-Hee Choi, Sijoon Lee, Minkyoung Sung, Sang-Gu Yim, Ju-Hyeon Lim, Hyun-Gyu Seok, Seung-Yun Yang, Gun-Woo Lee
Summary: This study demonstrated that exosomes isolated from human epidural adipose tissue-derived MSCs can help restore locomotor function in rats with SCI by reducing inflammatory response.
Article
Chemistry, Multidisciplinary
Moon Sung Kang, Mina Kwon, Seok Hyun Lee, Won-Hyeon Kim, Gyeong Won Lee, Hyo Jung Jo, Bongju Kim, Seung Yun Yang, Ki Su Kim, Dong-Wook Han
Summary: Recent advances in 3D bioprinting technologies have made it possible to fabricate complex live 3D tissue analogs. In this study, 3D printed skin equivalents with hair follicle structures and different layers were successfully fabricated using GelMA/HAMA bioink. The bioink accurately reproduced the composition of native skin and demonstrated excellent properties for skin tissue engineering and regeneration.
CHEMISTRY-AN ASIAN JOURNAL
(2022)