Splicing factor SRSF1 limits IFN-γ production via RhoH and ameliorates experimental nephritis

Splicing factor SRSF1 controls T cell homeostasis and its decreased levels are linked to lymphopenia in systemic lupus erythematosus

(2020) Takayuki Katsuyama et al.   RHEUMATOLOGY

Th1, Th2, and Th17 cytokines in systemic lupus erythematosus

(2019) Farhana Muhammad Yusoff et al.   AUTOIMMUNITY

Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity

(2019) Takayuki Katsuyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting interferons and their pathways in systemic lupus erythematosus

(2018) François Chasset et al.   AUTOIMMUNITY REVIEWS

Recent developments in systemic lupus erythematosus pathogenesis and applications for therapy

(2018) Mindy S. Lo et al.   CURRENT OPINION IN RHEUMATOLOGY

microRNA-mediated regulation of splicing factors SRSF1, SRSF2 and hnRNP A1 in context of their alternatively spliced 3′UTRs

(2018) Elżbieta Sokół et al.   EXPERIMENTAL CELL RESEARCH

SLE mortality remains disproportionately high, despite improvements over the last decade

(2018) R R Singh et al.   LUPUS

C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease

(2018) Antoine Dufour et al.   Nature Communications

Decreased expression of Serine/arginine-rich splicing factor 1 in T cells from patients with active systemic lupus erythematosus accounts for reduced expression of RasGRP1 and DNA methyltransferase 1

(2018) Michihiro Kono et al.   Arthritis & Rheumatology

Lupus-An Unrecognized Leading Cause of Death in Young Females: A Population-Based Study Using Nationwide Death Certificates, 2000-2015

(2018) Eric Y. Yen et al.   Arthritis & Rheumatology

Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus

(2018) Takayuki Katsuyama et al.   Frontiers in Immunology

Upregulated microRNA-485 suppresses apoptosis of renal tubular epithelial cells in mice with lupus nephritis via regulating the TGF-β-MAPK signaling pathway by inhibiting RhoA expression

(2018) Yu Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization

(2018) Norimasa Tamehiro et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Current prospects of type II interferon γ signaling and autoimmunity

(2017) Daniel S. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective

(2017) Vaishali R. Moulton et al.   TRENDS IN MOLECULAR MEDICINE

Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE

(2016) Cristina Rozo et al.   ANNALS OF THE RHEUMATIC DISEASES

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

(2016) Melissa E Munroe et al.   ANNALS OF THE RHEUMATIC DISEASES

Plasticity of Th17 Cells in Autoimmune Kidney Diseases

(2016) Christian F. Krebs et al.   JOURNAL OF IMMUNOLOGY

New insights into the immunopathogenesis of systemic lupus erythematosus

(2016) George C. Tsokos et al.   Nature Reviews Rheumatology

Evidence for genetic association of TBX21 and IFNG with systemic lupus erythematosus in a Chinese Han population

(2016) Rui-Xue Leng et al.   Scientific Reports

Pathogenesis of Renal Disease in Systemic Lupus Erythematosus—The Role of Autoantibodies and Lymphocytes Subset Abnormalities

(2015) Desmond Yap et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity

(2015) Vaishali R. Moulton et al.   JOURNAL OF CLINICAL INVESTIGATION

Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3ζ in Human T Cells

(2015) Vaishali R. Moulton et al.   PLoS One

RhoH Plays Critical Roles in Fc RI-Dependent Signal Transduction in Mast Cells

(2014) H. Oda et al.   JOURNAL OF IMMUNOLOGY

Emerging Functions of SRSF1, Splicing Factor and Oncoprotein, in RNA Metabolism and Cancer

(2014) S. Das et al.   MOLECULAR CANCER RESEARCH

Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders

(2013) Anja Troeger et al.   EXPERIMENTAL CELL RESEARCH

Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells

(2013) Hiroyo Oda et al.   IMMUNOLOGY LETTERS

Ubiquitination Regulates Expression of the Serine/Arginine-rich Splicing Factor 1 (SRSF1) in Normal and Systemic Lupus Erythematosus (SLE) T Cells

(2013) Vaishali R. Moulton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Splicing factor SF2/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription

(2013) V. R. Moulton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections

(2012) Amandine Crequer et al.   JOURNAL OF CLINICAL INVESTIGATION

Kidney-infiltrating CD4+ T-cell clones promote nephritis in lupus-prone mice

(2012) Akiko Okamoto et al.   KIDNEY INTERNATIONAL

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Tim3 Is Upregulated and Protective in Nephrotoxic Serum Nephritis

(2010) Andrea Schroll et al.   AMERICAN JOURNAL OF PATHOLOGY

RhoH modulates pre-TCR and TCR signalling by regulating LCK

(2010) Hong Wang et al.   CELLULAR SIGNALLING

Alternative Splicing Factor/Splicing Factor 2 Regulates the Expression of the ζ Subunit of the Human T Cell Receptor-associated CD3 Complex

(2010) Vaishali R. Moulton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling

(2010) Hee-Don Chae et al.   PLoS One

Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus

(2009) K. Kim et al.   ANNALS OF THE RHEUMATIC DISEASES

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

The RNA-stabilizing Protein HuR Regulates the Expression of ζ Chain of the Human T Cell Receptor-associated CD3 Complex

(2008) Vaishali R. Moulton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-bet Deficiency Attenuates Renal Injury in Experimental Crescentic Glomerulonephritis

(2008) R. K. S. Phoon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY