Article
Medicine, General & Internal
Wei-Jing Zhao, Xin-Yi Xia, Jun Yin
Summary: The study found that vitamin D deficiency is independently associated with a higher risk of DPN and DN in T2DM patients, but not DR. Additionally, vitamin D deficiency may serve as a potential predictor for both the occurrence and severity of DPN and DN.
CHINESE MEDICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Antonela Gverovic Antunica, Ljubo Znaor, Mira Ivankovic, Velibor Puzovic, Irena Markovic, Snjezana Kastelan
Summary: Diabetic retinopathy, the most common eye disease complication of diabetes, is associated with hypovitaminosis D. Vitamin D2 and D3 are the main forms of vitamin D, with sunlight being a major source. Vitamin D plays a crucial role not only in maintaining healthy bones and immune system but also in the development of various diseases, including diabetic retinopathy. Diagnosis of vitamin D deficiency, which is prevalent worldwide, is done through measuring serum concentration of 25-hydroxyvitamin D. Supplementation of vitamin D has been proven effective in treating diabetic retinopathy, but under the recommendation and supervision of a doctor to prevent potential negative side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Instruments & Instrumentation
Kopal Agarawal, Yogesh Anant Kulkarni, Sarika Wairkar
Summary: This review article focuses on the application of flavonoid nanoformulations in the treatment of diabetes, overcoming limitations by enhancing solubility, absorption, and therapeutic efficacy. These nanoformulations have the potential to be effective interventions for diabetes and its complications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Aleksi Tarkkonen, Tor-Bjorn Claesson, Marika I. Eriksson, Carol Forsblom, Lena M. Thorn, Paula Summanen, Per-Henrik Groop, Jukka Putaala, Daniel Gordin, Juha Martola
Summary: Using magnetic resonance imaging, we found that the optic tracts of individuals with type 1 diabetes were smaller than those of healthy controls, suggesting that chronic hyperglycemia also damages the optic tract. This damage was associated with various metabolic measures as well as diabetic complications such as eye disease, kidney disease, neuropathy, and cerebral microbleeds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Hui Huang, Yayong Luo, Qian Wang, Yihan Zhang, Zhongxia Li, Ruikun He, Xiangmei Chen, Zheyi Dong
Summary: Diabetes is a global health concern with increasing prevalence, and diabetic vascular complications pose a significant burden on individuals and medical resources. Vaccinium plants and their extracts, known for their bioactivity in reducing blood glucose, oxidative stress, and inflammation, show promise in managing diabetes and its complications. This review summarizes recent studies on the potential effects of Vaccinium on improving diabetes and specific complications such as kidney disease and retinopathy.
Article
Endocrinology & Metabolism
Yi Wu, Mingguang He, Wenyong Huang, Wei Wang
Summary: The association between retinal blood vessel flow and geometric parameters and the risk of diabetic retinopathy (DR) progression was investigated in a 2-year prospective cohort study. Swept-source optical coherence tomography angiography (OCTA) measurements of foveal avascular zone area, blood vessel density (VD), fractal dimension (FD), and blood vessel tortuosity (BVT) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were obtained. The study found that lower baseline VD, lower FD, and higher BVT in the DCP were significantly associated with DR progression. The addition of OCTA metrics improved the predictive ability of the original model for DR progression.
ACTA DIABETOLOGICA
(2023)
Review
Endocrinology & Metabolism
William B. Horton, Eugene J. Barrett
Summary: This review discusses the microvascular dysfunction in diabetes mellitus and cardiometabolic disease, suggesting that dysfunction can be an early marker of change. The study also found that familiar complications of diabetes can be late-stage manifestations of microvascular injury that begins years earlier. Advances in understanding normal microvascular function and early dysfunction are leading to novel preventative interventions at early stages of microvascular injury.
Review
Biochemistry & Molecular Biology
Ho-Yin Huang, Ting-Wei Lin, Zi-Xuan Hong, Lee-Moay Lim
Summary: Vitamin D is a hormone that participates in various physiological processes. It has been shown to have renoprotective effects by regulating endothelial function, preserving podocytes, modulating the renin-angiotensin-aldosterone system, and exerting anti-inflammatory effects. Current research suggests that vitamin D may delay the onset of diabetic kidney disease. This review summarizes the findings on the role of vitamin D in diabetic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xiaoyue Yang, Rui Hu, Yajun Zhu, Zhen Wang, Yilin Hou, Kangkang Su, Xiaoyu He, Guangyao Song
Summary: This article conducted a meta-analysis on the association between vitamin B12 levels and diabetic retinopathy in patients with type 2 diabetes. The study found a significant correlation between low serum vitamin B12 levels and the risk of diabetic retinopathy, especially in East Asian, South Asian, and mixed populations.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Melissa A. Elafros, Brian C. Callaghan, Lesli E. Skolarus, Loretta Vileikyte, John G. Lawrenson, Eva L. Feldman
Summary: Knowledge about microvascular complications of diabetes varies among patients and healthcare providers, with factors such as education level, disease duration, and socioeconomic status influencing patient knowledge. Misconceptions regarding appropriate screening practices for complications are common among healthcare providers. Further research is needed to identify interventions that can improve knowledge and outcomes for both patients and providers.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Review
Hematology
Shigeo Godo, Akira Suda, Jun Takahashi, Satoshi Yasuda, Hiroaki Shimokawa
Summary: Accumulating evidence over the past few decades has shown that structural and functional abnormalities of coronary microvasculature are highly prevalent and associated with adverse clinical outcomes in patients with various cardiovascular diseases. CMD has been recognized as an important clinical entity, with potential mechanisms including enhanced coronary vasoconstrictive reactivity at the microvascular level.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Cong Li, Honghua Yu, Zhuoting Zhu, Xianwen Shang, Yu Huang, Charumathi Sabanayagam, Xiaohong Yang, Lei Liu
Summary: This study aimed to explore the association between blood pressure and the risk of diabetic microvascular complications (DMCs). The results showed that participants with higher systolic blood pressure had a lower risk of DMCs, and hypertension defined by the 2017 ACC/AHA guidelines may not have a significant impact on the incidence of DMCs compared to the JNC 7 criteria.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Yeon-Ju Lee, Hye-Yoon Jeon, Ah-Jun Lee, Minsoo Kim, Kwon-Soo Ha
Summary: The role of dopamine in retinal vascular dysfunction in diabetic retinopathy (DR) remains unclear. This study found that dopamine can alleviate retinal microvascular leakage and abnormalities caused by hyperglycemic memory by inhibiting persistent oxidative stress and mitochondrial dysfunction.
Article
Medicine, General & Internal
Naba Al-Sari, Svetlana Kutuzova, Tommi Suvitaival, Peter Henriksen, Flemming Pociot, Peter Rossing, Douglas McCloskey, Cristina Legido-Quigley
Summary: Using blood small molecule profiling and machine learning, the risk of developing complications, such as kidney disease and retinopathy, in diabetes patients can be predicted. This precision diagnostic approach has the potential to be implemented in clinical settings to screen patients early and prevent complications.
Article
Endocrinology & Metabolism
Shan Gao, Hongliang Zhang, Chen Long, Zhenhua Xing
Summary: This study suggests that obesity may lead to a higher risk of chronic kidney disease progression and neuropathy in patients with type 2 diabetes. Fat mass index (FMI) and waist circumference (WC) are better indicators of obesity-related neuropathy risk than body mass index (BMI) in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
