Article
Medicine, General & Internal
Mesut Onal, Pervin Karli, Ayse Zehra Ozdemir, Adem Kocaman, Yunus Katirci, Gulnur Coban, Gulen Kubra Nakisli, Yesim Civil, Bahattin Avci
Summary: The diagnosis of endometriosis may be delayed due to non-deterministic symptoms and avoiding surgical interventions. This study found that serum kisspeptin levels were significantly different between endometriosis patients and healthy controls, but were unable to differentiate the severity of endometriosis. This suggests that kisspeptins may play a role in the pathogenesis of endometriosis and further research is needed.
Article
Obstetrics & Gynecology
Sara Alson, Ligita Jokubkiene, Emir Henic, Povilas Sladkevicius
Summary: The prevalence of endometrioma and deep infiltrating endometriosis (DIE) in women with subfertility undergoing their first assisted reproductive treatment, as assessed by systematic transvaginal ultrasound examination, was 21.8%. The majority of women with endometriosis were unaware of their condition.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Xi Yuan, Beverly W. X. Wong, Nau'shil Kaur Randhawa, Thu P. P. Win, Yiong Huak Chan, Li Ma, Eu-Leong Yong
Summary: This study compared the epidemiological features and clinical presentations of deep infiltrating endometriosis with endometrioma and adenomyosis, and identified risk factors for these conditions. The results showed that deep infiltrating endometriosis was associated with severe dysmenorrhoea and private surgical care, while adenomyosis was associated with higher fertility desire and lower body mass index. Therefore, patients with pain symptoms and subfertility should be referred early to a tertiary center for the diagnosis and management of deep infiltrating endometriosis.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2023)
Article
Medicine, General & Internal
Ming-Yao Qiu, Ya-Ping Wang, Ran Ren, Yan-Ru Sun, Shu-Qin Xiao, Lu Han
Summary: This study aims to investigate the clinical and histopathological features of peritoneal endometriosis (PEM) and deep infiltrating endometriosis (DIE). The main distribution of PEM and DIE was located in the posterior pelvic cavity, and different morphological lesions had different invasiveness rates and depths of invasion to the peritoneum. The Ki-67 expression of DIE in endometrioid glandular epithelium was significantly higher than that in other PEM lesions.
ANNALS OF MEDICINE
(2023)
Article
Obstetrics & Gynecology
Laura Buggio, Edgardo Somigliana, Greta Sergenti, Federica Ottolini, Dhouha Dridi, Paolo Vercellini
Summary: Our study failed to find an association between AGD and the presence of endometriosis. Therefore, AGD does not seem to be a reliable indicator of the presence of endometriosis in clinical practice.
REPRODUCTIVE SCIENCES
(2022)
Review
Medicine, General & Internal
Teresa Mira Gruber, Laura Ortlieb, Wolfgang Henrich, Sylvia Mechsner
Summary: Endometriosis and adenomyosis can cause pain, infertility, and obstetric complications in young women. Studies have shown associations between these conditions and preterm birth, cesarean section delivery, and placental abnormalities. However, more research is needed to understand the underlying mechanisms and establish causality, as many studies did not properly adjust for confounding factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sofie Orlov, Ligita Jokubkiene
Summary: In this study, the prevalence of ovarian endometrioma and/or deep endometriosis was found to be 25%, with adenomyosis at 12%. Deep endometriosis was present in about 9% of symptomatic women. Despite having symptoms, half of the women had no abnormal ultrasound findings.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Editorial Material
Obstetrics & Gynecology
Danielle Hardman, Robert Bennett, Emad Mikhail
Summary: The study demonstrates the use of laparoscopic ultrasound guidance for laparoscopic shaving of rectosigmoid endometriosis, which enhances complete excision and decreases recurrence.
FERTILITY AND STERILITY
(2023)
Review
Obstetrics & Gynecology
Jose Manuel Garcia Garcia, Valentina Vannuzzi, Chiara Donati, Caterina Bernacchioni, Paola Bruni, Felice Petraglia
Summary: Endometriosis, a chronic inflammation in women of reproductive age, is characterized by the presence of fibrotic tissue inside and around lesions. The development of fibrosis is influenced by various cell types and molecular mechanisms, such as platelets, myofibroblasts, macrophages, and sensory nerve fibers, as well as the involvement of transforming growth factor-beta, Notch receptor, and sphingosine 1-phosphate (S1P). Understanding these molecular mechanisms is important for identifying new drug targets and developing novel therapeutic approaches for endometriosis patients.
REPRODUCTIVE SCIENCES
(2023)
Article
Acoustics
Abdullah Nadeem, Alexander Habte, Areeba Ahsan, Rabeea Tariq, Areeba Aamir Ali Basaria
Summary: Deep infiltrating endometriosis (DIE) is a condition where endometrial tissue infiltrates the uterosacral ligament, urinary tract, rectovaginal, and retrocervical areas. It can also rarely occur in the urinary bladder, thoracic, and neural regions. Symptoms of DIE include dysmenorrhea, dyspareunia, urinary tract infections, and infertility, which overlap with other unrelated diseases. Various diagnostic modalities, such as transvaginal ultrasound and magnetic resonance imaging, can help detect and differentiate endometriosis lesions from other diseases. Clinical management typically involves laparoscopic surgery and hormonal therapy to improve quality of life and address reproductive goals.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Obstetrics & Gynecology
Audrey Pivano, Vanessa Pauly, Nicolas Pirro, Marine Alessandrini, Laurent Boyer, Pascal Auquier, Aubert Agostini
Summary: The implementation of an enhanced recovery after surgery program has a positive impact on patient outcomes after deep infiltrating endometriosis surgery, reducing hospital stay and abdominal or pelvic pain syndromes without increasing complications or readmissions within 30 days.
FERTILITY AND STERILITY
(2022)
Article
Multidisciplinary Sciences
Sweta Ravisankar, Kelsey E. Brooks, Melinda J. Murphy, Nash Redmayne, Junghyun Ryu, Jason M. Kinchen, Shawn L. Chavez, Jon D. Hennebold
Summary: The administration of gonadotropins during infertility treatment affects the development of ovarian follicles and the competency of oocytes. Metabolomics analysis identified unique metabolites in follicular fluid that were associated with different embryo classifications, with an increase in the cortisol to cortisone ratio observed in the blastocyst group. The glucocorticoid receptor NR3C1 plays a role in regulating follicular processes through paracrine signaling, but further studies are needed to understand its specific mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Monika Abramiuk, Karolina Frankowska, Krzysztof Kulak, Rafal Tarkowski, Paulina Mertowska, Sebastian Mertowski, Ewelina Grywalska
Summary: This study aimed to assess the levels of urocortin 1 (Ucn1) in the serum and peritoneal fluid of patients with endometriosis (EMS) and healthy women, as well as the association between Ucn1 and immune parameters. The findings showed that serum Ucn1 level was significantly higher in women with EMS compared to healthy patients. Moreover, higher serum Ucn1 levels were associated with advanced stages of the disease. Based on serum Ucn1 levels, it is possible to distinguish deep infiltrating endometriosis (DIE) from other types of EMS. These results suggest that Ucn1 could be a promising biomarker of EMS, but should be used in conjunction with other diagnostic methods to enhance effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Sebastian Harth, Hasan Emin Kaya, Felix Zeppernick, Ivo Meinhold-Heerlein, Joerg Keckstein, Selcuk Murat Yildiz, Emina Nurkan, Gabriele Anja Krombach, Fritz Christian Roller
Summary: The study evaluated the inter- and intraobserver variability of the updated #Enzian classification for endometriosis on MRI, as well as the influence of reader experience on interobserver concordance. The results showed that with sufficient experience, the #Enzian classification enables excellent inter- and intraobserver agreement in the MRI-based diagnosis of deep infiltrating endometriosis and endometriomas.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Raquel Silveira da Cunha Araujo, Sabina Bastos Maia, Juliane Dornelas Lucio, Moises Diogo de Lima, Helizabet Salomao Abdalla Ayroza Ribeiro, Paulo Augusto Ayroza Galvao Ribeiro
Summary: In patients with unilateral ovarian endometriomas, the lateral compartment was the most affected, with dense adhesions around the left ovarian fossa being common. Left-sided ovarian endometriomas were more prevalent, and the posterior and anterior compartments also showed frequent lesions.
Article
Pharmacology & Pharmacy
J. W. Chiao, Maxime Melikian, Liying Han, Chengsen Xue, Allen Tsao, Luxi Wang, Simon K. Mencher, John Fallon, Karim Solangi, Gildas Bertho, Long G. Wang
BIOCHEMICAL PHARMACOLOGY
(2016)
Article
Chemistry, Medicinal
Maxime Melikian, Baptiste Eluard, Gildas Bertho, Veronique Baud, Nathalie Evrard-Todeschi
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2017)
Article
Endocrinology & Metabolism
Margaux Luck, Caroline Schmitt, Neila Talbi, Laurent Gouya, Cedric Caradeuc, Herve Puy, Gildas Bertho, Nicolas Pallet
Article
Biochemistry & Molecular Biology
Manal Sarkis, Maria A. Miteva, Maria Chiara Dasso Lang, Maryse Jaouen, Marie-Agnes Sari, Marie-Odile Galcera, Melanie Etheve-Quelquejeu, Christiane Garbay, Gildas Bertho, Emmanuelle Braud
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2017)
Article
Neurosciences
Celine Desseille, Severine Deforges, Olivier Biondi, Leo Houdebine, Domenico D'amico, Antonin Lamaziere, Cedric Caradeuc, Gildas Bertho, Gaelle Bruneteau, Laure Weill, Jean Bastin, Fatima Djouadi, Francois Salachas, Philippe Lopes, Christophe Chanoine, Charbel Massaad, Frederic Charbonnier
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Correction
Endocrinology & Metabolism
Margaux Luck, Caroline Schmitt, Neila Talbi, Laurent Gouya, Cedric Caradeuc, Herve Puy, Gildas Bertho, Nicolas Pallet
Article
Medicine, General & Internal
Baptiste Fohlen, Quentin Tavernier, Thi-mum Huynh, Cedric Caradeuc, Delphine Le Corre, Gildas Bertho, Bernard Cholley, Nicolas Pallet
Article
Multidisciplinary Sciences
Margaux Luck, Gildas Bertho, Mathilde Bateson, Alexandre Karras, Anastasia Yartseva, Eric Thervet, Cecilia Damon, Nicolas Pallet
Article
Obstetrics & Gynecology
Chloe Maignien, Pietro Santulli, Fatiha Kateb, Cedric Caradeuc, Louis Marcellin, Khaled Pocate-Cheriet, Mathilde Bourdon, Sandrine Chouzenoux, Frederic Batteux, Gildas Bertho, Charles Chapron
REPRODUCTIVE BIOMEDICINE ONLINE
(2020)
Article
Biochemistry & Molecular Biology
Raoul Manuel, Michelle de Souza Lima, Sebastien Dilly, Sylvain Daunay, Patricia Abbe, Elodie Pramil, Stephanie Solier, Fabienne Guillaumond, Sarah-Simha Tubiana, Alexandre Escargueil, Joao Antonio Pegas Henriques, Nathalie Ferrand, Irene Erdelmeier, Jean-Luc Boucher, Gildas Bertho, Israel Agranat, Stephane Rocchi, Michele Sabbah, Anny Slama Schwok
Summary: Research on specific inhibition of NADPH oxidases (NOX) and NO-synthases (NOS) has attracted great pharmacological interest due to their association with redox stress in tumor cells. The study demonstrated that isolated 2'- and 3'-phosphate isomers of the NADPH analogue NS1 improved the specificity of inhibition by distinguishing between isomeric derivatives. The 2'-phosphate isomer of NS1 showed more pronounced effects on NOS and NOX-dependent physiological responses, with docking and molecular dynamics simulations explaining the specificity at the NADPH site of NOX and NOS.
Article
Chemistry, Multidisciplinary
Alexis Gosset, Stepanka Novakova Lachmanova, Sawsen Cherraben, Gildas Bertho, Jeremy Forte, Christian Perruchot, Henri-Pierre Jacquot de Rouville, Lubomir Pospisil, Magdalena Hromadova, Eric Bremond, Philippe P. Laine
Summary: The study of 2,2'-di(N-methylpyrid-4-ylium)-1,1'-biphenyl has revealed the emergence of a new SupLUMO electronic structure, as well as the superelectrophoric behavior of the cis isomer. These findings demonstrate the unique electronic properties of these molecules and their potential as tools for designing electroactive architectures.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Gildas Bertho, Imed Eddine Oumezziane, Cedric Caradeuc, Louis Guibout, Christine Balducci, Laurence Dinan, Pierre J. Dilda, Serge Camelo, Rene Lafont, Nicolas Giraud
Summary: This study reports the analysis of complex samples obtained from the microwave irradiation/heating of norbixin. Identifying the different isomers obtained during its degradation is of utmost importance. By utilizing 1D pure shift experiments and 2D NMR data analysis, the isomeric composition of norbixin samples was accurately described.
MAGNETIC RESONANCE IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Evrard Ablo, Souleymane Coulibaly, Siomenan Coulibali, Kouassi Signo, Patrick-Armand Achi, Nicolas Giraud, Gildas Bertho
Summary: Eighteen new N-acylhydrazones containing the imidazo[1,2-a]pyridine scaffold were synthesized through a seven-step reaction sequence. The synthesized compounds were characterized using NMR spectroscopy and mass spectrometry. It was found that the majority of the synthesized compounds exist in the syn-periplanar E conformer.
MAGNETIC RESONANCE IN CHEMISTRY
(2022)
Article
Chemistry, Physical
Karen Dos Santos, Gildas Bertho, Cedric Caradeuc, Veronique Baud, Aurelie Montagne, Daniel Abergel, Nicolas Giraud, Mathieu Baudin
Summary: Researchers used a new technique to study the metabolic changes of glutamine in cancer cells. They used [5-C-13] glutamine and [1,4-C-13] asparagine as molecular probes, studied the actions of several enzymes, and explored the use of hyperpolarized substrates to probe metabolic pathways. They also proposed a highly concentrated sample formulation for fast imaging applications.
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)