The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein

The assembly of succinate dehydrogenase: a key enzyme in bioenergetics

(2019) Behrooz Moosavi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Maturation of the respiratory complex II flavoprotein

(2019) Pankaj Sharma et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS

(2018) Elena Maklashina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An assembly factor promotes assembly of flavinated SDH1 into the succinate dehydrogenase complex

(2018) Katharina Belt et al.   PLANT PHYSIOLOGY

Crystal structure of bacterial succinate:quinone oxidoreductase flavoprotein SdhA in complex with its assembly factor SdhE

(2018) Megan J. Maher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of an assembly intermediate of respiratory Complex II

(2018) Pankaj Sharma et al.   Nature Communications

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

(2018) Ayenachew Bezawork-Geleta et al.   Nature Communications

Structural and biochemical analyses reveal insights into covalent flavinylation of theEscherichia coliComplex II homolog quinol:fumarate reductase

(2017) C. A. Starbird et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention

(2017) Birke Bausch et al.   JAMA Oncology

In-vitro, SDH5-dependent flavinylation of immobilized human respiratory complex II flavoprotein

(2016) Lala Zafreen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB

(2016) Nunziata Maio et al.   Cell Metabolism

Redox State of Flavin Adenine Dinucleotide Drives Substrate Binding and Product Release in Escherichia coli Succinate Dehydrogenase

(2015) Victor W. T. Cheng et al.   BIOCHEMISTRY

The LYR Factors SDHAF1 and SDHAF3 Mediate Maturation of the Iron-Sulfur Subunit of Succinate Dehydrogenase

(2014) Un Na et al.   Cell Metabolism

SDHAF4 Promotes Mitochondrial Succinate Dehydrogenase Activity and Prevents Neurodegeneration

(2014) Jonathan G. Van Vranken et al.   Cell Metabolism

Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA

(2014) Ayenachew Bezawork-Geleta et al.   FASEB JOURNAL

Analysis of covalent flavinylation using thermostable succinate dehydrogenase fromThermus thermophilusandSulfolobus tokodaiilacking SdhE homologs

(2014) Asako Kounosu   FEBS LETTERS

Solution NMR Structure of Yeast Succinate Dehydrogenase Flavinylation Factor Sdh5 Reveals a Putative Sdh1 Binding Site

(2012) Alexander Eletsky et al.   BIOCHEMISTRY

Catalytic mechanisms of complex II enzymes: A structural perspective

(2012) T.M. Iverson   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Structural Basis for Malfunction in Complex II

(2012) Tina M. Iverson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flavinylation and Assembly of Succinate Dehydrogenase Are Dependent on the C-terminal Tail of the Flavoprotein Subunit

(2012) Hyung J. Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SdhE Is a Conserved Protein Required for Flavinylation of Succinate Dehydrogenase in Bacteria

(2012) Matthew B. McNeil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate dehydrogenase assembly factor 2 is needed for assembly and activity of mitochondrial complex II and for normal root elongation in Arabidopsis

(2012) Shaobai Huang et al.   PLANT JOURNAL

Signal Transduction by Mitochondrial Oxidants

(2011) Toren Finkel   JOURNAL OF BIOLOGICAL CHEMISTRY

Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature

(2011) Qiangjun Zhou et al.   Protein & Cell

Familial neonatal isolated cardiomyopathy caused by a mutation in the flavoprotein subunit of succinate dehydrogenase

(2010) Aviva Levitas et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

SDHA is a tumor suppressor gene causing paraganglioma

(2010) Nelly Burnichon et al.   HUMAN MOLECULAR GENETICS

Geometric Restraint Drives On- and Off-pathway Catalysis by theEscherichia coliMenaquinol:Fumarate Reductase

(2010) Thomas M. Tomasiak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

What’s in a covalent bond?

(2009) Dominic P. H. M. Heuts et al.   FEBS Journal

Structure of Escherichia coli Succinate:Quinone Oxidoreductase with an Occupied and Empty Quinone-binding Site

(2009) Jonathan Ruprecht et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy

(2009) Daniele Ghezzi et al.   NATURE GENETICS

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Covalent flavinylation of vanillyl-alcohol oxidase is an autocatalytic process

(2008) Jianfeng Jin et al.   FEBS Journal

A Threonine on the Active Site Loop Controls Transition State Formation inEscherichia coliRespiratory Complex II

(2008) Thomas M. Tomasiak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY