Structure–function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay

High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM

(2019) Mark A. Herzik et al.   Nature Communications

A Quorum Sensing-Regulated Protein Binds Cell Wall Components and Enhances Lysozyme Resistance in Streptococcus pyogenes

(2018) Artemis Gogos et al.   JOURNAL OF BACTERIOLOGY

Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond

(2017) Reid V. Wilkening et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen

(2017) Hackwon Do et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of haemoglobin at 3.2 Å determined with the Volta phase plate

(2017) Maryam Khoshouei et al.   Nature Communications

PepO, a CovRS-controlled endopeptidase, disruptsStreptococcus pyogenesquorum sensing

(2015) Reid V. Wilkening et al.   MOLECULAR MICROBIOLOGY

Induction of a quorum sensing pathway by environmental signals enhances group A streptococcal resistance to lysozyme

(2015) Jennifer C. Chang et al.   MOLECULAR MICROBIOLOGY

Rgg protein structure–function and inhibition by cyclic peptide compounds

(2015) Vijay Parashar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci

(2015) Chaitanya Aggarwal et al.   mBio

Multiple Length Peptide-Pheromone Variants Produced byStreptococcus pyogenesDirectly Bind Rgg Proteins to Confer Transcriptional Regulation

(2014) Chaitanya Aggarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inactivation of the Rgg2 Transcriptional Regulator Ablates the Virulence of Streptococcus pyogenes

(2014) Anastasia A. Zutkis et al.   PLoS One

Quorum sensing in group A Streptococcus

(2014) Juan Cristobal Jimenez et al.   Frontiers in Cellular and Infection Microbiology

Rgg-Associated SHP Signaling Peptides Mediate Cross-Talk in Streptococci

(2013) Betty Fleuchot et al.   PLoS One

The Cryptic Competence Pathway in Streptococcus pyogenes Is Controlled by a Peptide Pheromone

(2012) L. Mashburn-Warren et al.   JOURNAL OF BACTERIOLOGY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Rgg proteins associated with internalized small hydrophobic peptides: a new quorum-sensing mechanism in streptococci

(2011) B. Fleuchot et al.   MOLECULAR MICROBIOLOGY

CURVES+ web server for analyzing and visualizing the helical, backbone and groove parameters of nucleic acid structures

(2011) C. Blanchet et al.   NUCLEIC ACIDS RESEARCH

Two Group A Streptococcal Peptide Pheromones Act through Opposing Rgg Regulators to Control Biofilm Development

(2011) Jennifer C. Chang et al.   PLoS Pathogens