COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment

Compounds with therapeutic potential against novel respiratory 2019 coronavirus

(2020) Miguel Angel Martinez   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure analysis of the receptor binding of 2019-nCoV

(2020) Yun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient

(2020) Sean Wei Xiang Ong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

(2020) Barnaby Edward Young et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

(2020) Calvin J Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Systematic Review of Lopinavir Therapy for SARS Coronavirus and MERS Coronavirus–A Possible Reference for Coronavirus Disease‐19 Treatment Option

(2020) Tian‐Tian Yao et al.   JOURNAL OF MEDICAL VIROLOGY

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Mechanisms of action of hydroxychloroquine and chloroquine: implications for rheumatology

(2020) Eva Schrezenmeier et al.   Nature Reviews Rheumatology

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of Chest CT in Combination with Negative RT-PCR Assay for the 2019 Novel Coronavirus but High Clinical Suspicion

(2020) Peikai Huang et al.   RADIOLOGY

Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR

(2020) Yicheng Fang et al.   RADIOLOGY

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

(2020) Wei Zhang et al.   Emerging Microbes & Infections

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

High-flow nasal-oxygenation-assisted fibreoptic tracheal intubation in critically ill patients with COVID-19 pneumonia: a prospective randomised controlled trial

(2020) Cai-Neng Wu et al.   BRITISH JOURNAL OF ANAESTHESIA

Thromboembolic risk and anticoagulant therapy in COVID‐19 patients: emerging evidence and call for action

(2020) Anastasios Kollias et al.   BRITISH JOURNAL OF HAEMATOLOGY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

(2020) Meijuan Zheng et al.   Cellular & Molecular Immunology

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Pathogenesis of COVID-19 from a cell biology perspective

(2020) Robert J. Mason   EUROPEAN RESPIRATORY JOURNAL

Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis

(2020) Ka Shing Cheung et al.   GASTROENTEROLOGY

The epidemiology, diagnosis and treatment of COVID-19

(2020) Pan Zhai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

(2020) Philippe Gautret et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Anti-IL6R role in treatment of COVID-19-related ARDS

(2020) Franco Maria Buonaguro et al.   Journal of Translational Medicine

Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study

(2020) Juanjuan Zhang et al.   LANCET INFECTIOUS DISEASES

Remdesivir for 5 or 10 Days in Patients with Severe Covid-19

(2020) Jason D. Goldman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Characteristics of Covid-19 in New York City

(2020) Parag Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

(2020) Jianjun Gao et al.   BioScience Trends

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)

(2020) Nicholas J. Mercuro et al.   JAMA Cardiology

COVID-19 pathophysiology: A review

(2020) Koichi Yuki et al.   CLINICAL IMMUNOLOGY

The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients

(2020) Ai-Ping Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Main Clinical Features of COVID-19 and Potential Prognostic and Therapeutic Value of the Microbiota in SARS-CoV-2 Infections

(2020) Yu He et al.   Frontiers in Microbiology

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

(2019) Egor Tchesnokov et al.   Viruses-Basel

Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome

(2018) Yaseen M. Arabi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses

(2015) Leonard B. Bacharier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Development and Evaluation of Novel Real-Time Reverse Transcription-PCR Assays with Locked Nucleic Acid Probes Targeting Leader Sequences of Human-Pathogenic Coronaviruses

(2015) Jasper Fuk-Woo Chan et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Real-Time Sequence-Validated Loop-Mediated Isothermal Amplification Assays for Detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

(2015) Sanchita Bhadra et al.   PLoS One

Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

(2012) Sandrine Belouzard et al.   Viruses-Basel

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA