Article
Pediatrics
Yang Lu, Zhe Lv, Jiner Cen, Jiwei Tao, Yun Zhang, Yifan Zhang, Jianbo Mao, Yiqi Chen, Mingyuan Wu, Shujun Chen, Lijun Shen
Summary: This study evaluated the sensitivity and specificity of four predictive algorithms (G-ROP, CO-ROP, Alex-ROP, and ROPscore) for retinopathy of prematurity and compared their performances in the Chinese population. The results showed that G-ROP, ROPscore, and CO-ROP had high sensitivity for severe ROP in the Chinese population, but both the sensitivity and specificity of Alex-ROP were low. CO-ROP provided the best performance for severe ROP in a fair comparison.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Ewa Strauss, Danuta Januszkiewicz-Lewandowska, Alicja Sobaniec, Anna Gotz-Wieckowska
Summary: This study evaluates the hypothesis that variation in the selenoprotein-encoding genes affects the risk of ROP and other comorbidities in premature newborns. The study found that the SELENOP rs3877899A allele is associated with the risk of ELGA and ROP requiring treatment. Additionally, factors such as the number of RBC transfusions, ELGA, surfactant treatment, and coexistence of the rs3877899A allele with ELGA were independent predictors of ROP onset and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Daniel Lemaitre, Amandine Barjol, Youssef Abdelmassih, Caroline Farnoux, Gilles C. Martin, Florence Metge, Thibaut Chapron, Georges Caputo
Summary: In this study, it was found that 28.1% of preterm infants received treatment for ROP less severe than pre-threshold type 1, mainly due to the persistent activity of the disease or the presence of pre-plus-stage disease. The data suggests the need to update ROP treatment criteria to align with real-life practices and further studies are required to evaluate the long-term benefits and side effects of treatments outside the recommended indications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Achim Fiess, Clara Hufschmidt-Merizian, Sandra Gissler, Ulrike Hampel, Eva Mildenberger, Michael S. Urschitz, Fred Zepp, Bernhard Stoffelns, Norbert Pfeiffer, Alexander K. Schuster
Summary: This study analyzed the effects of perinatal history on tear film properties and lid geometry in adults born preterm. The results indicate that perinatal history affects ocular surface properties, tear production and lid geometry in individuals born term and preterm.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Uday Tekchandani, Deeksha Katoch, Mangat R. Dogra
Summary: The study aimed to investigate the demographic profile and pattern of retinopathy of prematurity (ROP) at a tertiary care institute in India. Results showed that the overall incidence of any ROP was 32.3%, with severe ROP at 17.7%. Severe ROP was more common in outborns than inborns, and the proportion of infants with APROP increased over the years.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Sara Tawfik, Ahmed Mansour, Norhan Lotfy Selim, Ahmed M. Habib, Yousef A. Fouad, Mohamed A. Tawfik, Mariam Al-Feky
Summary: The incidence of both ROP and AP-ROP in the Egyptian rural setting appears to be in the high end of global reported rates. Prevention measures should urgently be planned and implemented.
Article
Pediatrics
Rama Krushna Gudu, Manmath Kumar Das, Pravati Jena, Santosh Kumar Panda
Summary: This retrospective study evaluated the trends in the use of anti-vascular endothelial growth factor (anti-VEGF) for the treatment of type-1 retinopathy of prematurity (ROP) in a neonatal unit of India. The study found an increasing trend in the use of anti-VEGF for ROP management over time. Anti-VEGF showed equal efficacy as laser therapy for zone 1 ROP and aggressive-posterior ROP, but laser therapy was more effective for zone 2 ROP.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Huiqing Sun, Yubin Dong, Yanxia Liu, Qingqin Chen, Yanxi Wang, Bin Cheng, Shaobo Qin, Liping Meng, Shanxiu Li, Yanlun Zhang, Aiguo Zhang, Weiling Yan, Yuhong Dong, Shuyi Cheng, Mingchao Li, Zengyuan Yu
Summary: Retinopathy of prematurity (ROP) is a disease that affects vision in premature infants. ROPScore and CHOP ROP are similar scoring models used to predict ROP. A study in China found that CHOP ROP had higher sensitivity (100%) for predicting type 1 ROP compared to ROPScore.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Tamara Lee Lenis, Nahomy Ledesma Vicioso, Varun Reddy, Kyle D. Kovacs, Sarah H. Van Tassel, Anton Orlin
Summary: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness due to incomplete development of retinal blood vessels in preterm infants. Some ROP patients may develop glaucoma as a ocular comorbidity, with multifactorial etiology including incomplete angle development, ischemia, and laser treatment, emphasizing the need for glaucoma screening in the short and long term.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Sarah Sonny, Huijun Yuan, Shaoyi Chen, Matthew R. Duncan, Pingping Chen, Merline Benny, Karen Young, Kevin K. Park, Augusto F. Schmidt, Shu Wu
Summary: The inhibition of gasdermin D (GSDMD) can alleviate hyperoxia-induced bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) in premature infants by reducing macrophage infiltration, improving alveolarization and vascular development, decreasing cell death, and preventing vasoobliteration, neovascularization, thinning of retinal tissue layers, and microglial activation.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Alex T. Legocki, Aaron Y. Lee, Leona Ding, Yasman Moshiri, Emily M. Zepeda, Thomas B. Gillette, Laura E. Grant, Ayesha Shariff, Phanith Touch, Cecilia S. Lee, Kristina Tarczy-Hornoch, Michelle T. Cabrera
Summary: The purpose of this study was to develop models predicting early referral-warranted retinopathy of prematurity (ROP) using non-contact handheld spectral-domain optical coherence tomography (OCT) and demographic data. The study found that the models using handheld OCT biomarkers can identify early referral-warranted ROP with high accuracy, while machine learning models were less optimal.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Pediatrics
Yaoyao Sun, Kaixin Deng, Xiaoxin Li, Min Zhao, Yanrong Jiang, Hong Yin, Huijun Qi, Tong Qian, Dandan Linghu, Wenzhen Yu, Mingwei Zhao, Jianhong Liang
Summary: The study aimed to determine the incidence of fundus hemorrhage (FH) not associated with retinopathy of prematurity (ROP) during ocular screening and report their clinical features, risk factors, therapies, and prognosis. The study found that FH not caused by ROP is more likely to present as superficial, peripheral hemorrhages, and vaginal delivery compression and forceps may be associated with hemorrhage.
FRONTIERS IN PEDIATRICS
(2022)
Review
Ophthalmology
M. Elizabeth Hartnett, Andreas Stahl
Summary: Retinopathy of prematurity (ROP) is a major cause of childhood blindness, characterized by overgrowth of blood vessels into the vitreous and complex retinal detachments. Our understanding of ROP has expanded to include insufficient developmental retinal vascular growth in early stages. Current treatments focus on improving perinatal care, reducing premature birth, and addressing vasoproliferation in affected eyes.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Omar A. Bokhary, Abdulelah G. Abumohssin, Maha K. Alghamdi, Suhail K. Abualnaja, Hamza L. Fida, Nizar M. Alhibshi
Summary: Prematurity is a leading cause of neonatal morbidity and mortality and is associated with insufficient development of multiple body structures, including neurovascular and retinal tissues. Retinopathy of prematurity (ROP) is an abnormal vaso proliferation of the neonatal retina that results from an arrest in the normal development of the retinal nerve and blood supply. This study aimed to assess the initial clinical and laboratory characteristics of preterm infants at the time of birth and identify population-specific risk factors for the development of ROP. The results showed a significant association between low birth weight and gestational age with the development of ROP.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Engineering, Biomedical
Ning Hou, Jianhua Shi, Xiaoxuan Ding, Chuan Nie, Cuicui Wang, Jiafu Wan
Summary: In this study, we propose an image synthesis method for retinopathy of prematurity (ROP) based on generative adversarial networks. The method utilizes image segmentation and adversarial autoencoder techniques to generate diverse ROP images. Experimental results demonstrate that the proposed method can generate realistic ROP fundus images.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Letter
Ophthalmology
Bhupesh Bagga, Savitri Sharma, Ruchi Pratap Singh Gour, Joveeta Joseph, Ashik Mohamed, Varsha Rathi, Prashant Garg
Article
Ophthalmology
Swathi Kaliki, Richa Dharap Wagh, Vijitha S. Vempuluru, Anasua Ganguly Kapoor, Saumya Jakati, Dilip K. Mishra, Ashik Mohamed
Summary: Orbital tumour extension of ocular surface squamous neoplasia (OSSN) is rare and is associated with risk factors such as outdoor occupation, HIV infection, prolonged duration of symptoms, and tumour bilaterality.
Article
Ophthalmology
Philippa Lloyd, Mark Westcott, Swathi Kaliki, Xunda Ji, Yihua Zou, Riffat Rashid, Sadia Sultana, Sadik Taju Sherief, Nathalie Cassoux, Rosdali Yesenia Diaz Coronado, Juan Luis Garcia Leon, Arturo Manuel Zapata Lopez, Vladimir G. Polyakov, Tatiana L. Ushakova, Soma Rani Roy, Alia Ahmad, Lamis Al Harby, Jesse L. Berry, Jonathan Kim, Ashley Polski, Nicholas J. Astbury, Covadonga Bascaran, Sharon Blum, Richard Bowman, Matthew J. Burton, Allen Foster, Nir Gomel, Naama Keren-Froim, Shiran Madgar, Andrew W. Stacey, Ashik Mohamed, Marcia Zondervan, Mandeep S. Sagoo, Ido Didi Fabian, M. Ashwin Reddy
Summary: This cohort study found no association between advanced maternal age, birth order, or GDP per capita and the development of a de novo pathogenic variant in RB1.
Article
Ophthalmology
Ashi Morawala, Ashik Mohamed, Ajay Krishnamurthy, Sai Divya Jajapuram, Swathi Kaliki
Summary: This study assessed the prognostic value of the T category of the 8th edition AJCC classification in periocular sebaceous gland carcinoma (SGC). The results showed that T4 tumors had higher rates of lymph node metastasis, systemic metastasis, and death compared to T1, T2, and T3 tumors. However, there was no significant association between T category and tumor recurrence.
Article
Ophthalmology
Jaishree Gandhi, Satyashree Gagan, Ashik Mohamed, Taraprasad Das, Vivek Pravin Dave, Joveeta Joseph
Summary: The study suggests that vitreous Galactomannan (GM) and 1,3 beta-D-Glucan (BDG) levels can be used for the diagnosis of fungal endophthalmitis, including culture-negative cases.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Anahita Kate, Bhupesh Bagga, Lakshmi Prasanna Ponnapati, Shalini Singh, Sahil Shah, Ashik Mohamed, Joveeta Joseph
Summary: The purpose of this study was to compare the clinico-microbiological features and outcomes of Serratia keratitis and Pseudomonas aeruginosa keratitis. The results showed that Serratia keratitis usually occurs in eyes with a compromised surface and has good resolution with medical therapy. There were no significant differences in outcomes between Serratia and Pseudomonas aeruginosa keratitis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Vivek Pravin Dave, Akash Belenje, Avantika Dogra, Taraprasad Das
Summary: This study aimed to describe and validate a novel inflammatory score (IS) system for managing infectious endophthalmitis. The study included patients with acute post-cataract surgery endophthalmitis and scored the severity of inflammation in four ocular tissues. The results demonstrated that the IS scoring system had good consistency and accuracy, and can be used for decision-making in the treatment and monitoring of infectious endophthalmitis.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemical Research Methods
Duardo Martinez-Enriquez, Andrea Curatolo, Alberto de Castro, Judith S. Birkenfeld, Ana M. Gonzalez, Ashik Mohamed, Marco Ruggeri, Fabrice Manns, Zvietcovich Fernando, Susana Marcos
Summary: In this study, we successfully estimated the full shape of the in vivo crystalline lens using the eigenlenses method, which only utilizes information visible through the pupil. Compared to previous methods, eigenlenses showed improved repeatability, robustness, and computational resource utilization in estimating crystalline lens shape. Eigenlenses can efficiently describe the full shape changes of the crystalline lens with accommodation and refractive error.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Goura Chattannavar, Ashik Mohamed, Vishwesh Malgi, Ramesh Kekunnaya
Summary: This study compared the visual, refractive, and surgical outcomes of intraocular lens (IOL) implantation and aphakia in children with microspherophakia. The results showed that in-the-bag IOL implantation can be considered as a treatment option, especially in developing nations with limited resources for regular follow-up.
BMJ OPEN OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Niroj Kumar Sahoo, Anjali Suresh, Ashika Patil, Joshua Ong, Eman Kazi, Mudit Tyagi, Raja Narayanan, Sameera Nayak, Ninan Jacob, Ramesh Venkatesh, Jay Chhablani
Summary: This study aimed to determine the postoperative en face OCT pattern of closure in idiopathic macular holes (MHs). Two different closure patterns, linear and round, were observed on en face OCT. Patients with linear closure had better visual acuity. Further research is needed to determine the functional significance of these closure patterns.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Tapas R. Padhi, Miloni Shah, Suman Sahoo, Taraprasad Das, Utpal Bhusal, Abinash Singh, Souvik Bhunia, Sameer Nayak, Sameera Nayak, Bhavik Panchal, Komal Agrawal, Balakrushna Samantaray, Sabita Devi, Krishna Rao, Lingaraj Pradhan, Ashik Mohamed, Subhadra Jalali
Summary: This study reported the demographic profile and clinical characteristics of retinopathy of prematurity (ROP) in posterior Zone I. The study included 130 eyes of 67 infants with a mean gestational age and birth weight of 29.3 (+/- 2.2) weeks and 1217.3 (+/- 381.9) grams, respectively. ROP in posterior Zone I has distinct features and subtypes different from ROP in other zones.
Article
Ophthalmology
Vivek Pravin Dave, Anthony Vipin Das, Sameera Nayak, Bhavik Panchal, Ferenc Kuhn
Summary: This study retrospectively analyzed the clinical presentations, management, and factors affecting outcomes in 2,360 cases of posterior segment open globe injuries. The results showed that posterior open globe injuries generally have a favorable functional outcome in the absence of retinal detachment and orbital fracture. Several factors associated with a favorable functional outcome were identified.
Article
Biochemical Research Methods
Eduardo Martinez-Enriquez, Bianca Maceo Heilman, Alberto de Castro, Ashik Mohamed, Marco Ruggeri, Fermamdp Zvietcovich, Fabrice Manns, Susana Marcos
Summary: Quantifying the geometry of human crystalline lens as a function of age and accommodation is crucial for better treatments of cataract and presbyopia. This study validates the use of eigenlenses to estimate the full shape of dis-accommodated lenses in vivo. The results demonstrate that eigenlenses can accurately estimate the shape of dis-accommodated lenses.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Ophthalmology
Komal Agarwal, Anthony Vipin Das, Tapas Ranjan Padhi, Sushma Jayanna, Bhavik Panchal, Sameera Nayak, Taraprasad Das, Subhadra Jalali
Summary: This study aims to describe the spectrum and demographic distribution of non-oncological retinal diseases in children and adolescents in an ophthalmic hospital network in India. It found that 8.44% of new patients aged 0-21 years were diagnosed with non-oncological retinal pathology in at least one eye. The major retinal diseases included retinopathy of prematurity, retinal dystrophy, and retinal detachment.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Vijitha S. Vempuluru, Neha Ghose, Monalisha Pattnaik, Ashik Mohamed, Swathi Kaliki
Summary: This study compared the risk factors, clinical features, and management outcomes of ocular surface squamous neoplasia (OSSN) with 360 degrees of limbal involvement (360-OSSN) and segmental limbal involvement (SL-OSSN). The results showed that 360-OSSN patients more often had longer duration of symptoms, prior misdiagnosis, and prior intervention. They also had a higher incidence of scleral fixity, corneal/scleral melt, intraocular and orbital tumor extension, and advanced T stage at presentation compared to SL-OSSN patients. Furthermore, lymph node and distant metastasis were more common in the 360-OSSN group during the follow-up period. Aggressive management is required for this advanced form of the disease.
INTERNATIONAL OPHTHALMOLOGY
(2023)
