Review
Polymer Science
Dong-Jin Lim
Summary: Methylene blue (MB) has been utilized in the textile industry and for pharmacological purposes. It has gained attention for its potential as a safe photosensitizer in photodynamic therapy (PDT), showing both anticancer and antibacterial activity. Challenges in creating MB-embedded nanoparticles or microparticles may affect the clinical efficacy of PDT.
Article
Nanoscience & Nanotechnology
Sanghee Lee, Ji Won Kim, Jinhwan Park, Hee Kyong Na, Do Hoon Kim, Jin Hee Noh, Dae Sung Ryu, Jae Myung Park, Jung-Hoon Park, Hwoon-Yong Jung, Kun Na
Summary: Bariatric surgery is the most effective treatment for weight recidivism, and endoscopic bariatric treatment has been developed to achieve similar effects without anatomical modification. This study explores the use of an intragastric satiety-inducing device (ISD) coated with a photosensitizer (MB) for photodynamic therapy (PDT) in inhibiting ghrelin secretion and inducing satiety signals. The results show the potential of this novel endoscopic bariatric therapy in reducing body weight gain and ghrelin levels.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Oncology
Karen Muller Ramalho, Sandra Ribeiro Cunha, Flavia Goncalves, Gustavo Silva Escudeiro, Carolina Steiner-Oliveira, Anna Carolina Rato Tempestini Horliana, Carlos de Paula Eduardo
Summary: The study compared photodynamic therapy, topical acyclovir, and the combination of both in the treatment of herpes simplex virus type 1 recurrences. It was found that on day 1, photodynamic therapy showed better results in treating herpes lesions compared to acyclovir.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Engineering, Biomedical
Ana Waleska Pessoa Barros, Pedro Henrique da Hora Sales, Paulo Goberlanio de Barros Silva, Ana Claudia Amorim Gomes, Alessandra Albuquerque Tavares Carvalho, Jair Carneiro Leao
Summary: This systematic review aimed to evaluate the effectiveness of low-level laser therapy in treating herpes labialis. The findings showed that low-level laser therapy significantly reduced tissue healing time, but had no significant effect on crust formation time. However, due to the high risk of bias in the included studies, more standardized research is needed to prove the effectiveness of this therapy.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biophysics
Thais P. Pivetta, Quirina Ferreira, Tania Vieira, Jorge C. Silva, Sandra Simo, Paulo A. Ribeiro, Maria Raposo
Summary: Photodynamic therapy utilizes photosensitizer molecules for the treatment of diseases, but stability and encapsulation efficiency are influenced by lipid composition. Some lipid compositions can enhance stability of liposomes, while Acridine Orange has greater affinity for vesicles. Different liposomes have varied effects on cytotoxicity and phototoxicity in tumor cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
Juan Zhao, Lixian Xu, Hao Zhang, Yuhong Zhuo, Yanan Weng, Shuang Li, Dinghua Yu
Summary: The study demonstrated that the lipopeptide surfactin-methylene blue complex can effectively enhance the accumulation of methylene blue inside cells, thereby improving the efficacy of antibacterial photodynamic therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Amir Taldaev, Roman Terekhov, Ilya Nikitin, Elizaveta Melnik, Vera Kuzina, Mikhail Klochko, Igor Reshetov, Artem Shiryaev, Victor Loschenov, Galina Ramenskaya
Summary: This systematic review examines the efficacy of methylene blue in photodynamic anticancer therapy. The analysis of relevant articles reveals that methylene blue can effectively inhibit the progression of different types of cancer, with enhanced effectiveness observed when used with nanopharmaceutics.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Thais Lazzarotto Braga, Pollyanna Cristina Vincenzi Conrado, Leticia Graziela Zavadzki Silva, Eduardo Victor Bergmann, Ana Claudia Pedrozo da Silva, Patricia de Souza Bonfim de Mendonca, Jane Martha Graton Mikcha, Leandro S. Herculano, Luis Carlos Malacarne, Edvani Curt i Muniz, Camila Fabiano de Freitas, Wilker Caetano
Summary: The combination of photodynamic therapy (PDT) and photothermal therapy (PTT) using methylene blue (MB) and gold nanoparticles (AuNPs) has shown promise as an effective treatment for microbial diseases. The use of ABA triblock Pluronic (R) P-123 copolymer as a carrier and stabilizing agent for AuNPs has proven to be efficient in obtaining reproducible samples. The synthesis of AuNPs presented plasmonic resonance peaks ranging from 535 to 554 nm, indicating spherical AuNPs. The combination therapy demonstrated both photodynamic and photothermal effects, with synergy observed in the generation of singlet oxygen and heat. The samples showed significant antifungal and antibacterial activity, making this approach a potential method for treating microbial infections.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Dermatology
Mona Soliman, Manal Salah, Maha Fadel, Maha Nasr, Heba El-Azab
Summary: This study compared the safety and efficacy of PDL and MB-PDT in treating acne, with MB-PDT showing more effectiveness in reducing acne severity and better patient tolerance.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Edris Pordel, Trife Ghasemi, Shima Afrasiabi, Stefano Benedicenti, Antonio Signore, Nasim Chiniforush
Summary: The aim of this study was to investigate the effects of antimicrobial photodynamic therapy (aPDT) using the blue diode laser (BDL) with different output powers and the photosensitizers riboflavin and curcumin on reducing the number of Streptococcus mutans around orthodontic brackets. The results showed that curcumin plus BDL with an output power of 500 mW and chlorhexidine had the highest reduction in S. mutans colony numbers. Curcumin was found to be more effective than riboflavin, and riboflavin with 200 mW output power showed no significant difference from the control group.
Article
Biochemical Research Methods
Sebastian Gnat, Dominik Lagowski, Mariusz Dylag, Jessica Zielinski, Aneta Nowakiewicz
Summary: The intense search for the Holy Grail of antifungal therapy is not limited to discovering potential antifungal drugs, but also includes new therapeutic strategies involving chemosensitizers or inducing stress conditions in fungal cells. This study confirms that methylene blue induced by red light has a definite inhibitory effect on zoophilic dermatophytes.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Engineering, Biomedical
In-Kyu Park, Do-Bin Ju, Amal Babu, Jeong-Cheol Lee, Young Jin Pyung, Chong-Su Cho, Hyun-Joong Kim
Summary: This study evaluated the in vitro photodynamic therapy of methylene blue-loaded acetyl resistant starch nanoparticles. The results showed that the nanoparticles had ordered nanosized structures and could generate more reactive oxygen species under near-infrared laser irradiation, leading to increased phototoxicity.
BIOMATERIALS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Vitor Luca Moura Marmo, Jessica A. R. Ambrosio, Erika Peterson Goncalves, Leandro Jose Raniero, Milton Beltrame Junior, Juliana G. Pinto, Juliana Ferreira-Strixino, Andreza R. Simioni
Summary: The aim of this study was to develop porous calcium carbonate microparticles in the vaterite phase for the encapsulation of methylene blue (MB) as a photosensitizer for use in photodynamic therapy. The MB-loaded microparticles exhibited promising photodynamic activity in macrophages infected with Leishmania braziliensis.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2023)
Article
Oncology
Alejandra Brenes-Alvarado, Jorge Soto-Montero, Felipe Fabricio Farias-da-Silva, Juliana Benine-Warlet, Andreza Ferraz Ribeiro, Francisco Carlos Groppo, Carolina Steiner-Oliveira
Summary: The study evaluated the efficacy of methylene blue (MB)-mediated antimicrobial photodynamic therapy doped with potassium iodide (KI) against oral microcosms biofilms cultured in dentin. Results showed that the addition of KI was effective in reducing oral microorganisms in the biofilms, but the effect varied among different treatment groups.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
R. F. Turchiello, C. S. Oliveira, A. U. Fernandes, S. L. Gomez, M. S. Baptista
Summary: Retinoblastoma is a rare pediatric tumor that typically occurs in early life, with symptoms including leukocoria or cat's eye reflex. In this study, Photodynamic treatment (Pdt) was found to have varying effects on two human retinoblastoma cell lines, with Y79 cells showing a higher sensitivity. Results from MTT assay and singlet oxygen emission measurements further confirmed this observation.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rafael Soares Diniz, Leticia Fecury Bogea de Albuquerque, Rudys de Jesus Rodolfo Tavarez, Eduardo Buozzi Moffa, Andrea Dias Neves Lago, Leticia Machado Goncalves
BRAZILIAN ORAL RESEARCH
(2019)
Article
Integrative & Complementary Medicine
Leticia Machado Goncalves, Petrus Levid Barros Madeira, Rafael Soares Diniz, Rammon Farias Nonato, Fabiana Suelen Figueredo de Siqueira, Eduardo Martins de Sousa, David Cardoso Sandes Farias, Flaviane Maria Galvao Rocha, Carlos Henrique Lopes Rocha, Andrea Dias Neves Lago, Cristina de Andrade Monteiro
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Engineering, Biomedical
Fernanda Cristina Nogueira Rodrigues, Julia Gomes Lucio de Araujo, Erika Michele dos Santos Araujo, Andrea Dias Neves Lago, Tais Fonseca Mantilla, Patricia Moreira de Freitas
Summary: The study found that all groups had a decrease in output power after placing protective material, with PEAD showing a greater reduction in power than PVC for both red and infrared wavelengths. PVC was concluded to be the most suitable biosafety material for protecting the tip of low power lasers among those tested.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Oncology
Guilherme Silva Furtado, Marco Aurelio Benini Paschoal, Liliana do Carmo Santos Grenho, Andrea Dias Neves Lago
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2020)
Article
Oncology
Bianca Rossi de Souza, Andrea Dias Neves Lago, Leila Soares Ferreira, Eric Mayer-Santos, Patricia Moreira de Freitas, Susana Morimoto, Karen Muller Ramalho
Summary: This study reported the development of two different dental bleaching protocols using a new technology, violet LED, and found that different treatment methods did not lead to significant differences in the final color outcome and sensitivity when using the violet LED for teeth whitening.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Carlos Felipe Sousa Menezes, Guilherme Silva Furtado, Giovanna Sarra, Marcia Martins Marques, Vandilson Pinheiro Rodrigues, Andrea Dias Neves Lago
Summary: The effectiveness, enamel surface microhardness, and biological safety of the violet led dental bleaching technique were investigated. The results showed that the violet led irradiation produced significant color changes while preserving tooth enamel integrity and causing no genotoxic effects on vital cells.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Medicine, General & Internal
Ricardo Roberto de Souza Fonseca, Camila Pantoja Silva, Beatriz Leal de Senna Sastre, Erich Brito Tanaka, Tabata Resque Beckmann Carvalho, Paula Gabriela Faciola Pessoa de Oliveira, Silvio Augusto Fernandes de Menezes, Rogerio Valois Laurentino, Renata Pimentel de Oliveira, Roberta Pimentel de Oliveira, Andrea Dias Neves Lago, Luiz Fernando Almeida Machado
Summary: This study aimed to evaluate the clinical results of a bilateral root coverage (RC) of gingival recession (GR) associated with an autogenous connective tissue graft (aCTG) alone or combined with low-level laser therapy (aCTG + LLLT). The results indicated that aCTG + LLLT might have an additional benefit to GR root coverage within the evaluated time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Rosely Cordon, Andrea Dias Neves Lago, Marcia Cristina Dias de Moraes, Luciane Franco Kraul, Rosane de Fatima Zanirato Lizarelli, Paulo Ney Lyra de Moraes, Gelza Matos Nunes, Yose Marie Elizabeth Silva, Rayssa Ferreira Cavaleiro de Macedo, Rodrigo Marcos Labat
Summary: This study aims to assess the evidence and knowledge gaps in photobiomodulation (PBM) for oral facial pain, with the goal of identifying a noninvasive treatment resource.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Andrea Dias Neves Lago, Rosely Cordon, Leticia Machado Goncalves, Carlos Felipe Sousa Menezes, Guilherme Silva Furtado, Fernanda Cristina Nogueira Rodrigues, Daniele Meire Conde Marques
Summary: This systematic review of literature on biosafety with the use of lasers highlights the high risk of contamination for dental surgeons. High-power lasers produce aerosols that need to be controlled, while low-power lasers must be protected to minimize the risks of cross-infection. This study emphasizes the importance of biosafety measures for professionals, staff, and patients, and suggests the need for more clinical studies in this area.
SPECIAL CARE IN DENTISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Erika Michele dos Santos Araujo, Beatriz Togoro Ferreira da Silva, Luciana Icfouri Siriani, Andrea Dias Neves Lago, Maria Regina Lorenzetti Simionato, Adriana Bona Matos
AMERICAN JOURNAL OF DENTISTRY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Gomes Lucio de Araujol, Erika Michele dos Santos Araujo, Fernanda Cristina Nogueira Rodrigues, Marco Aurelio Benini Paschoal, Andrea Dias Neves Lago
JOURNAL OF LASERS IN MEDICAL SCIENCES
(2019)
