Journal
PEDIATRICS
Volume 146, Issue 4, Pages -Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2020-0709
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Funding
- National Institute of Food and Agriculture, US Department of Agriculture [2011-68001-30207]
- National Institutes of Health/National Institute of Child Health and Human Development through a K23 Mentored Patient-Oriented Research Career Development Award [K23HD081077]
- National Institutes of Health (NIH)
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Primary care-based child obesity prevention from pregnancy through early childhood may reduce child weight trajectories among socioeconomic and ethnic groups with known disparities. OBJECTIVES: To determine impact of a primary care-based child obesity prevention intervention beginning during pregnancy on early childhood weight outcomes in low-income Hispanic families. METHODS: A randomized controlled trial comparing mother-infant pairs receiving either standard care or the Starting Early Program providing prenatal and postpartum nutrition counseling and nutrition parenting support groups targeting key obesity-related feeding practices in low-income groups. Primary outcomes were reduction in weight-for-agez-scores (WFAzs) from clinical anthropometric measures, obesity prevalence (weight for age >= 95th percentile), and excess weight gain (WFAz trajectory) from birth to age 3 years. Secondary outcomes included dose effects. RESULTS: Pregnant women (n= 566) were enrolled in the third trimester; 533 randomized to intervention (n= 266) or control (n= 267). Also, 358 children had their weight measured at age 2 years; 285 children had weight measured at age 3 years. Intervention infants had lower mean WFAz at 18 months (0.49 vs 0.73,P= .04) and 2 years (0.56 vs 0.81,P= .03) but not at 3 years (0.63 vs 0.59,P= .76). No group differences in obesity prevalence were found. When generalized estimating equations were used, significant average treatment effects were detected between 10-26 months (B = -0.19,P= .047), although not through age 3 years. In within group dose analyses at 3 years, obesity rates (26.4%, 22.5%, 8.0%,P= .02) decreased as attendance increased with low, medium, and high attendance. CONCLUSIONS: Mean WFAz and growth trajectories were lower for the intervention group through age 2 years, but there were no group differences at age 3. Further study is needed to enhance sustainability of effects beyond age 2.
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