Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus

Background Oxidative stress in children with type 1 DM (T1DM) may negatively affect the bone. Methods This study included 40 children with T1DM as the patient group and 40 healthy children of matched age and sex as the control group. Plasma alkaline phosphatase, procollagen type-1 amino-terminal propeptide (P1NP), and urinary deoxypyridinoline (DPD) were measured to assess bone turnover. Glutathione, superoxide dismutase (SOD), and malondialdehyde (MDA) were measured to assess oxidative stress. Results Patients with T1DM had a significantly lower P1NP level but a significantly higher urinary DPD level compared to the control group. Moreover, there were significantly lower glutathione and SOD levels with significantly higher MDA levels in patients with T1DM. We found a significant positive correlation between P1NP level and both glutathione and SOD levels but a significant negative correlation between P1NP and MDA in patients with T1DM. There was a significant negative correlation between DPD levels and both glutathione and SOD levels and a significant positive correlation between DPD and MDA. Moreover, glutathione was a significant predictor for both P1NP and DPD levels, while MDA was a significant predictor for P1NP levels. Conclusions There is an association between oxidative stress and bone turnover markers in children with T1DM. Impact Oxidative stress can negatively affect bone but the exact relationship between oxidative stress and bone turnover in T1DM has not been previously studied in pediatrics. For the best of our knowledge, our study was the first to assess the relationship between oxidative stress and bone turnover in children with T1DM. We revealed that increased oxidative stress in children and adolescents with T1DM may be involved in the impairment of bone turnover process, so treatment strategies toward better glycemic control and decreasing oxidative stress may be beneficial in preventing and treating diabetic bone disease in these children.

Automated summary

The study revealed an association between oxidative stress and bone turnover markers in children with type 1 diabetes, suggesting that oxidative stress may negatively affect bone. This was the first study to explore the relationship between oxidative stress and bone turnover in pediatrics with type 1 diabetes, indicating the potential significance for preventing and treating diabetic bone disease in these children by implementing strategies to control blood sugar levels and reduce oxidative stress.