Article
Clinical Neurology
Philippe Magown, Werner J. Becker, Zelma H. T. Kiss
Summary: The study found that occipital nerve regional stimulation (ONS) significantly improved long-term pain symptoms, reduced the number of headache days, and improved patients' quality of life.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Can Sarica, Christian Iorio-Morin, David H. Aguirre-Padilla, Michelle Paff, Samuelle-Arianne Villeneuve, Artur Vetkas, Kazuaki Yamamoto, Nardin Samuel, Vanessa Milano, Aaron Loh, Brendan Santyr, Ajmal Zemmar, Andres M. Lozano, Mojgan Hodaie
Summary: This study systematically reviewed the literature on peripheral nerve field stimulation (PNFS) for trigeminal pain and found that PNFS can provide effective long-term pain control for patients with trigeminal pain.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Michael D. D. Staudt, Salim M. M. Hayek, Joshua M. M. Rosenow, Samer Narouze, Jeffrey E. E. Arle, Julie G. G. Pilitsis, Jason M. M. Schwalb, Steven M. M. Falowski, Jennifer A. A. Sweet
Summary: This study conducted a systematic review of the literature on occipital nerve stimulation for occipital neuralgia and updated the evidence-based guidelines. The results indicate that occipital nerve stimulation can be used as a treatment option for patients with medically refractory occipital neuralgia.
Review
Biochemistry & Molecular Biology
Steven Char, Max Y. Jin, Vinicius Tieppo Francio, Nasir Hussain, Eric J. Wang, Mahmoud Morsi, Vwaire Orhurhu, Larry J. Prokop, Adam Fink, Ryan S. D'Souza
Summary: This review synthesized data from prospective studies on the efficacy of peripheral nerve stimulation (PNS) for neuropathic pain. The results showed that there is limited and low-quality evidence supporting the effectiveness of PNS for peripheral neuropathic pain, with modest improvement in pain and neurological function. Only PNS for phantom limb pain had moderate level evidence.
Article
Multidisciplinary Sciences
Benjamin U. Hoffman, Yoshichika Baba, Stephen A. Lee, Chi-Kun Tong, Elisa E. Konofagou, Ellen A. Lumpkin
Summary: This study successfully modulated the activity of peripheral neurons using targeted ultrasound stimulation and electrophysiology in mouse ex vivo skin-saphenous nerve preparations. The findings showed that high-intensity, millisecond ultrasound pulses reliably evoked action potentials in peripheral neurons, and there was a discrete range of parameters capable of exciting different types of neurons. Additionally, ultrasound stimulation could be targeted to cutaneous receptive fields or peripheral nerves, expanding the therapeutic range of ultrasound-based peripheral neuromodulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Clayton Busch, Olivia Smith, Tristan Weaver, Jayesh Vallabh, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) is a widely used interventional pain treatment modality for chronic lower extremity pain. Despite the lack of large prospective evidence, PNS has shown potential for improving pain scores, functionality, and opioid consumption, making it a viable option for patients with chronic lower extremity pain.
Article
Clinical Neurology
Aurelie Leplus, Denys Fontaine, Anne Donnet, Jean Regis, Christian Lucas, Nadia Buisset, Serge Blond, Sylvie Raoul, Evelyne Guegan-Massardier, Stephane Derrey, Bechir Jarraya, Bich Dang-Vu, Frederic Bourdain, Dominique Valade, Caroline Roos, Christelle Creach, Stephan Chabardes, Pierric Giraud, Jimmy Voirin, Jocelyne Bloch, Sophie Colnat-Coulbois, Francois Caire, Philippe Rigoard, Laurie Tran, Coralie Cruzel, Michel Lanteri-Minet
Summary: This study evaluated the long-term efficacy of occipital nerve stimulation (ONS) in treating refractory chronic cluster headache (rCCH) and found that ONS can significantly reduce attack frequency, improve quality of life, and emotional impacts in patients. In responders, ONS led to a major reduction of functional and emotional headache-related impacts and a dramatic improvement of quality of life.
Article
Clinical Neurology
Ida Stisen Fogh-Andersen, Jens Christian Hedemann Sorensen, Rigmor Hojland Jensen, Anne Lene Knudsen, Kaare Meier
Summary: This study reports the results of occipital nerve stimulation in 15 patients with chronic cluster headache. The results showed that occipital nerve stimulation significantly reduced the frequency and intensity of headache attacks, leading to clinically important improvement in patients' headache condition.
Review
Biochemistry & Molecular Biology
Lady Christine Ong Sio, Brian Hom, Shuchita Garg, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) has been widely used for treating chronic pain, although its mechanism of action remains largely unknown. The gate control theory proposed by Melzack and Wall in the 1960s has been the mainstay for understanding its mechanism. This review article discusses the mechanism of action, safety, and effectiveness of PNS in treating chronic pain, as well as current PNS devices available in the market.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Roemer B. Brandt, Leopoldine A. Wilbrink, Ilse F. de Coo, Joost Haan, Wim M. Mulleners, Frank J. P. M. Huygen, Erik W. van Zwet, Michel D. Ferrari, Rolf Fronczek
Summary: ONS is a safe, well-tolerated and long-term effective treatment for medically intractable chronic cluster headache.
Article
Multidisciplinary Sciences
Zakir Mridha, Jan Willem de Gee, Yanchen Shi, Rayan Alkashgari, Justin Williams, Aaron Suminski, Matthew P. Ward, Wenhao Zhang, Matthew James McGinley
Summary: The study demonstrates that pupil dilation is a reliable and noninvasive biosensor for titratable VNS-evoked cortical neuromodulation by acetylcholine in mice.
NATURE COMMUNICATIONS
(2021)
Article
Anesthesiology
Meghan McCullough, Deborah Kenney, Catherine Curtin, Einar Ottestad
Summary: Treatment of saphenous neuralgia has always been challenging. Our case series demonstrates the potential of peripheral nerve stimulation as a treatment for saphenous neuralgia. Comparative effectiveness studies are needed to assess whether our results are clinically significant.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Review
Anesthesiology
Jijun Xu, Zhuo Sun, Jiang Wu, Maunak Rana, Joshua Garza, Alyssa C. Zhu, Krishnan Chakravarthy, Alaa Abd-Elsayed, Ellen Rosenquist, Hersimren Basi, Paul Christo, Jianguo Cheng
Summary: PNS may be effective in managing chronic headaches, postamputation pain, chronic pelvic pain, and chronic low back and lower extremity pain.
Review
Clinical Neurology
Wenyu Pan, Joanna Peng, Dalia Elmofty
Summary: Occipital neuralgia is a painful condition affecting the posterior aspect of the head, with various treatment options including non-pharmacological treatments, nerve blocks, injections, and surgical interventions. Further research with larger sample sizes and randomized control trials are needed to evaluate the effectiveness and safety of these treatments.
CURRENT PAIN AND HEADACHE REPORTS
(2021)
Article
Neurosciences
Javier Diaz-de-Teran, Javier A. Membrilla, Jose Paz-Solis, Inigo de Lorenzo, Javier Roa, Manuel Lara-Lara, Alfonso Gil-Martinez, Exuperio Diez-Tejedor
Summary: The study suggests that occipital nerve stimulation (ONS) could be an interesting option for selected drug-resistant chronic cluster headache (drCCH) patients in the long term, as it can significantly reduce the frequency and intensity of headache attacks, improve overall perceived improvement, and decrease oral medication intake with minimal adverse events.
Review
Surgery
Jennifer M. Joseph, Davide Gori, Catherine Curtin, Jennifer Hah, Vy Thuy Ho, Steven M. Asch, Tina Hernandez-Boussard
Summary: The study assessed the availability of quality measures for postoperative pain management and National Quality Forum-endorsed measures. It found a lack of published postoperative pain management quality measures, especially those endorsed by the National Quality Forum. More rigorous evidence and widely endorsed quality measures are needed to guide best practices for postoperative pain management.
Review
Anesthesiology
Daniel B. Larach, Jennifer M. Hah, Chad M. Brummett
Summary: This article summarizes current evidence on perioperative opioid prescription fulfillment and use, and discusses the role of personalized anesthesia care in mitigating opioid-related harms without compromising analgesia.
Article
Anesthesiology
Robert W. Hurley, Meredith C. B. Adams, Meredith Barad, Arun Bhaskar, Anuj Bhatia, Andrea Chadwick, Timothy R. Deer, Jennifer Hah, W. Michael Hooten, Narayan R. Kissoon, David Wonhee Lee, Zachary Mccormick, Jee Youn Moon, Samer Narouze, David A. Provenzano, Byron J. Schneider, Maarten Van Eerd, Jan Van Zundert, Mark S. Wallace, Sara M. Wilson, Zirong Zhao, Steven P. Cohen
Summary: This study developed guidelines for the treatment of chronic neck pain through collaboration with 18 stakeholder societies, addressing crucial questions such as patient selection criteria, the use of conservative treatment before injections, and indications for radiofrequency ablation. Achieving consensus on 17 out of 20 questions, the study emphasized the importance of proper patient selection and the potential benefits of cervical medial branch radiofrequency ablation.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Review
Clinical Neurology
Timothy R. Deer, Jay S. Grider, Jason E. Pope, Tim J. Lamer, Sayed E. Wahezi, Jonathan M. Hagedorn, Steven Falowski, Reda Tolba, Jay M. Shah, Natalie Strand, Alex Escobar, Mark Malinowski, Anjum Bux, Navdeep Jassal, Jennifer Hah, Jacqueline Weisbein, Nestor D. Tomycz, Jessica Jameson, Erika A. Petersen, Dawood Sayed
Summary: Lumbar spinal stenosis (LSS) is a common spinal disease of aging with a growing patient population. The use of minimally invasive treatments needs guidance to ensure patient safety and efficacy outcomes. This article provides guidance for the best practice of minimally invasive surgical treatment for symptomatic LSS.
JOURNAL OF PAIN RESEARCH
(2022)
Review
Medicine, General & Internal
Nitin K. Prabhakar, Andrea L. Chadwick, Chinwe Nwaneshiudu, Anuj Aggarwal, Vafi Salmasi, Theresa R. Lii, Jennifer M. Hah
Summary: Perioperative pain management in patients undergoing spine surgery is challenging due to the high incidence of pre-existing chronic pain conditions and chronic postsurgical pain. An interdisciplinary approach is necessary to consider patient-level risk factors, as well as pharmacologic and nonpharmacologic pain management techniques. Psychological factors and patient education should also be taken into account to develop personalized pain management plans. While various techniques have shown effectiveness in the immediate postoperative period, long-term follow-up is needed to assess their impact on persistent pain and opioid use. Precision medicine may help identify patients at greatest risk of developing persistent postoperative pain after spine surgery.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Anesthesiology
Maisa S. Ziadni, Dokyoung S. You, Ryan Keane, Brett Salazar, Sam Jaros, Jesmin Ram, Anuradha Roy, Natalie Tanner, Vafi Salmasi, Michael Gardner, Beth D. Darnall
Summary: This study tested a digital perioperative behavioral medicine intervention in orthopedic trauma surgery patients for feasibility and efficacy for reducing pain intensity, pain catastrophizing, and opioid cessation up to 3 months after surgery. The results showed that the intervention was effective in reducing pain intensity but had no significant effect on opioid cessation and pain catastrophizing.
ANESTHESIA AND ANALGESIA
(2022)
Article
Clinical Neurology
Hemant Kalia, Scott Pritzlaff, Alice H. Li, Einar Ottestad, Amitabh Gulati, James Makous, Krishnan Chakravarthy
Summary: Peripheral nerve stimulation with the Nalu(TM) Neurostimulation System has proven to be effective in treating chronic neuropathic pain and shows promise in various chronic pain conditions.
Article
Anesthesiology
Todd Maddox, Heidy Garcia, Kelsey Ffrench, Roselani Maddox, Laura Garcia, Parthasarathy Krishnamurthy, David Okhotin, Charisse Sparks, Liesl Oldstone, Brandon Birckhead, Josh Sackman, Ian Mackey, Robert Louis, Vafi Salmasi, Alexis Oyao, Beth Darnall
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Review
Neurosciences
Vafi Salmasi, Theresa R. Lii, Keith Humphreys, Vinay Reddy, Sean C. Mackey
Summary: The use of exclusion criteria in clinical trials may limit the generalizability of study results. There is a lack of research on the impact of exclusion criteria on chronic pain patients, highlighting the need for more comprehensive studies to better understand these implications.
Letter
Anesthesiology
Todd Maddox, Charisse Sparks, Liesl Oldstone, Roselani Maddox, Kelsey Ffrench, Heidy Garcia, Parthasarathy Krishnamurthy, David Okhotin, Laura M. Garcia, Brandon J. Birckhead, Josh Sackman, Ian Mackey, Robert Louis, Vafi Salmasi, Alexis Oyao, Beth D. Darnall
Article
Anesthesiology
Alice Huai-Yu Li, Anuj Bhatia, Amit Gulati, Einar Ottestad
Summary: The use of peripheral nerve stimulation (PNS) in interventional pain management (IPM) for refractory neuropathic pain (NP) has increased in recent years. However, there is a lack of high-quality evidence and guidelines on this topic. A survey was conducted to understand the perception of physicians with expertise in treating NP regarding IPM and the role of PNS. The survey results showed that the distal common peroneal, tibial, and sural nerves were most frequently targeted with PNS, and persistent postsurgical pain was the most common indication for PNS.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Alban Zammit, Jean Coquet, Jennifer Hah, Oualid el Hajouji, Steven M. Asch, Ian Carroll, Catherine M. Curtin, Tina Hernandez-Boussard
Summary: Surgical patients with diabetes are at increased risk for prolonged opioid use (POU) even after controlling for likely covariates. Therefore, a more tailored approach to postoperative pain management for diabetic patients is warranted.
Article
Clinical Neurology
Jennifer M. Hah, Julien D. Veron Vialard, Bradley Efron, Sean C. Mackey, Ian R. Carroll, Derek F. Amanatullah, Balasubramanian Narasimhan, Tina Hernandez-Boussard
Summary: This study aimed to analyze the impact of preoperative and postoperative risk factors on persistent postoperative pain and opioid use. The results showed a significant association between preoperative opioid use and delayed postoperative opioid cessation, while postoperative increases in depressive symptoms and pain catastrophizing were independently associated with delayed postoperative pain resolution. Therefore, risk stratification of patients before and after surgery can identify those at highest risk for these distinct outcomes, and interventions targeting these perioperative risk factors may prevent prolonged postoperative pain and opioid use.
Correction
Surgery
J. Hah, S. C. Mackey, P. Schmidt
Correction
Surgery
J. Hah, S. C. Mackey, P. Schmidt