Journal
ORGANIC LETTERS
Volume 22, Issue 21, Pages 8441-8445Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03062
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Funding
- F.W.O. [Fund for Scientific Research-Flanders (Belgium)]
- Research Fund of the University of Leuven (KU Leuven)
- RUDN University Program [5-100]
- Hercules Foundation [AKUL/09/0035]
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A concise and flexible procedure for the synthesis of highly functionalized N-heterocyclic 1,6-annulated 2-pyridones and 2,3-annulated 4-pyrimidinones has been elaborated through a gold-catalyzed tandem hydroamination/cycloisomerization cascade. This novel and highly efficient method allows the rapid construction of these diverse N-heterocyclic scaffolds starting from readily available building blocks, and shows a wide scope and good functional group tolerance. The total synthesis of (+/-)-secoantofine and (+/-)-septicine were realized employing this strategy.
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