Journal
ORGANIC LETTERS
Volume 22, Issue 17, Pages 6780-6783Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02294
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- Deutsche Forschungsgemeinschaft (DFG)
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The total synthesis of (+)-galbulin was achieved in 15% yield and 99% ee over eight steps from commercially available 4-veratraldehyde. The key steps include Meyer's asymmetric tandem addition to a chiral 2-oxazoline-substituted naphthalene, a Pd-catalyzed stereospecific decarboxylative gamma-arylation, and a formal anti-Markovnikov hydromethylation. In addition, five unnatural lignans were synthesized using the same synthetic strategy.
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