Article
Chemistry, Applied
Yaping Yi, Chanjuan Xi
Summary: The photo-catalyzed tandem reaction of benzyl o-halogenated aryl ether with CO2 was achieved, leading to the synthesis of spirocyclic carboxylic acids. The reaction proceeds under mild conditions and exhibits good functional group tolerance with high yields. Mechanism studies elucidate that the transformation proceeds through intramolecular radical addition and nucleophilic addition.
CHINESE JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Physical
Chaoyue Zhao, Jicheng Yi, Lihong Wang, Guanyu Lu, Hui Huang, Ha Kyung Kim, Han Yu, Chen Xie, Peng You, Guanghao Lu, Mingxia Qiu, He Yan, Shunpu Li, Guangye Zhang
Summary: The development of PSMAs has significantly improved the efficiency of all-polymer solar cells. By improving processing methods and solvent selection, the electron mobility can be effectively increased, resulting in higher efficiency compared to traditional approaches.
Article
Biophysics
Wei-Hong Yin, Chang-Hai Zhou, Xiao-Jie Ju, Yi Deng, Lu Zhang, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: This study introduces a novel dual-functional PEEK material with a composite coating on its porous surface, demonstrating excellent osseointegration and early effective antibacterial activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Organic
Hui Chen, Mo Yang, Guoqiang Wang, Liuzhou Gao, Zhigang Ni, Jingxiang Zou, Shuhua Li
Summary: A borane-catalyzed sequential addition of terminal alkynes to para-substituted phenols has been developed, yielding ortho-propargylic alkylated phenols with congested quaternary carbons. Control experiments and DFT calculations suggest a sequential phenol alkenylation/hydroalkynylation process. The extension of this strategy to the construction of triaryl-substituted quaternary carbons demonstrates the broad utility of this method.
Article
Chemistry, Physical
P. Nandha Kumar, V. Ponnilavan, Wonjoo Lee, Jonghun Yoon
Summary: This study investigates the structural and mechanical stability of calcium phosphate-ZnO composites during sequential heat treatments. The results show that the addition of Zn2+ affects the structure of calcium phosphate and delays its transformation. Zn2+ plays a crucial role in the microstructural features and density of the material, influencing its solidity and stability.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Organic
John-Paul R. Marrazzo, Allen Chao, Yajun Li, Fraser F. Fleming
Summary: A copper iodide-Pyox complex catalyzes the first conjugate addition of diverse sulfur, nitrogen, and carbon nucleophiles to isocyanoalkenes, generating metalated isocyanoalkanes for SNi displacements. This provides a rapid route to a series of functionalized, cyclic isocyanoalkanes, laying a foundation for catalytic reactions maintaining the isocyanide group.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yoshitake Nishiyama, Kei Akiyama, Yuki Sakata, Takamitsu Hosoya, Suguru Yoshida
Summary: A facile synthetic method for unsymmetric tetraarylpyrazines by sequential cross-couplings has been disclosed. This 5-step synthesis was achieved from 2-amino-3,5-dibromo-6-chloropyrazine through four-fold cross-coupling and diazotization. In addition, dibenzo-fused quinoxaline synthesis was also accomplished by further intramolecular coupling.
Article
Engineering, Chemical
Yu Han, Fangyu Han, Liang Tao, Jinyang Jiang, Wenxiang Xu
Summary: Understanding the effects of particle configurations on pore tortuosity and diffusivity of porous composites is crucial for the evaluation of durability in various applications. This study proposes two numerical strategies to accurately probe pore tortuosity and effective diffusivity, and validates their accuracy against theoretical data. The derived results provide insights into the relationship between particle configurations and transport properties of porous composites, guiding the design and optimization of composites.
News Item
Chemistry, Multidisciplinary
Abraham Ustoyev, Mitchell P. Croatt
Summary: Dipolar cycloadditions are effective for forming heterocyclic systems from simple starting materials. However, the utilization of arenes as dipolarophiles remains underexplored. In this study, the intramolecular dipolar cycloaddition of aromatic rings was successfully achieved using in situ generated diazoalkenes, resulting in the formation of bicyclic or tricyclic heterocycles.
Article
Chemistry, Multidisciplinary
Peter Ribar, Leos Valenta, Tomas Solomek, Michal Juricek
Summary: The nucleophilic addition of carbon-centered nucleophiles to nanographene ketones is a valuable late-stage method for functionalizing zigzag nanographenes, with potential for synthesizing and exploring previously unknown functionalized nanographenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Microbiology
Jize Xu, Xiaodong Yu, Nakarin Suwannarach, Yi Jiang, Wei Zhao, Yu Li
Summary: Four new species, Calocybe coacta, C. fulvipes, C. vinacea and Clitolyophyllum umbilicatum, have been described in northern China with unique morphological characteristics that distinguish them from closely related species. Detailed comparisons of macro- and micromorphological features, phylogenetic analyses, color images, illustrations, and a phylogenetic tree have been provided to showcase the distinctiveness of these new species. Additionally, a key to Calocybe species reported from China has been included.
Article
Biodiversity Conservation
Jorge Fontes, Joeva Dachelet, Ricardo Serrao Santos, Bruno C. L. Macena, Pedro Afonso
Summary: In this article, new and unique records of marine fish with pigmentation abnormalities are presented, including a case of an albino-melanistic fish, a leucistic great hammerhead shark (Sphyrna mokarran), leucistic Almaco jacks (Seriola rivoliana), and a melanistic giant manta (Mobula birostris) in the north Atlantic. The authors speculate that these pigmentary abnormalities may be linked to significant population declines and isolation of remote populations.
ECOLOGICAL INDICATORS
(2023)
Article
Engineering, Environmental
Bo Liu, Chao Zhou, Zhongtian Zhang, James D. Roland, Bruce P. Lee
Summary: The study synthesized a series of halogenated dopamine methacrylamide compounds with broad-spectrum antimicrobial activity for designing bioadhesives and coatings. Experimental and simulation studies demonstrated their efficient bactericidal function, especially against multidrug-resistant bacteria, providing new potential for designing multifunctional bioadhesives and coatings.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Luhui Wang, Zihao Wei, Ling Lv, Changhu Xue
Summary: This study developed multilayer structural nanoparticles (MSNPs) for the coencapsulation of resveratrol and vitamin D3. The co-encapsulated MSNPs demonstrated high stability and efficient drug delivery, releasing the drugs sequentially in simulated gastrointestinal fluids. In vivo experiments showed that these nanoparticles alleviated clinical symptoms of colitis and suppressed inflammation and oxidative damage in mice. This research highlights the potential of MSNPs as carriers for the synergistic prevention and treatment of ulcerative colitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Editorial Material
Public, Environmental & Occupational Health
Nabarun Dasgupta, Mary C. Figgatt
Summary: This article presents a novel analysis of time trends in fentanyl concentrations in the unregulated drug supply in British Columbia and emphasizes the importance of large-scale drug-checking programs in mitigating health risks for drug users. The authors propose two guiding principles for these programs: timely delivery of results to drug users and the need for innovation in laboratory analysis to gain a better understanding of health concerns.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Chemistry, Medicinal
David H. Drewry, Joel K. Annor-Gyamfi, Carrow Wells, Julie E. Pickett, Verena Dederer, Franziska Preuss, Sebastian Mathea, Alison D. Axtman
Summary: The pyrimidine core has been widely used in constructing kinase inhibitors, and the strategy of utilizing nonexemplified aminopyrimidines with side chains from annotated inhibitors has provided useful inhibitors for understudied kinases. By mixing and matching side chains from parent compounds and modifying the 5-position of the pyrimidine core, improved kinome-wide selectivity was achieved. Important lead compounds for understudied kinases such as DRAK1, BMP2K, and MARK3/4 were also identified through this approach.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Amelia U. Schirmer, Lucy M. Driver, Megan T. Zhao, Carrow Wells, Julie E. Pickett, Sean N. O'Bryne, Benjamin J. Eduful, Xuan Yang, Lauren Howard, Sungyong You, Gayathri R. Devi, John DiGiovanni, Stephen J. Freedland, Jen-Tsan Chi, David H. Drewry, Everardo Macias
Summary: STK3 plays a pro-tumorigenic role in prostate cancer and is associated with tumor progression and patient survival. Inhibition of STK3 can slow tumor growth and invasion, and has therapeutic potential.
Article
Multidisciplinary Sciences
Timothy J. Fazekas, Jill W. Alty, Eliza K. Neidhart, Austin S. Miller, Frank A. Leibfarth, Erik J. Alexanian
Summary: This study reports an approach to achieve diverse functionality on hydrocarbons by utilizing radical chain transfer. By using an easily prepared reagent, a range of functionalizations on small molecules and polyolefins can be achieved. This method has also been applied in the processing of plastic waste and enables the introduction of ionic functionality on polyolefins, transforming them into elastomers with high-value properties.
Article
Chemistry, Medicinal
Christopher R. M. Asquith, Louisa Temme, Michael P. East, Tuomo Laitinen, Julie Pickett, Frank E. Kwarcinski, Parvathi Sinha, Carrow Wells, Gary L. Johnson, Reena Zutshi, David H. Drewry
Summary: Compound 16 was identified as a potent inhibitor of Protein Kinase Novel 3 (PKN3) with micromolar activity in cells. It has the potential to serve as a tool compound for studying the cell biology of PKN3 and its role in pancreatic and prostate cancer and T-cell acute lymphoblastic leukemia.
Article
Chemistry, Organic
Joshua G. Welfare, Michael J. Mortelliti, Caylie A. McGlade, Timothy W. Hartman, Jillian L. Dempsey, David S. Lawrence
Summary: Cobalamin has shown potential as a light-sensitive drug delivery platform. Water-soluble cobalamin conjugates have high photolysis efficiency, while hydrophobic cobalamin conjugates show higher photolysis efficiency in organic solvents.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Hannah M. Hynds, Holli E. Lemons, Jasmine D. Willis, MarKayla J. Bell, Sydney E. Bottcher, Mei Lin N. Dye, Emily T. Echols, Edward L. Garner, Lauren E. Hutchinson, Caleb M. Phillips, Claudia P. Stephens, Thomas M. Gilbert, Dale J. Wilger
Summary: A new method for synthesizing indenones using a nickel-catalyzed annulation reaction is reported. The reaction shows high yields and regioselectivities when using aliphatic- and silyl-substituted alkynes, which have been challenging and underutilized substrate classes. Mechanistic observations aided in the development of this reaction, and the researchers anticipate that these methods will be quickly adopted due to their synthetic ease and versatility.
Article
Biochemistry & Molecular Biology
Julia A. Brom, Gary J. Pielak
Summary: This study investigates the water adsorption ability of desiccation-tolerance proteins using thermogravimetric analysis, and finds that modulated water retention is not the key factor for dehydration protection.
Article
Multidisciplinary Sciences
Sung Yun Son, Giwon Lee, Hongyu Wang, Stephanie Samson, Qingshan Wei, Yong Zhu, Wei You
Summary: A novel random polythiophene (RP-T50) material was designed, which showed significantly improved charge mobility and stability upon thermal annealing, while generating wrinkles in the polymer film to enhance its stretchability. The RP-T50-based stretchable sensor exhibited outstanding performance in detecting various environmental parameters under different stretching conditions.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Tuomo Laitinen, Theres Meili, Maria Koyioni, Panayiotis A. Koutentis, Antti Poso, Regina Hofmann-Lehmann, Christopher R. M. Asquith
Summary: In this study, a series of potent anti-viral compounds derived from 4,5-dichloro-1,2,3-dithiazolium chloride were synthesized through a concise approach. Screening against FIV infected cells led to the discovery of sub-micromolar anti-viral compounds with reduced toxicity. Mechanistic understanding was gained through advanced QM-MM modeling.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Clinical Neurology
Anne E. Sanders, E. Diane Weatherspoon, Brandie M. Ehrmann, Paul S. Soma, Saame R. Shaikh, John S. Preisser, Richard Ohrbach, Roger B. Fillingim, Gary D. Slade
Summary: Preclinical studies have shown that long-chain polyunsaturated fatty acids (PUFAs) have opposing effects on inflammation and nociception. Omega-6 (n-6) PUFAs amplify both processes, while omega-3 (n-3) PUFAs inhibit them. This study found that a higher ratio of n-6/n-3 long-chain PUFAs in circulating erythrocytes was associated with a greater likelihood of temporomandibular disorder (TMD) and low back pain in a sample of U.S. adults.
Article
Multidisciplinary Sciences
Pedro de Jesus Cruz, William R. Cassels, Chun-Hsing Chen, Jeffrey S. Johnson
Summary: This study reports the discovery and development of a new synthetic method that allows simultaneous control over multiple stereogenic centers for efficient preparation of pharmaceutical compounds. By merging asymmetric Michael addition and crystallization-induced diastereomer transformation, useful compounds with three contiguous stereogenic centers have been successfully synthesized.
Article
Chemistry, Multidisciplinary
Joseph P. Mancinelli, Wang-Yeuk Kong, Wentao Guo, Dean J. Tantillo, Sidney M. Wilkerson-Hill
Summary: In this study, a method for synthesizing tert-alkyl cyclopropanes through C-F bond functionalization of gem-difluorocyclopropenes using tris(pentafluorophenyl)borane catalysis is disclosed. The reaction proceeds through the intermediacy of a fluorocyclopropenium ion, which was confirmed by the isolation of [Ph-2(C6D5)C-3](+)[(C6F5)(3)BF](-). It was found that silylketeneacetal nucleophiles were optimal reaction partners, yielding fully substituted cyclopropenes functionalized with two α-tert-alkyl centers (63-93% yield).
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Joseph P. Mancinelli, Shubin Liu, Sidney M. Wilkerson-Hill
Summary: In this study, we quantified the rates of alkylation for several substituted phosphines, and found that the introduction of a single pinacol boronic ester group in the ortho-position on triphenylphosphine significantly increased the rate of substitution with benzyl bromide. This rate acceleration is proposed to be due to an O to P electrostatic interaction that stabilizes the transition state, as supported by X-ray crystallographic data and quantum chemical calculations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
