Journal
ORGANIC LETTERS
Volume 22, Issue 20, Pages 7971-7975Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02815
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Funding
- National Institutes of Health (NIBIB) [1R01EB029451]
- UNC Department of Radiology
- Biomedical Research Imaging Center
- UNC Lineberger Comprehensive Cancer Center
- UNC LCCC pilot grant
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Herein, we describe an organic photoredox system for direct arene C-H radiofluorination, using a peroxide oxidizing agent and LEDs as the light source. In conjunction with an optimized photocatalyst and a microtubing reactor, this system is applicable to a range of electron-rich aromatics and heteroaromatics. We also demonstrate the feasibility of C-H radiofluorination without an azeotropic drying step, which greatly simplifies the workflow of the labeling process.
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